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HUMAN:FOXP3
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | FOXP3 (synonyms: IPEX) | |
Protein Name(s) | Forkhead box protein P3
Scurfin | |
External Links | ||
UniProt | Q9BZS1 | |
EMBL | AF277993 EF534714 EU855812 DQ010327 AF235097 BC113401 BC113403 BC143785 AJ005891 | |
CCDS | CCDS14323.1 CCDS48109.1 | |
RefSeq | NP_001107849.1 NP_054728.2 | |
UniGene | Hs.247700 | |
PDB | 3QRF | |
PDBsum | 3QRF | |
ProteinModelPortal | Q9BZS1 | |
SMR | Q9BZS1 | |
BioGrid | 119170 | |
DIP | DIP-36584N | |
IntAct | Q9BZS1 | |
STRING | 9606.ENSP00000365380 | |
PhosphoSite | Q9BZS1 | |
DMDM | 14548061 | |
PaxDb | Q9BZS1 | |
PRIDE | Q9BZS1 | |
DNASU | 50943 | |
Ensembl | ENST00000376197 ENST00000376199 ENST00000376207 ENST00000518685 ENST00000557224 | |
GeneID | 50943 | |
KEGG | hsa:50943 | |
UCSC | uc004dne.4 uc004dnf.4 uc022bwa.1 | |
CTD | 50943 | |
GeneCards | GC0XM049106 | |
GeneReviews | FOXP3 | |
HGNC | HGNC:6106 | |
HPA | CAB026301 HPA045943 | |
MIM | 300292 304790 | |
neXtProt | NX_Q9BZS1 | |
Orphanet | 37042 | |
PharmGKB | PA201094 | |
eggNOG | COG5025 | |
GeneTree | ENSGT00750000117475 | |
HOGENOM | HOG000082490 | |
HOVERGEN | HBG051656 | |
InParanoid | Q9BZS1 | |
KO | K10163 | |
OMA | KHCQADH | |
OrthoDB | EOG7M6D7G | |
PhylomeDB | Q9BZS1 | |
TreeFam | TF326978 | |
SignaLink | Q9BZS1 | |
EvolutionaryTrace | Q9BZS1 | |
GeneWiki | FOXP3 | |
GenomeRNAi | 50943 | |
NextBio | 35482169 | |
PRO | PR:Q9BZS1 | |
Proteomes | UP000005640 | |
Bgee | Q9BZS1 | |
CleanEx | HS_FOXP3 | |
ExpressionAtlas | Q9BZS1 | |
Genevestigator | Q9BZS1 | |
GO | GO:0005737 GO:0005634 GO:0043234 GO:0035035 GO:0042826 GO:0046872 GO:0051059 GO:0051525 GO:0042803 GO:0003705 GO:0043565 GO:0003700 GO:0003714 GO:0001782 GO:0002361 GO:0006338 GO:0001816 GO:0002262 GO:0046007 GO:0008285 GO:0002677 GO:0032792 GO:0042036 GO:0050710 GO:0035067 GO:0031064 GO:0050777 GO:0045077 GO:0032689 GO:0032693 GO:0045085 GO:0032703 GO:0032713 GO:0032714 GO:0032715 GO:0048294 GO:0032088 GO:0043433 GO:0002725 GO:0042130 GO:0000122 GO:0045892 GO:0032720 GO:0032831 GO:0035066 GO:0033092 GO:0032753 GO:0002851 GO:0002669 GO:0045944 GO:0045893 GO:0032914 GO:0048302 GO:0006355 GO:0009615 GO:0042110 GO:0043029 GO:0002456 GO:0050852 GO:0002513 | |
Gene3D | 1.10.10.10 3.30.160.60 | |
InterPro | IPR001766 IPR018122 IPR011991 IPR007087 IPR015880 IPR013087 | |
Pfam | PF00250 | |
PRINTS | PR00053 | |
SMART | SM00339 SM00355 | |
PROSITE | PS00658 PS50039 PS00028 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051525 |
NFAT protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002667 |
regulation of T cell anergy |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032703 |
negative regulation of interleukin-2 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032703 |
negative regulation of interleukin-2 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032689 |
negative regulation of interferon-gamma production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000320 |
negative regulation of T-helper 17 cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002725 |
negative regulation of T cell cytokine production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032700 |
negative regulation of interleukin-17 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042826 |
histone deacetylase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042826 |
histone deacetylase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035066 |
positive regulation of histone acetylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0035035 |
histone acetyltransferase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032703 |
negative regulation of interleukin-2 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031064 |
negative regulation of histone deacetylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051525 |
NFAT protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0051059 |
NF-kappaB binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050777 |
negative regulation of immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050710 |
negative regulation of cytokine secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046007 |
negative regulation of activated T cell proliferation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045085 |
negative regulation of interleukin-2 biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043029 |
T cell homeostasis |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042110 |
T cell activation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042036 |
negative regulation of cytokine biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032792 |
negative regulation of CREB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032713 |
negative regulation of interleukin-4 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032703 |
negative regulation of interleukin-2 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032693 |
