HUMAN:FGFR3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FGFR3 (synonyms: JTK4)
Protein Name(s)	Fibroblast growth factor receptor 3 FGFR-3
External Links
UniProt	P22607
EMBL	M58051 AF245114 AB209441 AY768549 AC016773 CH471131 CH471131 CH471131 CH471131 M64347 M59374 S76733 X84939 U22410
CCDS	CCDS3353.1 CCDS3354.1 CCDS54706.1
PIR	A38576
RefSeq	NP_000133.1 NP_001156685.1 NP_075254.1
UniGene	Hs.1420
PDB	1RY7 2LZL 4K33
PDBsum	1RY7 2LZL 4K33
ProteinModelPortal	P22607
SMR	P22607
BioGrid	108552
DIP	DIP-4016N
IntAct	P22607
MINT	MINT-1034697
STRING	9606.ENSP00000260795
BindingDB	P22607
ChEMBL	CHEMBL2742
DrugBank	DB00039 DB06589 DB08901
GuidetoPHARMACOLOGY	1810
PhosphoSite	P22607
DMDM	120050
PaxDb	P22607
PRIDE	P22607
DNASU	2261
Ensembl	ENST00000260795 ENST00000340107 ENST00000352904 ENST00000412135 ENST00000440486
GeneID	2261
KEGG	hsa:2261
UCSC	uc003gdr.3 uc003gds.3 uc003gdu.2
CTD	2261
GeneCards	GC04P001795
GeneReviews	FGFR3
HGNC	HGNC:3690
HPA	CAB004231
MIM	100800 109800 134934 146000 149730 162900 182000 187600 187601 254500 273300 602849 603956 610474 612247
neXtProt	NX_P22607
Orphanet	15 85164 93262 1555 251579 251576 429 35099 2343 35098 2363 53271 794 85165 1860 93274
PharmGKB	PA28129
eggNOG	COG0515
GeneTree	ENSGT00760000118923
HOGENOM	HOG000263410
HOVERGEN	HBG000345
InParanoid	P22607
KO	K05094
OMA	VFTHDLL
PhylomeDB	P22607
TreeFam	TF316307
BRENDA	2.7.10.1
Reactome	REACT_111184 REACT_121011 REACT_121249 REACT_121337 REACT_121398 REACT_147727 REACT_21247 REACT_21270 REACT_21310 REACT_21374 REACT_75829 REACT_9508 REACT_9510 REACT_976
SignaLink	P22607
ChiTaRS	FGFR3
EvolutionaryTrace	P22607
GeneWiki	Fibroblast_growth_factor_receptor_3
GenomeRNAi	2261
NextBio	9179
PRO	PR:P22607
Proteomes	UP000005640
Bgee	P22607
CleanEx	HS_FGFR3
ExpressionAtlas	P22607
Genevestigator	P22607
GO	GO:0009986 GO:0016023 GO:0009898 GO:0005783 GO:0005576 GO:0005887 GO:0005764 GO:0005634 GO:0048471 GO:0005886 GO:0005524 GO:0017134 GO:0005007 GO:0004713 GO:0061144 GO:0060385 GO:0070977 GO:0030282 GO:0060349 GO:0007267 GO:0022010 GO:0002062 GO:0035988 GO:0090102 GO:0048546 GO:0003416 GO:0001958 GO:0007173 GO:0072148 GO:0038095 GO:1902178 GO:0008543 GO:0030900 GO:0045087 GO:0060113 GO:0008286 GO:0007259 GO:0070307 GO:0002089 GO:0000165 GO:0002009 GO:0048712 GO:0048640 GO:0050680 GO:0045839 GO:0045879 GO:0000122 GO:0048011 GO:0018108 GO:0048015 GO:0090263 GO:0045597 GO:0008284 GO:0001938 GO:0070374 GO:0043410 GO:0090080 GO:0043525 GO:0043552 GO:0010518 GO:0031398 GO:0042511 GO:0042517 GO:0046777 GO:0048678 GO:0001501 GO:0035019 GO:0021762
Gene3D	2.60.40.10
InterPro	IPR028176 IPR016248 IPR007110 IPR013783 IPR013098 IPR003599 IPR003598 IPR013151 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635
PANTHER	PTHR24416:SF128
Pfam	PF07679 PF00047 PF07714
PIRSF	PIRSF000628
PRINTS	PR00109
SMART	SM00409 SM00408 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0060348	bone development	PMID:20582225^[1]	ECO:0000315			P	Figure 4b and c: homozygous Fgfr3 null mice showed increased length of long bone.	complete
	GO:0070977	bone maturation	PMID:20582225^[1]	ECO:0000315			P	Figure 4c: Decrease in bone density resulting from the knock out of fgfr3 in fgfr3 null homozygous mice.	complete
	GO:0016458	gene silencing	PMID:20582225^[1]	ECO:0000269			P	Tissue-specific inactivation of the Fgfr3 conditional allele by a Col2a1-Cre transgene in tissues containing cartilage was revealed by PCR analysis.	complete
	GO:0035121	tail morphogenesis	PMID:20582225^[1]	ECO:0000315			P	Fgfr3floxneo/floxneo mice showed kinky tails, which is also found in Fgfr3 knock out mice.	complete
	GO:0045926	negative regulation of growth	PMID:20582225^[1]	ECO:0000315			P	Figure 4b and c: homozygous Fgfr3 null mice showed increased length of long bone.	complete
part_of	GO:0030133	transport vesicle	PMID:18061161^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:18061161^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18061161^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070977	bone maturation	PMID:20582225^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61851	P	Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	PMID:20582225^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61851	P	Seeded From UniProt	complete
involved_in	GO:0048640	negative regulation of developmental growth	PMID:20582225^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61851	P	Seeded From UniProt	complete
involved_in	GO:0030282	bone mineralization	PMID:20582225^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61851	P	Seeded From UniProt	complete
involved_in	GO:1902178	fibroblast growth factor receptor apoptotic signaling pathway	PMID:17561467^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:11294897^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:11294897^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:11294897^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:11294897^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:17561467^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:11294897^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:11294897^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:8663044^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010518	positive regulation of phospholipase activity	PMID:17561467^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:11294897^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8663044^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:8663044^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:11294897^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95524 PANTHER:PTN002814671 UniProtKB:P22607	P	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C	Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95523 PANTHER:PTN000699279 RGD:2611 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 ZFIN:ZDB-GENE-030323-1	F	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 PANTHER:PTN001230353 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607	P	Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C	Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95524 PANTHER:PTN000699279 RGD:2611 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 ZFIN:ZDB-GENE-980526-255	F	Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P55075	P	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P31371	P	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12304	P	