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HUMAN:FBLI1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | FBLIM1 (synonyms: FBLP1) | |
| Protein Name(s) | Filamin-binding LIM protein 1
FBLP-1 Migfilin Mitogen-inducible 2-interacting protein MIG2-interacting protein | |
| External Links | ||
| UniProt | Q8WUP2 | |
| EMBL | AY180161 AF459643 AK027444 AK055259 AL450998 AL450998 BC019895 AL133035 | |
| CCDS | CCDS163.1 CCDS30609.1 CCDS44064.1 | |
| PIR | T42678 | |
| RefSeq | NP_001019386.1 NP_001019387.1 NP_060026.2 XP_005245957.1 XP_005245958.1 XP_005245959.1 XP_005245960.1 XP_005245961.1 XP_005245965.1 XP_005245966.1 XP_005245968.1 XP_006710767.1 XP_006710768.1 | |
| UniGene | Hs.530101 | |
| PDB | 2K9U 2W0P | |
| PDBsum | 2K9U 2W0P | |
| ProteinModelPortal | Q8WUP2 | |
| SMR | Q8WUP2 | |
| BioGrid | 120128 | |
| IntAct | Q8WUP2 | |
| STRING | 9606.ENSP00000416387 | |
| PhosphoSite | Q8WUP2 | |
| DMDM | 125987829 | |
| MaxQB | Q8WUP2 | |
| PaxDb | Q8WUP2 | |
| PRIDE | Q8WUP2 | |
| DNASU | 54751 | |
| Ensembl | ENST00000332305 ENST00000375766 ENST00000375771 ENST00000441801 | |
| GeneID | 54751 | |
| KEGG | hsa:54751 | |
| UCSC | uc001axd.1 uc001axg.1 uc001axh.1 | |
| CTD | 54751 | |
| GeneCards | GC01P016083 | |
| HGNC | HGNC:24686 | |
| HPA | HPA025287 | |
| MIM | 607747 | |
| neXtProt | NX_Q8WUP2 | |
| PharmGKB | PA142671776 | |
| eggNOG | NOG315774 | |
| GeneTree | ENSGT00760000119039 | |
| HOGENOM | HOG000007533 | |
| HOVERGEN | HBG051561 | |
| InParanoid | Q8WUP2 | |
| OMA | NRLFCKP | |
| PhylomeDB | Q8WUP2 | |
| TreeFam | TF320310 | |
| Reactome | REACT_20649 | |
| ChiTaRS | FBLIM1 | |
| EvolutionaryTrace | Q8WUP2 | |
| GeneWiki | FBLIM1 | |
| GenomeRNAi | 54751 | |
| NextBio | 57355 | |
| PRO | PR:Q8WUP2 | |
| Proteomes | UP000005640 | |
| Bgee | Q8WUP2 | |
| CleanEx | HS_FBLIM1 | |
| ExpressionAtlas | Q8WUP2 | |
| Genevestigator | Q8WUP2 | |
| GO | GO:0005938 GO:0005829 GO:0005925 GO:0001725 GO:0031005 GO:0008270 GO:0034329 GO:0008360 GO:0033623 GO:0016337 | |
| Gene3D | 2.10.110.10 | |
| InterPro | IPR001781 | |
| Pfam | PF00412 | |
| SMART | SM00132 | |
| PROSITE | PS00478 PS50023 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033623 |
regulation of integrin activation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031005 |
filamin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0034329 |
cell junction assembly |
ECO:0000314 |
P |
Figure 7 shows C-terminals' importance to Migfilin expression. Migfilin or Filamin regulates EGFR's or epidermal growth factor receptors which in turn mediates PLC-y and STAT3-signaling pathways in glioma cells. It is shown that with a greater expression of Migfilin, signal pathways are enhanced and cell junction assembly was amplified. |
complete | |||||
|
involved_in |
GO:0098609 |
cell-cell adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001725 |
stress fiber |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001650 |
fibrillar center |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034329 |
cell junction assembly |
Reactome:R-HSA-446728 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-446364 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0008360 |
regulation of cell shape |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Ithychanda, SS et al. (2009) Migfilin, a molecular switch in regulation of integrin activation. J. Biol. Chem. 284 4713-22 PubMed GONUTS page
- ↑ Ou, Y et al. (2012) Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-γ and STAT3 protein signaling pathways. J. Biol. Chem. 287 32394-405 PubMed GONUTS page
- ↑ Lad, Y et al. (2008) Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. J. Biol. Chem. 283 35154-63 PubMed GONUTS page
