GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:23243496
| Citation |
Boshnjaku, V, Shim, KW, Tsurubuchi, T, Ichi, S, Szany, EV, Xi, G, Mania-Farnell, B, McLone, DG, Tomita, T and Mayanil, CS (2012) Nuclear localization of folate receptor alpha: a new role as a transcription factor. Sci Rep 2:980 |
|---|---|
| Abstract |
Folic acid (FA) has traditionally been associated with prevention of neural tube defects; more recent work suggests that it may also be involved in in the prevention of adult onset diseases. As the role of FA in human health and disease expands, it also becomes more critical to understand the mechanisms behind FA action. In this work we examined the hypothesis that folate receptor alpha (FRα) acts as a transcription factor. FRα is a GPI-anchored protein and a component of the caveolae fraction. The work described here shows that FRα translocates to the nucleus, where it binds to cis-regulatory elements at promoter regions of Fgfr4 and Hes1, and regulates their expression. The FRα recognition domain mapped to AT rich regions on the promoters. Until this time FRα has only been considered as a folate transporter, these studies describe a novel role for FRα as a transcription factor. |
| Links |
PubMed PMC3522071 Online version:10.1038/srep00980 |
| Keywords |
Animals; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; Cell Line, Tumor; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Consensus Sequence; Folate Receptor 1/metabolism; Folic Acid/pharmacology; Humans; Mice; Promoter Regions, Genetic; Protein Binding; Receptor, Fibroblast Growth Factor, Type 4/genetics; Receptor, Fibroblast Growth Factor, Type 4/metabolism; Regulatory Elements, Transcriptional; Transfection |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005634: nucleus |
ECO:0000314: |
C |
Figure 1 shows nuclear localization of FRα. |
complete | ||||
| GO:0005667: transcription factor complex |
ECO:0000314: |
C |
Figure 2 and 3 show FRα acting as a transcription factor |
complete | ||||
|
part_of |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
See Help:References for how to manage references in GONUTS.