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09038	P	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08620	P	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05230	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P55075	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P31371	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12304	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09038	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08620	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05230	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24120763^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22607	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23972473^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22607	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:14732692^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22607	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K210 ensembl:ENSRNOP00000072062	F	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K210 ensembl:ENSRNOP00000072062	C	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K210 ensembl:ENSRNOP00000072062	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K210 ensembl:ENSRNOP00000072062	P	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K210 ensembl:ENSRNOP00000072062	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K210 ensembl:ENSRNOP00000072062	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K210 ensembl:ENSRNOP00000072062	C	Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K210 ensembl:ENSRNOP00000072062	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F	Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR016248 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR016248 InterPro:IPR020635	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	P	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	C	Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F	Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:12815063^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05230	F	Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:12815063^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05230	F	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:10918587^[11] Reactome:R-HSA-5654741 Reactome:R-HSA-190372 Reactome:R-HSA-190371	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10918587^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:10918587^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:8601314^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:10918587^[11] Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	PMID:15748888^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:15748888^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035988	chondrocyte proliferation	PMID:15748888^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0005925	focal adhesion	PMID:15748888^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0003416	endochondral bone growth	PMID:15748888^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	PMID:15748888^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001958	endochondral ossification	PMID:15748888^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5654634 Reactome:R-HSA-5654633 Reactome:R-HSA-5654631 Reactome:R-HSA-5654628 Reactome:R-HSA-5654625 Reactome:R-HSA-5654623 Reactome:R-HSA-5654565 Reactome:R-HSA-5654416 Reactome:R-HSA-5654413 Reactome:R-HSA-5654409 Reactome:R-HSA-5654408 Reactome:R-HSA-5654224 Reactome:R-HSA-5654222 Reactome:R-HSA-5654148 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-2077420 Reactome:R-HSA-2038387 Reactome:R-HSA-2038386 Reactome:R-HSA-2033485 Reactome:R-HSA-2033476 Reactome:R-HSA-2012084 Reactome:R-HSA-2012082 Reactome:R-HSA-2012074 Reactome:R-HSA-2012073 Reactome:R-HSA-190388 Reactome:R-HSA-190385 Reactome:R-HSA-190263 Reactome:R-HSA-190261 Reactome:R-HSA-109699 Reactome:R-HSA-8853323 Reactome:R-HSA-8853317 Reactome:R-HSA-8853316 Reactome:R-HSA-8853315 Reactome:R-HSA-8853314 Reactome:R-HSA-8853310 Reactome:R-HSA-8853309 Reactome:R-HSA-8853308 Reactome:R-HSA-8853307 Reactome:R-HSA-5672965 Reactome:R-HSA-5655315 Reactome:R-HSA-5655295 Reactome:R-HSA-5655289 Reactome:R-HSA-5655285 Reactome:R-HSA-5655277 Reactome:R-HSA-5655270 Reactome:R-HSA-5655262 Reactome:R-HSA-5655247 Reactome:R-HSA-5655244 Reactome:R-HSA-5655243 Reactome:R-HSA-5654730 Reactome:R-HSA-5654709 Reactome:R-HSA-5654705 Reactome:R-HSA-5654679 Reactome:R-HSA-5654647 Reactome:R-HSA-5654646 Reactome:R-HSA-5654643 Reactome:R-HSA-5654641 Reactome:R-HSA-5654640 Reactome:R-HSA-5654637	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Su, N et al. (2010) Generation of Fgfr3 conditional knockout mice. Int. J. Biol. Sci. 6 327-32 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Rieckmann, T et al. (2008) The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion. Exp. Cell Res. 314 1071-81 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Harada, D et al. (2007) Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1. Bone 41 273-81 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Hart, KC et al. (2001) Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol. Biol. Cell 12 931-42 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 Ornitz, DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 15292-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Bocharov, EV et al. (2013) Structure of FGFR3 transmembrane domain dimer: implications for signaling and human pathologies. Structure 21 2087-93 PubMed GONUTS page
↑ Huang, Z et al. (2013) Structural mimicry of a-loop tyrosine phosphorylation by a pathogenic FGF receptor 3 mutation. Structure 21 1889-96 PubMed GONUTS page
↑ Olsen, SK et al. (2004) Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc. Natl. Acad. Sci. U.S.A. 101 935-40 PubMed GONUTS page
↑ ^10.0 ^10.1 Olsen, SK et al. (2003) Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J. Biol. Chem. 278 34226-36 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Hart, KC et al. (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene 19 3309-20 PubMed GONUTS page
↑ Deng, C et al. (1996) Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84 911-21 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 L'Hôte, CG & Knowles, MA (2005) Cell responses to FGFR3 signalling: growth, differentiation and apoptosis. Exp. Cell Res. 304 417-31 PubMed GONUTS page

