HUMAN:FTO

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FTO (synonyms: KIAA1752)
Protein Name(s)	Alpha-ketoglutarate-dependent dioxygenase FTO Fat mass and obesity-associated protein
External Links
UniProt	Q9C0B1
EMBL	AB051539 AC007347 AC007496 AC007909 BC003583 BC030798 BC132892 BC137091
CCDS	CCDS32448.1
RefSeq	NP_001073901.1
UniGene	Hs.528833
PDB	3LFM 4CXW 4CXX 4CXY 4IDZ 4IE0 4IE4 4IE5 4IE6 4IE7
PDBsum	3LFM 4CXW 4CXX 4CXY 4IDZ 4IE0 4IE4 4IE5 4IE6 4IE7
ProteinModelPortal	Q9C0B1
SMR	Q9C0B1
BioGrid	122520
IntAct	Q9C0B1
STRING	9606.ENSP00000418823
BindingDB	Q9C0B1
ChEMBL	CHEMBL2331065
PhosphoSite	Q9C0B1
DMDM	148841515
MaxQB	Q9C0B1
PaxDb	Q9C0B1
PRIDE	Q9C0B1
DNASU	79068
Ensembl	ENST00000431610 ENST00000460382 ENST00000463855 ENST00000471389
GeneID	79068
KEGG	hsa:79068
UCSC	uc002ehr.3 uc010cbz.3
CTD	79068
GeneCards	GC16P053737
H-InvDB	HIX0013037 HIX0134382 HIX0204005
HGNC	HGNC:24678
HPA	CAB017123
MIM	610966 612938
neXtProt	NX_Q9C0B1
Orphanet	210144
PharmGKB	PA152208656
eggNOG	NOG45792
GeneTree	ENSGT00390000017730
HOGENOM	HOG000273870
HOVERGEN	HBG101847
InParanoid	Q9C0B1
OMA	AVYNYSC
OrthoDB	EOG7CK36T
PhylomeDB	Q9C0B1
TreeFam	TF333296
ChiTaRS	FTO
GeneWiki	FTO_gene
GenomeRNAi	79068
NextBio	67845
PRO	PR:Q9C0B1
Proteomes	UP000005640
Bgee	Q9C0B1
CleanEx	HS_FTO
ExpressionAtlas	Q9C0B1
Genevestigator	Q9C0B1
GO	GO:0016607 GO:0005634 GO:0043734 GO:0008198 GO:0035516 GO:0035515 GO:0060612 GO:0006307 GO:0080111 GO:0070989 GO:0035552 GO:0035553 GO:0010883 GO:0040014 GO:0044065 GO:0070350 GO:0042245 GO:0001659
InterPro	IPR024366 IPR024367
Pfam	PF12934 PF12933