negative regulation of interleukin-10 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032689 |
negative regulation of interferon-gamma production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009615 |
response to virus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006338 |
chromatin remodeling |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002725 |
negative regulation of T cell cytokine production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050852 |
T cell receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050672 |
negative regulation of lymphocyte proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048302 |
regulation of isotype switching to IgG isotypes |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048294 |
negative regulation of isotype switching to IgE isotypes |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045591 |
positive regulation of regulatory T cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045085 |
negative regulation of interleukin-2 biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045077 |
negative regulation of interferon-gamma biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045066 |
regulatory T cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042110 |
T cell activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035067 |
negative regulation of histone acetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035066 |
positive regulation of histone acetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033092 |
positive regulation of immature T cell proliferation in thymus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032914 |
positive regulation of transforming growth factor beta1 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032831 |
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032753 |
positive regulation of interleukin-4 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032714 |
negative regulation of interleukin-5 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032713 |
negative regulation of interleukin-4 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032703 |
negative regulation of interleukin-2 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032700 |
negative regulation of interleukin-17 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032693 |
negative regulation of interleukin-10 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032689 |
negative regulation of interferon-gamma production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002851 |
positive regulation of peripheral T cell tolerance induction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002677 |
negative regulation of chronic inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002669 |
positive regulation of T cell anergy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002667 |
regulation of T cell anergy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002666 |
positive regulation of T cell tolerance induction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002637 |
regulation of immunoglobulin production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002513 |
tolerance induction to self antigen |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002507 |
tolerance induction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002456 |
T cell mediated immunity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002361 |
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002262 |
myeloid cell homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001816 |
cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001782 |
B cell homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB6 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002362 |
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032831 |
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045589 |
regulation of regulatory T cell differentiation |
Reactome:R-HSA-8877330 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030111 |
regulation of Wnt signaling pathway |
Reactome:R-HSA-8939256 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-8877879 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Bandukwala, HS et al. (2011) Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity 34 479-91 PubMed GONUTS page
- ↑ Ono, M et al. (2007) Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 446 685-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Magg, T et al. (2012) Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells. Eur. J. Immunol. 42 1627-38 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 McMurchy, AN et al. (2013) A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells. Blood 121 1265-75 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Zhou, L et al. (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453 236-40 PubMed GONUTS page
