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HUMAN:FOXP3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FOXP3 (synonyms: IPEX)
Protein Name(s) Forkhead box protein P3

Scurfin

External Links
UniProt Q9BZS1
EMBL AF277993
EF534714
EU855812
DQ010327
AF235097
BC113401
BC113403
BC143785
AJ005891
CCDS CCDS14323.1
CCDS48109.1
RefSeq NP_001107849.1
NP_054728.2
UniGene Hs.247700
PDB 3QRF
PDBsum 3QRF
ProteinModelPortal Q9BZS1
SMR Q9BZS1
BioGrid 119170
DIP DIP-36584N
IntAct Q9BZS1
STRING 9606.ENSP00000365380
PhosphoSite Q9BZS1
DMDM 14548061
PaxDb Q9BZS1
PRIDE Q9BZS1
DNASU 50943
Ensembl ENST00000376197
ENST00000376199
ENST00000376207
ENST00000518685
ENST00000557224
GeneID 50943
KEGG hsa:50943
UCSC uc004dne.4
uc004dnf.4
uc022bwa.1
CTD 50943
GeneCards GC0XM049106
GeneReviews FOXP3
HGNC HGNC:6106
HPA CAB026301
HPA045943
MIM 300292
304790
neXtProt NX_Q9BZS1
Orphanet 37042
PharmGKB PA201094
eggNOG COG5025
GeneTree ENSGT00750000117475
HOGENOM HOG000082490
HOVERGEN HBG051656
InParanoid Q9BZS1
KO K10163
OMA KHCQADH
OrthoDB EOG7M6D7G
PhylomeDB Q9BZS1
TreeFam TF326978
SignaLink Q9BZS1
EvolutionaryTrace Q9BZS1
GeneWiki FOXP3
GenomeRNAi 50943
NextBio 35482169
PRO PR:Q9BZS1
Proteomes UP000005640
Bgee Q9BZS1
CleanEx HS_FOXP3
ExpressionAtlas Q9BZS1
Genevestigator Q9BZS1
GO GO:0005737
GO:0005634
GO:0043234
GO:0035035
GO:0042826
GO:0046872
GO:0051059
GO:0051525
GO:0042803
GO:0003705
GO:0043565
GO:0003700
GO:0003714
GO:0001782
GO:0002361
GO:0006338
GO:0001816
GO:0002262
GO:0046007
GO:0008285
GO:0002677
GO:0032792
GO:0042036
GO:0050710
GO:0035067
GO:0031064
GO:0050777
GO:0045077
GO:0032689
GO:0032693
GO:0045085
GO:0032703
GO:0032713
GO:0032714
GO:0032715
GO:0048294
GO:0032088
GO:0043433
GO:0002725
GO:0042130
GO:0000122
GO:0045892
GO:0032720
GO:0032831
GO:0035066
GO:0033092
GO:0032753
GO:0002851
GO:0002669
GO:0045944
GO:0045893
GO:0032914
GO:0048302
GO:0006355
GO:0009615
GO:0042110
GO:0043029
GO:0002456
GO:0050852
GO:0002513
Gene3D 1.10.10.10
3.30.160.60
InterPro IPR001766
IPR018122
IPR011991
IPR007087
IPR015880
IPR013087
Pfam PF00250
PRINTS PR00053
SMART SM00339
SM00355
PROSITE PS00658
PS50039
PS00028

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001766

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q61660

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:21458306[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:21458306[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:21458306[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21458306[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

PMID:21458306[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051525

NFAT protein binding

PMID:21458306[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13469

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99JB6

F

Seeded From UniProt

complete

involved_in

GO:0002667

regulation of T cell anergy

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99JB6

P

Seeded From UniProt

complete

involved_in

GO:0032703

negative regulation of interleukin-2 production

PMID:17377532[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:22678915[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22678915[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22678915[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:23169781[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:23169781[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032703

negative regulation of interleukin-2 production

PMID:23169781[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032689

negative regulation of interferon-gamma production

PMID:23169781[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000320

negative regulation of T-helper 17 cell differentiation

PMID:23169781[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

PMID:23169781[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002725

negative regulation of T cell cytokine production

PMID:23169781[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032700

negative regulation of interleukin-17 production

PMID:18368049[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24012345[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19276356[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:19276356[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:17360565[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:19276356[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:17360565[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UKV0

F

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:17360565[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8WUI4

F

Seeded From UniProt

complete

involved_in

GO:0035066

positive regulation of histone acetylation

PMID:19276356[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0035035

histone acetyltransferase binding

PMID:17360565[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q92993

F

Seeded From UniProt

complete

involved_in

GO:0032703

negative regulation of interleukin-2 production

PMID:17360565[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031064

negative regulation of histone deacetylation

PMID:19276356[8]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P56524

P

Seeded From UniProt

complete

enables

GO:0051525

NFAT protein binding

PMID:16873067[10]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13469

F

Seeded From UniProt

complete

enables

GO:0051059

NF-kappaB binding

PMID:16652169[11]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050777

negative regulation of immune response

PMID:15652505[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050710

negative regulation of cytokine secretion

PMID:11483607[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046007

negative regulation of activated T cell proliferation

PMID:11483607[13]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:15466453[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P23772