[PMID:20582225-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Su, N et al. (2010) Generation of Fgfr3 conditional knockout mice. Int. J. Biol. Sci. 6 327-32 PubMed GONUTS page

[PMID:18061161-2] 2.0 ^2.1 ^2.2 Rieckmann, T et al. (2008) The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion. Exp. Cell Res. 314 1071-81 PubMed GONUTS page

[PMID:17561467-3] 3.0 ^3.1 ^3.2 Harada, D et al. (2007) Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1. Bone 41 273-81 PubMed GONUTS page

[PMID:11294897-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Hart, KC et al. (2001) Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol. Biol. Cell 12 931-42 PubMed GONUTS page

[PMID:8663044-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 Ornitz, DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 15292-7 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24120763-7] Bocharov, EV et al. (2013) Structure of FGFR3 transmembrane domain dimer: implications for signaling and human pathologies. Structure 21 2087-93 PubMed GONUTS page

[PMID:23972473-8] Huang, Z et al. (2013) Structural mimicry of a-loop tyrosine phosphorylation by a pathogenic FGF receptor 3 mutation. Structure 21 1889-96 PubMed GONUTS page

[PMID:14732692-9] Olsen, SK et al. (2004) Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc. Natl. Acad. Sci. U.S.A. 101 935-40 PubMed GONUTS page

[PMID:12815063-10] 10.0 ^10.1 Olsen, SK et al. (2003) Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J. Biol. Chem. 278 34226-36 PubMed GONUTS page

[PMID:10918587-11] 11.0 ^11.1 ^11.2 ^11.3 Hart, KC et al. (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene 19 3309-20 PubMed GONUTS page

[PMID:8601314-12] Deng, C et al. (1996) Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84 911-21 PubMed GONUTS page

[PMID:15748888-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 L'Hôte, CG & Knowles, MA (2005) Cell responses to FGFR3 signalling: growth, differentiation and apoptosis. Exp. Cell Res. 304 417-31 PubMed GONUTS page

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