- ↑ Xiao, J et al. (2013) PDCD5 negatively regulates autoimmunity by upregulating FOXP3(+) regulatory T cells and suppressing Th17 and Th1 responses. J. Autoimmun. 47 34-44 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Liu, R et al. (2009) FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus. Cancer Res. 69 2252-9 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Li, B et al. (2007) FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc. Natl. Acad. Sci. U.S.A. 104 4571-6 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 Wu, Y et al. (2006) FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126 375-87 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Grant, C et al. (2006) Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways. PLoS Pathog. 2 e33 PubMed GONUTS page
- ↑ 12.0 12.1 Choi, BM et al. (2005) Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression. Biochem. Biophys. Res. Commun. 327 1066-71 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 13.5 13.6 13.7 Schubert, LA et al. (2001) Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 276 37672-9 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 14.5 14.6 14.7 Yagi, H et al. (2004) Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int. Immunol. 16 1643-56 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Lopes, JE et al. (2006) Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor. J. Immunol. 177 3133-42 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 16.4 Li, B et al. (2006) FOXP3 ensembles in T-cell regulation. Immunol. Rev. 212 99-113 PubMed GONUTS page
- ↑ Díaz, YR et al. (2010) T-bet, GATA-3, and Foxp3 expression and Th1/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) species. J. Infect. Dis. 202 406-15 PubMed GONUTS page
- ↑ 18.0 18.1 Brunkow, ME et al. (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27 68-73 PubMed GONUTS page
c
d
h
n
- GO:0010629 ! negative regulation of gene expression
- GO:0032714 ! negative regulation of interleukin-5 production
- GO:0050777 ! negative regulation of immune response
- GO:0002677 ! negative regulation of chronic inflammatory response
- GO:0045077 ! negative regulation of interferon-gamma biosynthetic process
- GO:0032700 ! negative regulation of interleukin-17 production
- GO:0048294 ! negative regulation of isotype switching to IgE isotypes
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0050672 ! negative regulation of lymphocyte proliferation
- GO:0050728 ! negative regulation of inflammatory response
- GO:0002725 ! negative regulation of T cell cytokine production
- GO:2000320 ! negative regulation of T-helper 17 cell differentiation
- GO:0032689 ! negative regulation of type II interferon production
- GO:0032720 ! negative regulation of tumor necrosis factor production
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0032703 ! negative regulation of interleukin-2 production
- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:0032693 ! negative regulation of interleukin-10 production
- GO:0032713 ! negative regulation of interleukin-4 production
- GO:0032792 ! negative regulation of CREB transcription factor activity
- GO:0042036 ! negative regulation of cytokine biosynthetic process
- GO:0042130 ! negative regulation of T cell proliferation
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0043433 ! negative regulation of DNA-binding transcription factor activity
- GO:0045085 ! negative regulation of interleukin-2 biosynthetic process
- GO:0046007 ! negative regulation of activated T cell proliferation
- GO:0050710 ! negative regulation of cytokine secretion
- GO:0032715 ! negative regulation of interleukin-6 production
- GO:0051059 ! NF-kappaB binding
- GO:0051525 ! NFAT protein binding
- GO:0003676 ! nucleic acid binding
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
p
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0032831 ! positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- GO:0032753 ! positive regulation of interleukin-4 production
- GO:0045591 ! positive regulation of regulatory T cell differentiation
- GO:0002851 ! positive regulation of peripheral T cell tolerance induction
- GO:0032914 ! positive regulation of transforming growth factor beta1 production
- GO:0033092 ! positive regulation of immature T cell proliferation in thymus
- GO:0002666 ! positive regulation of T cell tolerance induction
- GO:0002669 ! positive regulation of T cell anergy
- GO:0010628 ! positive regulation of gene expression
- Primates
- GO:0032991 ! protein-containing complex
- GO:0042803 ! protein homodimerization activity
r
- GO:0002667 ! regulation of T cell anergy
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0006357 ! regulation of transcription by RNA polymerase II
- GO:0002637 ! regulation of immunoglobulin production
- GO:0030111 ! regulation of Wnt signaling pathway
- GO:0045589 ! regulation of regulatory T cell differentiation
- GO:0048302 ! regulation of isotype switching to IgG isotypes
- GO:0045066 ! regulatory T cell differentiation
- GO:0009615 ! response to virus
- GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding
t