HUMAN:FOXH1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FOXH1 (synonyms: FAST1, FAST2)
Protein Name(s)	Forkhead box protein H1 Forkhead activin signal transducer 1 Fast-1 hFAST-1 Forkhead activin signal transducer 2 Fast-2
External Links
UniProt	O75593
EMBL	AF076292 CH471162 CH471162
CCDS	CCDS6428.1
RefSeq	NP_003914.1
UniGene	Hs.708365
ProteinModelPortal	O75593
SMR	O75593
BioGrid	114442
IntAct	O75593
MINT	MINT-199205
STRING	9606.ENSP00000366534
PaxDb	O75593
PRIDE	O75593
DNASU	8928
Ensembl	ENST00000377317
GeneID	8928
KEGG	hsa:8928
UCSC	uc003zdc.3
CTD	8928
GeneCards	GC08M145698
GeneReviews	FOXH1
HGNC	HGNC:3814
MIM	603621
neXtProt	NX_O75593
Orphanet	93925 93924 280200 93926 220386 280195
PharmGKB	PA28231
eggNOG	COG5025
GeneTree	ENSGT00760000118794
HOGENOM	HOG000112630
HOVERGEN	HBG051647
InParanoid	O75593
KO	K09400
OMA	SERPLWP
OrthoDB	EOG76HQ1T
PhylomeDB	O75593
TreeFam	TF350620
Reactome	REACT_111057 REACT_150238
SignaLink	O75593
GeneWiki	FOXH1
GenomeRNAi	8928
NextBio	33570
PRO	PR:O75593
Proteomes	UP000005640
Bgee	O75593
CleanEx	HS_FOXH1
Genevestigator	O75593
GO	GO:0032444 GO:0000790 GO:0005654 GO:0005634 GO:0005667 GO:0050681 GO:0043425 GO:0070410 GO:0035326 GO:0019904 GO:0070412 GO:0001205 GO:0001104 GO:0001190 GO:0043565 GO:0003700 GO:0046332 GO:0044212 GO:0035909 GO:0048318 GO:0003215 GO:0035054 GO:0001947 GO:2000824 GO:0060766 GO:0033147 GO:1900164 GO:0003151 GO:0045944 GO:0045893 GO:0003139 GO:0007179 GO:0003222
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001766	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q61660	F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:16120611^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	PMID:17507406^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:9702198^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:9389648^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:16120611^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	PMID:16120611^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060766	negative regulation of androgen receptor signaling pathway	PMID:16120611^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	PMID:16120611^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21828274^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F	occurs_in:(CL:0002322)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9389648^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88621	F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:21828274^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99081	F	occurs_in:(CL:0002322)\|occurs_in:(UBERON:0000925)	Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:21828274^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15923	F	occurs_in:(CL:0002322)\|occurs_in:(UBERON:0000925)	Seeded From UniProt	complete
enables	GO:0035326	enhancer binding	PMID:21828274^[6]	ECO:0000305	curator inference used in manual assertion	GO:0000790	F	part_of:(CL:0002322) has_input:(ENSEMBL:ENSG00000243709)	Seeded From UniProt	complete
involved_in	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	PMID:16120611^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	PMID:9389648^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88621	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17438144^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16120611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0003700	DNA-binding transcription factor activity	PMID:17438144^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17507406^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_regulation_target:(UniProtKB:Q9PWB0)	Seeded From UniProt	complete
contributes_to	GO:0003677	DNA binding	PMID:9389648^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21828274^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000925)\|part_of:(CL:0002322)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9702198^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9702198^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9702198^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:9702198^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9702198^[4]	ECO:0000305	curator inference used in manual assertion	GO:0043565	C		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	PMID:14671321^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14671321^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	F		Seeded From UniProt	complete
involved_in	GO:0048318	axial mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	F		Seeded From UniProt	complete
involved_in	GO:0035909	aorta morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
involved_in	GO:0035054	embryonic heart tube anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	C		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	F		Seeded From UniProt	complete
involved_in	GO:0003222	ventricular trabecula myocardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
involved_in	GO:0003139	secondary heart field specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88621 ensembl:ENSMUSP00000036591	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:9702198^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-1225919	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Chen, G et al. (2005) Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor. J. Biol. Chem. 280 36355-63 PubMed GONUTS page
↑ ^3.0 ^3.1 Tavares, AT et al. (2007) Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development 134 2051-60 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Zhou, S et al. (1998) Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol. Cell 2 121-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Yoon, SJ et al. (2011) HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25 1654-61 PubMed GONUTS page
↑ ^7.0 ^7.1 Zhang, S et al. (2007) Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol. Cell. Biol. 27 4488-99 PubMed GONUTS page
↑ ^8.0 ^8.1 Chiba, S et al. (2003) Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. Proc. Natl. Acad. Sci. U.S.A. 100 15577-82 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:16120611-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Chen, G et al. (2005) Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor. J. Biol. Chem. 280 36355-63 PubMed GONUTS page

[PMID:17507406-3] 3.0 ^3.1 Tavares, AT et al. (2007) Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development 134 2051-60 PubMed GONUTS page

[PMID:9702198-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Zhou, S et al. (1998) Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol. Cell 2 121-7 PubMed GONUTS page

[PMID:9389648-5] 5.0 ^5.1 ^5.2 ^5.3 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page

[PMID:21828274-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Yoon, SJ et al. (2011) HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25 1654-61 PubMed GONUTS page

[PMID:17438144-7] 7.0 ^7.1 Zhang, S et al. (2007) Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol. Cell. Biol. 27 4488-99 PubMed GONUTS page

[PMID:14671321-8] 8.0 ^8.1 Chiba, S et al. (2003) Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. Proc. Natl. Acad. Sci. U.S.A. 100 15577-82 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

HUMAN:FOXH1

Contents

Annotations

Notes

References

a

b

c

d

e

h

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools