HUMAN:FYN

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FYN
Protein Name(s)	Tyrosine-protein kinase Fyn Proto-oncogene Syn Proto-oncogene c-Fyn Src-like kinase SLK p59-Fyn
External Links
UniProt	P06241
EMBL	M14676 M14333 S74774 AB451293 AB451426 Z97989 Z97989 CH471051 CH471051 CH471051 CH471051 CH471051 BC032496
CCDS	CCDS5094.1 CCDS5095.1 CCDS5096.1
PIR	A24314
RefSeq	NP_002028.1 NP_694592.1 NP_694593.1 XP_005266947.1 XP_005266949.1
UniGene	Hs.390567 Hs.664520
PDB	1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK
PDBsum	1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK
ProteinModelPortal	P06241
SMR	P06241
BioGrid	108810
DIP	DIP-33876N
IntAct	P06241
MINT	MINT-93594
STRING	9606.ENSP00000346671
BindingDB	P06241
ChEMBL	CHEMBL1841
DrugBank	DB01254
GuidetoPHARMACOLOGY	2026
PhosphoSite	P06241
BioMuta	FYN
DMDM	125370
MaxQB	P06241
PaxDb	P06241
PRIDE	P06241
DNASU	2534
Ensembl	ENST00000229471 ENST00000354650 ENST00000368667 ENST00000368678 ENST00000368682 ENST00000538466
GeneID	2534
KEGG	hsa:2534
UCSC	uc003pvh.3 uc003pvi.3 uc003pvj.3
CTD	2534
GeneCards	GC06M111981
HGNC	HGNC:4037
HPA	CAB005034 CAB018387 HPA023887
MIM	137025
neXtProt	NX_P06241
PharmGKB	PA28454
eggNOG	COG0515
GeneTree	ENSGT00760000118938
HOVERGEN	HBG008761
InParanoid	P06241
KO	K05703
OMA	SHNSGYR
OrthoDB	EOG7GTT2V
PhylomeDB	P06241
TreeFam	TF351634
BRENDA	2.7.10.2
Reactome	REACT_11068 REACT_111040 REACT_111225 REACT_115755 REACT_118700 REACT_12051 REACT_1230 REACT_12519 REACT_147727 REACT_147814 REACT_160274 REACT_163769 REACT_1695 REACT_18334 REACT_19183 REACT_19199 REACT_19236 REACT_19238 REACT_19279 REACT_19358 REACT_19405 REACT_22351 REACT_22384 REACT_23787 REACT_23832 REACT_263952 REACT_264047 REACT_264068 REACT_264198 REACT_264464 REACT_264548 REACT_355442 REACT_355503 REACT_75829
SignaLink	P06241
ChiTaRS	FYN
EvolutionaryTrace	P06241
GeneWiki	FYN
GenomeRNAi	2534
NextBio	9997
PMAP-CutDB	P06241
PRO	PR:P06241
Proteomes	UP000005640
Bgee	P06241
CleanEx	HS_FYN
ExpressionAtlas	P06241
Genevisible	P06241
GO	GO:0005884 GO:0005829 GO:0005768 GO:0031234 GO:0005739 GO:0005634 GO:0005886 GO:0014069 GO:0005524 GO:0046875 GO:0001948 GO:0070851 GO:0046872 GO:0004715 GO:0004713 GO:0050798 GO:0007411 GO:0007596 GO:0006816 GO:0030154 GO:0016477 GO:0071375 GO:0036120 GO:0071560 GO:0048813 GO:0050966 GO:0048013 GO:0007173 GO:0038095 GO:0038096 GO:0007631 GO:0008543 GO:0030900 GO:0045087 GO:0035556 GO:0007612 GO:0050900 GO:2001240 GO:0010629 GO:0043524 GO:0042177 GO:0031397 GO:0001764 GO:0048011 GO:0038083 GO:0018108 GO:0048015 GO:0030168 GO:0043123 GO:0010976 GO:0014068 GO:1900182 GO:0042523 GO:0006468 GO:0042981 GO:0042127 GO:0008360 GO:0050690 GO:0042493 GO:0045471 GO:0002223 GO:0042110 GO:0031295 GO:0050852 GO:0007169 GO:0048010 GO:0016032
Gene3D	3.30.505.10
InterPro	IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635
Pfam	PF07714 PF00017 PF00018
PRINTS	PR00401 PR00452 PR00109
SMART	SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0097038	perinuclear endoplasmic reticulum	PMID:27525436^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	C	part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:27525436^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	C	part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:27525436^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	C	part_of:(CL:0000746) part_of:(GO:0048471)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:27525436^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	C	part_of:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:1903202	negative regulation of oxidative stress-induced cell death	PMID:27525436^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	P	has_regulation_target:(UniProtKB:Q9NPH5) regulates_o_occurs_in:(CL:0000746) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	PMID:27525436^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:27525436^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	P	has_input:(UniProtKB:Q9NPH5) occurs_in:(CL:0000746) negatively_regulates:(GO:1903409)	Seeded From UniProt	complete
involved_in	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	PMID:27525436^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	P	has_regulation_target:(UniProtKB:Q9NPH5) regulates_o_occurs_in:(CL:0000746) occurs_in:(CL:0000746) regulates_o_occurs_in:(GO:0005739)\|has_regulation_target(UniProtKB:Q9NPH5) regulates_o_occurs_in:(CL:0000746) occurs_in:(CL:0000746) regulates_o_occurs_in:(GO:0005783)\|has_regulation_target(UniProtKB:Q9NPH5) regulates_o_occurs_in:(CL:0000746) occurs_in:(CL:0000746) regulates_o_occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0000304	response to singlet oxygen	PMID:27525436^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	P	occurs_in:(CL:0000746) negatively_regulates:(GO:0036473)	Seeded From UniProt	complete
