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PMID:22843679
| Citation |
Ou, Y, Ma, L, Dong, L, Ma, L, Zhao, Z, Ma, L, Zhou, W, Fan, J, Wu, C, Yu, C, Zhan, Q and Song, Y (2012) Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-γ and STAT3 protein signaling pathways. J. Biol. Chem. 287:32394-405 |
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| Abstract |
Migfilin is critical for cell shape and motile regulation. However, its pathological role in glioma is unknown. Using an immunohistochemical staining assay, we demonstrate that there is a significant correlation between expression of Migfilin and pathological tumor grade in 217 clinical glioma samples. High Migfilin expression is associated with poor prognosis for patients with glioma. Investigation of the molecular mechanism shows that Migfilin promotes migration and invasion in glioma cells. Moreover, Migfilin positively modulates the expression and activity of epidermal growth factor receptor, and Migfilin-mediated migration and invasion depend on epidermal growth factor receptor-induced PLC-γ and STAT3-signaling pathways. Our results may provide significant clinical application, including use of Migfilin as a molecular marker in glioma for early diagnosis and as an indicator of prognosis. |
| Links |
PubMed PMC3463316 Online version:10.1074/jbc.M112.393900 |
| Keywords |
Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/metabolism; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins/genetics; Cytoskeletal Proteins/metabolism; Gene Expression Regulation, Neoplastic/genetics; Glioma/genetics; Glioma/metabolism; Glioma/pathology; Humans; Neoplasm Invasiveness; Phospholipase C gamma/genetics; Phospholipase C gamma/metabolism; Receptor, Epidermal Growth Factor/biosynthesis; Receptor, Epidermal Growth Factor/genetics; STAT3 Transcription Factor/genetics; STAT3 Transcription Factor/metabolism; Signal Transduction; Tumor Markers, Biological/genetics; Tumor Markers, Biological/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0034329: cell junction assembly |
ECO:0000314: |
P |
Figure 7 shows C-terminals' importance to Migfilin expression. Migfilin or Filamin regulates EGFR's or epidermal growth factor receptors which in turn mediates PLC-y and STAT3-signaling pathways in glioma cells. It is shown that with a greater expression of Migfilin, signal pathways are enhanced and cell junction assembly was amplified. |
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