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:16920951[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:11483607[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045085

negative regulation of interleukin-2 biosynthetic process

PMID:16873067[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:16873067[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:11483607[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

PMID:16873067[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:16903909[16]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043029

T cell homeostasis

PMID:11483607[13]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:16920951[15]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9BZS1

F

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

PMID:15466453[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042110

T cell activation

PMID:15466453[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042036

negative regulation of cytokine biosynthetic process

PMID:11483607[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032792

negative regulation of CREB transcription factor activity

PMID:16652169[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032713

negative regulation of interleukin-4 production

PMID:15466453[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032703

negative regulation of interleukin-2 production

PMID:15466453[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032693

negative regulation of interleukin-10 production

PMID:15466453[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032689

negative regulation of interferon-gamma production

PMID:15466453[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:16652169[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:20583921[17]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:15652505[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:11138001[18]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006338

chromatin remodeling

PMID:16903909[16]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16873067[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11483607[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16920951[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:11483607[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:11138001[18]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0002725

negative regulation of T cell cytokine production

PMID:15466453[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0050728

negative regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0050672

negative regulation of lymphocyte proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0048302

regulation of isotype switching to IgG isotypes

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0048294

negative regulation of isotype switching to IgE isotypes

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0045591

positive regulation of regulatory T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0045085

negative regulation of interleukin-2 biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0045077

negative regulation of interferon-gamma biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0045066

regulatory T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

F

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0042110

T cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0035067

negative regulation of histone acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0035066

positive regulation of histone acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0033092

positive regulation of immature T cell proliferation in thymus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032914

positive regulation of transforming growth factor beta1 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032831

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032753

positive regulation of interleukin-4 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032720

negative regulation of tumor necrosis factor production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032715

negative regulation of interleukin-6 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032714

negative regulation of interleukin-5 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032713

negative regulation of interleukin-4 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032703

negative regulation of interleukin-2 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032700

negative regulation of interleukin-17 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032693

negative regulation of interleukin-10 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0032689

negative regulation of interferon-gamma production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

F

Seeded From UniProt

complete

involved_in

GO:0002851

positive regulation of peripheral T cell tolerance induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0002677

negative regulation of chronic inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0002669

positive regulation of T cell anergy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0002667

regulation of T cell anergy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0002666

positive regulation of T cell tolerance induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0002637

regulation of immunoglobulin production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0002513

tolerance induction to self antigen

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0002507

tolerance induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0002456

T cell mediated immunity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0002361

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0002262

myeloid cell homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0001816

cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

involved_in

GO:0001782

B cell homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JB6
ensembl:ENSMUSP00000111405

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR030456

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR030456

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR030456

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16903909[16]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16903909[16]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16903909[16]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002362

CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment

PMID:18368049[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032831

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

PMID:18368049[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045589

regulation of regulatory T cell differentiation

Reactome:R-HSA-8877330

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030111

regulation of Wnt signaling pathway

Reactome:R-HSA-8939256

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8877879
Reactome:R-HSA-8877490
Reactome:R-HSA-8877414
Reactome:R-HSA-8877391
Reactome:R-HSA-8877369
Reactome:R-HSA-8877348
Reactome:R-HSA-8877192
Reactome:R-HSA-8865546

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Bandukwala, HS et al. (2011) Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity 34 479-91 PubMed GONUTS page
  3. Ono, M et al. (2007) Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 446 685-9 PubMed GONUTS page
  4. 4.0 4.1 4.2 Magg, T et al. (2012) Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells. Eur. J. Immunol. 42 1627-38 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 McMurchy, AN et al. (2013) A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells. Blood 121 1265-75 PubMed GONUTS page
  6. 6.0 6.1 6.2 Zhou, L et al. (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453 236-40 PubMed GONUTS page
  7. Xiao, J et al. (2013) PDCD5 negatively regulates autoimmunity by upregulating FOXP3(+) regulatory T cells and suppressing Th17 and Th1 responses. J. Autoimmun. 47 34-44 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Liu, R et al. (2009) FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus. Cancer Res. 69 2252-9 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 Li, B et al. (2007) FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc. Natl. Acad. Sci. U.S.A. 104 4571-6 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 Wu, Y et al. (2006) FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126 375-87 PubMed GONUTS page
  11. 11.0 11.1 11.2 Grant, C et al. (2006) Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways. PLoS Pathog. 2 e33 PubMed GONUTS page
  12. 12.0 12.1 Choi, BM et al. (2005) Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression. Biochem. Biophys. Res. Commun. 327 1066-71 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 13.4 13.5 13.6 13.7 Schubert, LA et al. (2001) Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 276 37672-9 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 14.5 14.6 14.7 Yagi, H et al. (2004) Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int. Immunol. 16 1643-56 PubMed GONUTS page
  15. 15.0 15.1 15.2 Lopes, JE et al. (2006) Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor. J. Immunol. 177 3133-42 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 16.4 Li, B et al. (2006) FOXP3 ensembles in T-cell regulation. Immunol. Rev. 212 99-113 PubMed GONUTS page
  17. Díaz, YR et al. (2010) T-bet, GATA-3, and Foxp3 expression and Th1/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) species. J. Infect. Dis. 202 406-15 PubMed GONUTS page
  18. 18.0 18.1 Brunkow, ME et al. (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27 68-73 PubMed GONUTS page