involved_in	GO:0003015	heart process	PMID:27525436^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9NPH5	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:27525436^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9JHI8	F	occurs_in:(CL:0000746) occurs_in:(GO:0048471)\|occurs_in:(CL:0000746) occurs_in:(GO:0005739)\|occurs_in:(CL:0000746) occurs_in:(GO:0005634)\|occurs_in:(CL:0000746) occurs_in:(GO:0097038)\|occurs_in:(CL:0000746) part_of:(GO:0006979)	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:27520374^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000540) has_input:(UniProtKB:P10636) part_of:(GO:1904646)	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:27520374^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:28386764^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:28386764^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0097386	glial cell projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	C	part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	C	part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	C	part_of:(CL:0000128)	Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	F	occurs_in:(CL:0000128) occurs_at:(GO:0045121)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10637	F	occurs_in:(CL:0000128) occurs_at:(GO:0045121) positively_regulates:(GO:0106091)	Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	P		Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	PMID:17526495^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	P	part_of:(GO:1905232) part_of:(GO:1905430) regulates_o_occurs_in:(GO:0009986)	Seeded From UniProt	complete
involved_in	GO:1905430	cellular response to glycine	PMID:17526495^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	P	happens_during:(GO:1905232)	Seeded From UniProt	complete
involved_in	GO:1905232	cellular response to L-glutamate	PMID:17526495^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	P	happens_during:(GO:1905430)	Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	PMID:9351809^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03406	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	C	part_of:(GO:0030425) part_of:(CL:1001571)	Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:23386614^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:16979591^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q9NQC3)	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:16979591^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9NQC3)	Seeded From UniProt	complete
colocalizes_with	GO:0045121	membrane raft	PMID:12150984^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084) part_of:(GO:0005886)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12150984^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
involved_in	GO:1900449	regulation of glutamate receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:17526495^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	F	has_input:(UniProtKB:Q13224) positively_regulates:(GO:0004197) occurs_in:(GO:0009986)\|has_input(UniProtKB:Q13224) occurs_in:(GO:0005622)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15611048^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:15611048^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	PMID:16479011^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09619	F		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:7722293^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	PMID:10498895^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O09127	F		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:7822789^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:7822789^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:7822789^[13]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62844	C		Seeded From UniProt	complete
involved_in	GO:1905664	regulation of calcium ion import across plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609) causally_upstream_of:(GO:1901216) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:1902951	negative regulation of dendritic spine maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609) part_of:(GO:1904645) has_regulation_target:(UniProtKB:Q13224)	Seeded From UniProt	complete
involved_in	GO:0090314	positive regulation of protein targeting to membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609) part_of:(GO:1904645) has_regulation_target:(UniProtKB:Q13224) regulates:(GO:0098703)	Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521487 UniProtKB:P06241	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:Q9H3Y6 WB:WBGene00005077	P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P08631	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 RGD:621423	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P07948	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262733 PANTHER:PTN002521528 RGD:2641 RGD:620795 RGD:621017 UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95527 PANTHER:PTN002521528 UniProtKB:P09769 UniProtKB:P51451 UniProtKB:Q13882 WB:WBGene00005077	