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HUMAN:FOSL2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FOSL2 (synonyms: FRA2)
Protein Name(s) Fos-related antigen 2

FRA-2

External Links
UniProt P15408
EMBL X16706
AK055579
AK302622
AK315415
BX647822
CR542262
AC104695
CH471053
CH471053
BC022791
CCDS CCDS1766.1
PIR S15749
RefSeq NP_005244.1
UniGene Hs.220971
Hs.596972
ProteinModelPortal P15408
SMR P15408
BioGrid 108638
DIP DIP-48788N
IntAct P15408
STRING 9606.ENSP00000264716
PhosphoSite P15408
DMDM 120487
MaxQB P15408
PaxDb P15408
PRIDE P15408
DNASU 2355
Ensembl ENST00000264716
ENST00000379619
GeneID 2355
KEGG hsa:2355
UCSC uc002rma.3
uc021vfg.1
CTD 2355
GeneCards GC02P028615
HGNC HGNC:3798
HPA CAB013460
HPA004817
MIM 601575
neXtProt NX_P15408
PharmGKB PA28215
eggNOG NOG301361
GeneTree ENSGT00730000110541
HOGENOM HOG000234334
HOVERGEN HBG005743
InParanoid P15408
KO K09030
OMA PYSRSHP
OrthoDB EOG761BVN
PhylomeDB P15408
TreeFam TF326301
ChiTaRS FOSL2
GeneWiki FOSL2
GenomeRNAi 2355
NextBio 9551
PRO PR:P15408
Proteomes UP000005640
Bgee P15408
CleanEx HS_FOSL2
ExpressionAtlas P15408
Genevestigator P15408
GO GO:0005634
GO:0003690
GO:0000977
GO:0003700
GO:0008219
GO:0032870
GO:0007565
GO:0048146
GO:0006357
GO:0051591
GO:0051412
GO:0042493
GO:0009612
GO:0043278
GO:0032570
GO:0006366
InterPro IPR000837
IPR004827
IPR029814
PANTHER PTHR23351
PTHR23351:SF25
Pfam PF00170
PRINTS PR00042
SMART SM00338
PROSITE PS50217
PS00036

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR004827

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P13346

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:13679379[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:13679379[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:8061)

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:13679379[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001297
MGI:MGI:102858
MGI:MGI:109384
MGI:MGI:1859147
MGI:MGI:1932093
MGI:MGI:95574
PANTHER:PTN001156258
RGD:1308198
RGD:2626
RGD:2627
RGD:2628
UniProtKB:P01100
UniProtKB:P18847
UniProtKB:P53539
WB:WBGene00001345

C

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109384
MGI:MGI:1859147
MGI:MGI:1932093
MGI:MGI:95574
MGI:MGI:95575
PANTHER:PTN001156258
RGD:2627
UniProtKB:P15407
UniProtKB:Q9NR55

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048146

positive regulation of fibroblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47930
ensembl:ENSMUSP00000031017

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47930
ensembl:ENSMUSP00000031017

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47930
ensembl:ENSMUSP00000031017

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47930
ensembl:ENSMUSP00000031017

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47930
ensembl:ENSMUSP00000031017

F

Seeded From UniProt

complete

involved_in

GO:0003334

keratinocyte development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47930
ensembl:ENSMUSP00000031017

P

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47930
ensembl:ENSMUSP00000031017

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000837
InterPro:IPR029814

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000837
InterPro:IPR004827

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004827

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000837
InterPro:IPR029814

P

Seeded From UniProt

complete

involved_in

GO:0008219

cell death

PMID:8954781[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:8954781[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8954781[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:8954781[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Adiseshaiah, P et al. (2003) Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells. J. Biol. Chem. 278 47423-33 PubMed GONUTS page
  3. ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Molven, A et al. (1996) Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. Genomics 38 72-5 PubMed GONUTS page
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