Category:GO:0051870 ! methotrexate binding

id: GO:0051870

name: methotrexate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA." [GOC:nln]
is_a: GO:0008144 ! drug binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0033218 ! amide binding
is_a: GO:0043177 ! organic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

AmiGO <GOterm>GO:0051870</GOterm>
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