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:9799234^[15]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:27692963^[16]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:18697750^[17]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:1381360^[18]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:12923167^[19]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:11448999^[20]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:27001024^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06241	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:14993658^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06241	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1905664	regulation of calcium ion import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:1902951	negative regulation of dendritic spine maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:1900449	regulation of glutamate receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	C		Seeded From UniProt	complete
part_of	GO:0097386	glial cell projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	C		Seeded From UniProt	complete
involved_in	GO:0090314	positive regulation of protein targeting to membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	C		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0050798	activated T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	F		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	C		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	F		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0036120	cellular response to platelet-derived growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	C		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	C		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	F		Seeded From UniProt	complete
involved_in	GO:0003015	heart process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39688 ensembl:ENSMUSP00000097547	F		Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:1905430	cellular response to glycine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:1905232	cellular response to L-glutamate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:1903202	negative regulation of oxidative stress-induced cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
enables	GO:0042610	CD8 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0042609	CD4 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0042608	T cell receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
involved_in	GO:0000304	response to singlet oxygen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:28386764^[3] PMID:17526495^[4] PMID:1361685^[23] Reactome:R-HSA-5218812 Reactome:R-HSA-5218806 Reactome:R-HSA-374701 Reactome:R-HSA-1433506	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	has_input:(UniProtKB:P10636) regulates:(GO:0098930)	Seeded From UniProt	complete
involved_in	GO:1905477	positive regulation of protein localization to membrane	PMID:28386764^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:P10636) causally_upstream_of:(GO:0031175)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:28386764^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:25707991^[24] PMID:3526330^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:Q14289)	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:25707991^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:25707991^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	part_of:(GO:0018108)	Seeded From UniProt	complete
involved_in	GO:0097062	dendritic spine maintenance	PMID:25707991^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:1361685^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	PMID:8264796^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:1361685^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-388831 Reactome:R-HSA-388829 Reactome:R-HSA-388814 Reactome:R-HSA-373747 Reactome:R-HSA-373734 Reactome:R-HSA-373724 Reactome:R-HSA-2424487 Reactome:R-HSA-2424486 Reactome:R-HSA-2424484 Reactome:R-HSA-2424482 Reactome:R-HSA-2424480 Reactome:R-HSA-2400009 Reactome:R-HSA-2396594 Reactome:R-HSA-2395801 Reactome:R-HSA-2395412 Reactome:R-HSA-2316434 Reactome:R-HSA-210291 Reactome:R-HSA-210289 Reactome:R-HSA-205319 Reactome:R-HSA-205244 Reactome:R-HSA-205238 Reactome:R-HSA-205234 Reactome:R-HSA-2029459 Reactome:R-HSA-200908 Reactome:R-HSA-1562641 Reactome:R-HSA-1472121 Reactome:R-HSA-1470012 Reactome:R-HSA-1470010 Reactome:R-HSA-1470009 Reactome:R-HSA-1433542 Reactome:R-HSA-1433514 Reactome:R-HSA-1433506 Reactome:R-HSA-1433488 Reactome:R-HSA-1433456 Reactome:R-HSA-1433454 Reactome:R-HSA-1433451 Reactome:R-HSA-1433428 Reactome:R-HSA-1433418 Reactome:R-HSA-139842 Reactome:R-HSA-114600 Reactome:R-HSA-114577 Reactome:R-HSA-912627 Reactome:R-HSA-8981534 Reactome:R-HSA-8855237 Reactome:R-HSA-879917 Reactome:R-HSA-5672965 Reactome:R-HSA-5624486 Reactome:R-HSA-5621355 Reactome:R-HSA-532603 Reactome:R-HSA-5218854 Reactome:R-HSA-5218847 Reactome:R-HSA-5218832 Reactome:R-HSA-5218824 Reactome:R-HSA-5218814 Reactome:R-HSA-5218812 Reactome:R-HSA-5218806 Reactome:R-HSA-5218804 Reactome:R-HSA-453200 Reactome:R-HSA-453183 Reactome:R-HSA-437118 Reactome:R-HSA-432295 Reactome:R-HSA-4093336 