HUMAN:FOLR1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FOLR1 (synonyms: FOLR)
Protein Name(s)	Folate receptor alpha FR-alpha Adult folate-binding protein FBP Folate receptor 1 Folate receptor, adult KB cells FBP Ovarian tumor-associated antigen MOv18
External Links
UniProt	P15328
EMBL	J05013 M28099 X62753 U20391 U78793 U78794 BT007158 CR542019 AK223527 CH471076 BC002947 M25317
CCDS	CCDS8211.1
PIR	A44904
RefSeq	NP_000793.1 NP_057936.1 NP_057937.1 NP_057941.1
UniGene	Hs.73769
PDB	4KM6 4KM7 4KMX 4LRH
PDBsum	4KM6 4KM7 4KMX 4LRH
ProteinModelPortal	P15328
SMR	P15328
BioGrid	108631
IntAct	P15328
STRING	9606.ENSP00000308137
BindingDB	P15328
ChEMBL	CHEMBL2121
DrugBank	DB00563
TCDB	9.B.92.1.1
DMDM	544337
MaxQB	P15328
PaxDb	P15328
PeptideAtlas	P15328
PRIDE	P15328
DNASU	2348
Ensembl	ENST00000312293 ENST00000393676 ENST00000393679 ENST00000393681
GeneID	2348
KEGG	hsa:2348
UCSC	uc001orz.2
CTD	2348
GeneCards	GC11P071900
HGNC	HGNC:3791
MIM	136430 613068
neXtProt	NX_P15328
Orphanet	217382
PharmGKB	PA28207
eggNOG	NOG26606
GeneTree	ENSGT00390000010470
HOGENOM	HOG000006539
HOVERGEN	HBG039612
InParanoid	P15328
KO	K13649
OMA	NWTSGFN
OrthoDB	EOG7K6PW3
PhylomeDB	P15328
TreeFam	TF328532
GeneWiki	Folate_receptor_1
GenomeRNAi	2348
NextBio	9519
PRO	PR:P15328
Proteomes	UP000005640
Bgee	P15328
CleanEx	HS_FOLR1
ExpressionAtlas	P15328
Genevestigator	P15328
GO	GO:0031362 GO:0016324 GO:0031526 GO:0009986 GO:0030136 GO:0005768 GO:0070062 GO:0005887 GO:0016020 GO:0005886 GO:0005542 GO:0008517 GO:0004872 GO:0046655 GO:0015884 GO:0006898
InterPro	IPR004269 IPR018143
PANTHER	PTHR10517
Pfam	PF03024