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005634	nucleus	PMID:30197295^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0035515	oxidative RNA demethylase activity	PMID:30197295^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0061157	mRNA destabilization	PMID:30197295^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035553	oxidative single-stranded RNA demethylation	PMID:30197295^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:1990984	tRNA demethylase activity	PMID:30197295^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:1990931	RNA N6-methyladenosine dioxygenase activity	PMID:30197295^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:28002401^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28002401^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0035515	oxidative RNA demethylase activity	PMID:28002401^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0061157	mRNA destabilization	PMID:28002401^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035553	oxidative single-stranded RNA demethylation	PMID:28002401^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035553	oxidative single-stranded RNA demethylation	PMID:26457839^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:1990931	RNA N6-methyladenosine dioxygenase activity	PMID:26457839^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:1990931	RNA N6-methyladenosine dioxygenase activity	PMID:25452335^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035553	oxidative single-stranded RNA demethylation	PMID:25452335^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:1990931	RNA N6-methyladenosine dioxygenase activity	PMID:26458103^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0090335	regulation of brown fat cell differentiation	PMID:26287746^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010883	regulation of lipid storage	PMID:26287746^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035553	oxidative single-stranded RNA demethylation	PMID:26458103^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26458103^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0080111	DNA demethylation	PMID:18775698^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070989	oxidative demethylation	PMID:18775698^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042245	RNA repair	PMID:18775698^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035553	oxidative single-stranded RNA demethylation	PMID:18775698^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035552	oxidative single-stranded DNA demethylation	PMID:18775698^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035516	oxidative DNA demethylase activity	PMID:18775698^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0035515	oxidative RNA demethylase activity	PMID:18775698^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006307	DNA dealkylation involved in DNA repair	PMID:18775698^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17991826^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BGW1	C	Seeded From UniProt	complete
enables	GO:0043734	DNA-N1-methyladenine dioxygenase activity	PMID:20376003^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035553	oxidative single-stranded RNA demethylation	PMID:22002720^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035552	oxidative single-stranded DNA demethylation	PMID:20376003^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035516	oxidative DNA demethylase activity	PMID:20376003^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0035515	oxidative RNA demethylase activity	PMID:22002720^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:22002720^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	PMID:20376003^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006307	DNA dealkylation involved in DNA repair	PMID:20376003^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0080111	DNA demethylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
involved_in	GO:0070989	oxidative demethylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
involved_in	GO:0070350	regulation of white fat cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
involved_in	GO:0060612	adipose tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
involved_in	GO:0044065	regulation of respiratory system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
enables	GO:0043734	DNA-N1-methyladenine dioxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	F	Seeded From UniProt	complete
involved_in	GO:0042245	RNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
involved_in	GO:0035553	oxidative single-stranded RNA demethylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
involved_in	GO:0035552	oxidative single-stranded DNA demethylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
enables	GO:0035516	oxidative DNA demethylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	F	Seeded From UniProt	complete
enables	GO:0035515	oxidative RNA demethylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	F	Seeded From UniProt	complete
involved_in	GO:0010883	regulation of lipid storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
involved_in	GO:0006307	DNA dealkylation involved in DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	C	Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BGW1 ensembl:ENSMUSP00000068380	P	Seeded From UniProt	complete
involved_in	GO:0006307	DNA dealkylation involved in DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032868	P	Seeded From UniProt	complete
enables	GO:0035515	oxidative RNA demethylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032868	F	Seeded From UniProt	complete
enables	GO:0035516	oxidative DNA demethylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032868	F	Seeded From UniProt	complete
involved_in	GO:0035552	oxidative single-stranded DNA demethylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032868	P	Seeded From UniProt	complete
involved_in	GO:0035553	oxidative single-stranded RNA demethylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032868	P	Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032868	P	Seeded From UniProt	complete
involved_in	GO:0042245	RNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032868	P	Seeded From UniProt	complete
involved_in	GO:0006307	DNA dealkylation involved in DNA repair	Reactome:R-HSA-73943	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8857692	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0223	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Wei, J et al. (2018) Differential mA, mA, and mA Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Mol. Cell 71 973-985.e5 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Mauer, J et al. (2017) Reversible methylation of mA in the 5' cap controls mRNA stability. Nature 541 371-375 PubMed GONUTS page
↑ ^3.0 ^3.1 Wang, T et al. (2015) Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein. J. Am. Chem. Soc. 137 13736-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Huang, Y et al. (2015) Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 43 373-84 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Zhou, J et al. (2015) Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature 526 591-4 PubMed GONUTS page
↑ ^6.0 ^6.1 Claussnitzer, M et al. (2015) FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. N. Engl. J. Med. 373 895-907 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Jia, G et al. (2008) Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 582 3313-9 PubMed GONUTS page
↑ Gerken, T et al. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318 1469-72 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Han, Z et al. (2010) Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464 1205-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Jia, G et al. (2011) N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 7 885-7 PubMed GONUTS page

[PMID:30197295-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Wei, J et al. (2018) Differential mA, mA, and mA Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Mol. Cell 71 973-985.e5 PubMed GONUTS page

[PMID:28002401-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Mauer, J et al. (2017) Reversible methylation of mA in the 5' cap controls mRNA stability. Nature 541 371-375 PubMed GONUTS page

[PMID:26457839-3] 3.0 ^3.1 Wang, T et al. (2015) Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein. J. Am. Chem. Soc. 137 13736-9 PubMed GONUTS page

[PMID:25452335-4] 4.0 ^4.1 Huang, Y et al. (2015) Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 43 373-84 PubMed GONUTS page

[PMID:26458103-5] 5.0 ^5.1 ^5.2 Zhou, J et al. (2015) Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature 526 591-4 PubMed GONUTS page

[PMID:26287746-6] 6.0 ^6.1 Claussnitzer, M et al. (2015) FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. N. Engl. J. Med. 373 895-907 PubMed GONUTS page

[PMID:18775698-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Jia, G et al. (2008) Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 582 3313-9 PubMed GONUTS page

[PMID:17991826-8] Gerken, T et al. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318 1469-72 PubMed GONUTS page

[PMID:20376003-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Han, Z et al. (2010) Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464 1205-9 PubMed GONUTS page

[PMID:22002720-10] 10.0 ^10.1 ^10.2 Jia, G et al. (2011) N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 7 885-7 PubMed GONUTS page

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HUMAN:FTO

Contents

Annotations

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References

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