Reactome:R-HSA-4093327 Reactome:R-HSA-399952 Reactome:R-HSA-399951 Reactome:R-HSA-399947 Reactome:R-HSA-399944 Reactome:R-HSA-399939 Reactome:R-HSA-399933 Reactome:R-HSA-399930 Reactome:R-HSA-3928651 Reactome:R-HSA-3928645 Reactome:R-HSA-3928642 Reactome:R-HSA-3928641 Reactome:R-HSA-3928640 Reactome:R-HSA-3928639 Reactome:R-HSA-3928633 Reactome:R-HSA-3928631 Reactome:R-HSA-3928628 Reactome:R-HSA-3928627 Reactome:R-HSA-3928625 Reactome:R-HSA-3928615 Reactome:R-HSA-3928614 Reactome:R-HSA-3928607 Reactome:R-HSA-3928604 Reactome:R-HSA-392054 Reactome:R-HSA-392053 Reactome:R-HSA-392051 Reactome:R-HSA-389381 Reactome:R-HSA-389354 Reactome:R-HSA-389352 Reactome:R-HSA-389350 Reactome:R-HSA-389348 Reactome:R-HSA-389158 Reactome:R-HSA-388833 Reactome:R-HSA-388832	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903997	positive regulation of non-membrane spanning protein tyrosine kinase activity	Reactome:R-HSA-9032500	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	Reactome:R-HSA-202733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050690	regulation of defense response to virus by virus	Reactome:R-HSA-164944	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	Reactome:R-HSA-2682334	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	Reactome:R-HSA-389356 Reactome:R-HSA-388841	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-512988	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-109582	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-9032798 Reactome:R-HSA-418874 Reactome:R-HSA-418868 Reactome:R-HSA-418858 Reactome:R-HSA-418856 Reactome:R-HSA-418850 Reactome:R-HSA-374701 Reactome:R-HSA-373716	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Matsushima, S et al. (2016) Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J. Clin. Invest. 126 3403-16 PubMed GONUTS page
↑ ^2.0 ^2.1 Liu, W et al. (2016) miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease. Biochem. Biophys. Res. Commun. 478 852-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Wu, HY et al. (2007) Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. J. Biol. Chem. 282 20075-87 PubMed GONUTS page
↑ Arold, S et al. (1997) The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure 5 1361-72 PubMed GONUTS page
↑ Rushworth, JV et al. (2013) Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J. Biol. Chem. 288 8935-51 PubMed GONUTS page
↑ ^7.0 ^7.1 Yokoyama, K et al. (2006) Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases. Biochem. Biophys. Res. Commun. 349 1401-5 PubMed GONUTS page
↑ ^8.0 ^8.1 Morford, LA et al. (2002) Calpain II colocalizes with detergent-insoluble rafts on human and Jurkat T-cells. Biochem. Biophys. Res. Commun. 295 540-6 PubMed GONUTS page
↑ ^9.0 ^9.1 Puertollano, R (2005) Interactions of TOM1L1 with the multivesicular body sorting machinery. J. Biol. Chem. 280 9258-64 PubMed GONUTS page
↑ Franco, M et al. (2006) The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Mol. Cell. Biol. 26 1932-47 PubMed GONUTS page
↑ Lancki, DW et al. (1995) Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1. J. Immunol. 154 4363-70 PubMed GONUTS page
↑ Choi, S & Park, S (1999) Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. Oncogene 18 5413-22 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Rigley, K et al. (1995) Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells. J. Immunol. 154 1136-45 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Timokhina, I et al. (1998) Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation. EMBO J. 17 6250-62 PubMed GONUTS page
↑ Huculeci, R et al. (2016) Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure 24 1947-1959 PubMed GONUTS page
↑ Sun, J et al. (2008) Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J. Biol. Chem. 283 27444-51 PubMed GONUTS page
↑ Alai, M et al. (1992) Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. J. Biol. Chem. 267 18021-5 PubMed GONUTS page
↑ Araki, T et al. (2003) Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors. J. Biol. Chem. 278 41677-84 PubMed GONUTS page
↑ Marignani, PA & Carpenter, CL (2001) Vav2 is required for cell spreading. J. Cell Biol. 154 177-86 PubMed GONUTS page
↑ Weir, ME et al. (2016) Novel autophosphorylation sites of Src family kinases regulate kinase activity and SH2 domain-binding capacity. FEBS Lett. 590 1042-52 PubMed GONUTS page
↑ Macdonald, A et al. (2004) The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity. J. Gen. Virol. 85 721-9 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Grant, SG et al. (1992) Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258 1903-10 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Kaufman, AC et al. (2015) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann. Neurol. 77 953-71 PubMed GONUTS page
↑ Semba, K et al. (1986) yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc. Natl. Acad. Sci. U.S.A. 83 5459-63 PubMed GONUTS page
↑ Yagi, T et al. () A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice. Nature 366 742-5 PubMed GONUTS page