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:23243496^[1]	ECO:0000314			C		Figure 1 shows nuclear localization of FRα.	complete CACAO 7872
	GO:0005667	transcription factor complex	PMID:23243496^[1]	ECO:0000314			C		Figure 2 and 3 show FRα acting as a transcription factor	complete CACAO 7874
enables	GO:0008144	drug binding	PMID:19116913^[2]	ECO:0000353	physical interaction evidence used in manual assertion	CHEBI:63720	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:10787414^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000351)	Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	PMID:10787414^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000351) occurs_in:(UBERON:0001987) occurs_in:(GO:0016324)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:10787414^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002586)	Seeded From UniProt	complete
involved_in	GO:0031103	axon regeneration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35846	P	part_of:(GO:0048678)	Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35846	P		Seeded From UniProt	complete
involved_in	GO:0061626	pharyngeal arch artery morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35846	P	part_of:(UBERON:0000068)	Seeded From UniProt	complete
involved_in	GO:0003147	neural crest cell migration involved in heart formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35846	P	part_of:(UBERON:0000068)	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35846	P	part_of:(UBERON:0000068)	Seeded From UniProt	complete
involved_in	GO:0060828	regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35846	P		Seeded From UniProt	complete
involved_in	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35846	P		Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	PMID:14722620^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071231	cellular response to folic acid	PMID:14722620^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051870	methotrexate binding	PMID:19116913^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061713	anterior neural tube closure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35846	P		Seeded From UniProt	complete
enables	GO:0061714	folic acid receptor activity	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0005542,GO:0015884	F	occurs_in:(CL:0000351) occurs_in:(UBERON:0001987)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23243496^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19581412^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0031362	anchored component of external side of plasma membrane	PMID:8033114^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031362	anchored component of external side of plasma membrane	PMID:2527252^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015884	folic acid transport	PMID:8033114^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061714	folic acid receptor activity	PMID:8033114^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:1840502^[10]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	PMID:23851396^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	PMID:2527252^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	PMID:1840502^[10]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1929185 PANTHER:PTN001314841 UniProtKB:A6ND01	F		Seeded From UniProt	complete
part_of	GO:0031362	anchored component of external side of plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001314841 UniProtKB:P14207 UniProtKB:P15328	C		Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000054922 RGD:71032 UniProtKB:P15328	F		Seeded From UniProt	complete
part_of	GO:0046658	anchored component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V8M6 ensembl:ENSRNOP00000071311	C		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V8M6 ensembl:ENSRNOP00000071311	C		Seeded From UniProt	complete
part_of	GO:0005903	brush border	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V8M6 ensembl:ENSRNOP00000071311	C		Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V8M6 ensembl:ENSRNOP00000071311	F		Seeded From UniProt	complete
involved_in	GO:0061713	anterior neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35846 ensembl:ENSMUSP00000102598	P		Seeded From UniProt	complete
involved_in	GO:0061626	pharyngeal arch artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35846 ensembl:ENSMUSP00000102598	P		Seeded From UniProt	complete
involved_in	GO:0060828	regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35846 ensembl:ENSMUSP00000102598	P		Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35846 ensembl:ENSMUSP00000102598	P		Seeded From UniProt	complete
involved_in	GO:0046655	folic acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35846 ensembl:ENSMUSP00000102598	P		Seeded From UniProt	complete
involved_in	GO:0031103	axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35846 ensembl:ENSMUSP00000102598	P		Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35846 ensembl:ENSMUSP00000102598	P		Seeded From UniProt	complete
involved_in	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35846 ensembl:ENSMUSP00000102598	P		Seeded From UniProt	complete
involved_in	GO:0003147	neural crest cell migration involved in heart formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35846 ensembl:ENSMUSP00000102598	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35846 ensembl:ENSMUSP00000102598	P		Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032935	F		Seeded From UniProt	complete
enables	GO:0061714	folic acid receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032935	F		Seeded From UniProt	complete
involved_in	GO:1904447	folate import across plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032935	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:2768245^[13] PMID:10633085^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015884	folic acid transport	PMID:9545095^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	PMID:9545095^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	PMID:9545095^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:10633085^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048208	COPII vesicle coating	Reactome:R-HSA-204005	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	Reactome:R-HSA-6807877 Reactome:R-HSA-6807875 Reactome:R-HSA-5694446	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	Reactome:R-HSA-6809006 Reactome:R-HSA-6809003 Reactome:R-HSA-6807877	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0012507	ER to Golgi transport vesicle membrane	Reactome:R-HSA-5694446 Reactome:R-HSA-5694441 Reactome:R-HSA-5694439 Reactome:R-HSA-5694418 Reactome:R-HSA-5694409 Reactome:R-HSA-203973	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	Reactome:R-HSA-199977	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-5694527 Reactome:R-HSA-5694522 Reactome:R-HSA-5694417 Reactome:R-HSA-5694410 Reactome:R-HSA-204008 Reactome:R-HSA-203973	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-6809011 Reactome:R-HSA-6809010 Reactome:R-HSA-6809006	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0290	F		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0070	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Boshnjaku, V et al. (2012) Nuclear localization of folate receptor alpha: a new role as a transcription factor. Sci Rep 2 980 PubMed GONUTS page
↑ ^2.0 ^2.1 van der Heijden, JW et al. (2009) Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients. Arthritis Rheum. 60 12-21 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Chancy, CD et al. (2000) Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium. J. Biol. Chem. 275 20676-84 PubMed GONUTS page
↑ ^4.0 ^4.1 Antony, A et al. (2004) Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions. J. Clin. Invest. 113 285-301 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Orr, RB & Kamen, BA (1994) UMSCC38 cells amplified at 11q13 for the folate receptor synthesize a mutant nonfunctional folate receptor. Cancer Res. 54 3905-11 PubMed GONUTS page
↑ ^9.0 ^9.1 Lacey, SW et al. (1989) Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol. J. Clin. Invest. 84 715-20 PubMed GONUTS page
↑ ^10.0 ^10.1 Coney, LR et al. (1991) Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. Cancer Res. 51 6125-32 PubMed GONUTS page
↑ Chen, C et al. (2013) Structural basis for molecular recognition of folic acid by folate receptors. Nature 500 486-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Elwood, PC (1989) Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells. J. Biol. Chem. 264 14893-901 PubMed GONUTS page
↑ ^14.0 ^14.1 Miotti, S et al. (2000) Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1. J. Cell. Sci. 113 Pt 2 349-57 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Barber, RC et al. (1998) Lack of association between mutations in the folate receptor-alpha gene and spina bifida. Am. J. Med. Genet. 76 310-7 PubMed GONUTS page

[PMID:23243496-1] 1.0 ^1.1 ^1.2 Boshnjaku, V et al. (2012) Nuclear localization of folate receptor alpha: a new role as a transcription factor. Sci Rep 2 980 PubMed GONUTS page

[PMID:19116913-2] 2.0 ^2.1 van der Heijden, JW et al. (2009) Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients. Arthritis Rheum. 60 12-21 PubMed GONUTS page

[PMID:10787414-3] 3.0 ^3.1 ^3.2 Chancy, CD et al. (2000) Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium. J. Biol. Chem. 275 20676-84 PubMed GONUTS page

[PMID:14722620-4] 4.0 ^4.1 Antony, A et al. (2004) Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions. J. Clin. Invest. 113 285-301 PubMed GONUTS page

[PMID:23533145-5] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19581412-6] Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page

[PMID:19199708-7] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:8033114-8] 8.0 ^8.1 ^8.2 Orr, RB & Kamen, BA (1994) UMSCC38 cells amplified at 11q13 for the folate receptor synthesize a mutant nonfunctional folate receptor. Cancer Res. 54 3905-11 PubMed GONUTS page

[PMID:2527252-9] 9.0 ^9.1 Lacey, SW et al. (1989) Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol. J. Clin. Invest. 84 715-20 PubMed GONUTS page

[PMID:1840502-10] 10.0 ^10.1 Coney, LR et al. (1991) Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. Cancer Res. 51 6125-32 PubMed GONUTS page

[PMID:23851396-11] Chen, C et al. (2013) Structural basis for molecular recognition of folic acid by folate receptors. Nature 500 486-9 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2768245-13] Elwood, PC (1989) Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells. J. Biol. Chem. 264 14893-901 PubMed GONUTS page

[PMID:10633085-14] 14.0 ^14.1 Miotti, S et al. (2000) Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1. J. Cell. Sci. 113 Pt 2 349-57 PubMed GONUTS page

[PMID:9545095-15] 15.0 ^15.1 ^15.2 Barber, RC et al. (1998) Lack of association between mutations in the folate receptor-alpha gene and spina bifida. Am. J. Med. Genet. 76 310-7 PubMed GONUTS page

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HUMAN:FOLR1

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References

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