[PMID:27525436-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Matsushima, S et al. (2016) Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J. Clin. Invest. 126 3403-16 PubMed GONUTS page

[PMID:27520374-2] 2.0 ^2.1 Liu, W et al. (2016) miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease. Biochem. Biophys. Res. Commun. 478 852-7 PubMed GONUTS page

[PMID:28386764-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:17526495-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Wu, HY et al. (2007) Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. J. Biol. Chem. 282 20075-87 PubMed GONUTS page

[PMID:9351809-5] Arold, S et al. (1997) The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure 5 1361-72 PubMed GONUTS page

[PMID:23386614-6] Rushworth, JV et al. (2013) Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J. Biol. Chem. 288 8935-51 PubMed GONUTS page

[PMID:16979591-7] 7.0 ^7.1 Yokoyama, K et al. (2006) Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases. Biochem. Biophys. Res. Commun. 349 1401-5 PubMed GONUTS page

[PMID:12150984-8] 8.0 ^8.1 Morford, LA et al. (2002) Calpain II colocalizes with detergent-insoluble rafts on human and Jurkat T-cells. Biochem. Biophys. Res. Commun. 295 540-6 PubMed GONUTS page

[PMID:15611048-9] 9.0 ^9.1 Puertollano, R (2005) Interactions of TOM1L1 with the multivesicular body sorting machinery. J. Biol. Chem. 280 9258-64 PubMed GONUTS page

[PMID:16479011-10] Franco, M et al. (2006) The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Mol. Cell. Biol. 26 1932-47 PubMed GONUTS page

[PMID:7722293-11] Lancki, DW et al. (1995) Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1. J. Immunol. 154 4363-70 PubMed GONUTS page

[PMID:10498895-12] Choi, S & Park, S (1999) Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. Oncogene 18 5413-22 PubMed GONUTS page

[PMID:7822789-13] 13.0 ^13.1 ^13.2 Rigley, K et al. (1995) Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells. J. Immunol. 154 1136-45 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9799234-15] Timokhina, I et al. (1998) Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation. EMBO J. 17 6250-62 PubMed GONUTS page

[PMID:27692963-16] Huculeci, R et al. (2016) Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure 24 1947-1959 PubMed GONUTS page

[PMID:18697750-17] Sun, J et al. (2008) Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J. Biol. Chem. 283 27444-51 PubMed GONUTS page

[PMID:1381360-18] Alai, M et al. (1992) Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. J. Biol. Chem. 267 18021-5 PubMed GONUTS page

[PMID:12923167-19] Araki, T et al. (2003) Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors. J. Biol. Chem. 278 41677-84 PubMed GONUTS page

[PMID:11448999-20] Marignani, PA & Carpenter, CL (2001) Vav2 is required for cell spreading. J. Cell Biol. 154 177-86 PubMed GONUTS page

[PMID:27001024-21] Weir, ME et al. (2016) Novel autophosphorylation sites of Src family kinases regulate kinase activity and SH2 domain-binding capacity. FEBS Lett. 590 1042-52 PubMed GONUTS page

[PMID:14993658-22] Macdonald, A et al. (2004) The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity. J. Gen. Virol. 85 721-9 PubMed GONUTS page

[PMID:1361685-23] 23.0 ^23.1 ^23.2 Grant, SG et al. (1992) Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258 1903-10 PubMed GONUTS page

[PMID:25707991-24] 24.0 ^24.1 ^24.2 ^24.3 Kaufman, AC et al. (2015) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann. Neurol. 77 953-71 PubMed GONUTS page

[PMID:3526330-25] Semba, K et al. (1986) yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc. Natl. Acad. Sci. U.S.A. 83 5459-63 PubMed GONUTS page

[PMID:8264796-26] Yagi, T et al. () A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice. Nature 366 742-5 PubMed GONUTS page

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