HUMAN:ERN1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ERN1 (ECO:0000312 with HGNC:HGNC:3449) (synonyms: IRE1 (ECO:0000312 with EMBL:AAC25991.1))
Protein Name(s)	Serine/threonine-protein kinase/endoribonuclease IRE1 Endoplasmic reticulum-to-nucleus signaling 1 Inositol-requiring protein 1 hIRE1p Ire1-alpha IRE1a Serine/threonine-protein kinase Endoribonuclease
External Links
UniProt	O75460
EMBL	AF059198 AK292403 DA254477 AB209869 AC005803 AC025362 CH471109 BC130405 BC130407 BI912495
CCDS	CCDS45762.1
RefSeq	NP_001424.3
UniGene	Hs.133982 Hs.700027 Hs.744953
PDB	2HZ6 3P23 4U6R
PDBsum	2HZ6 3P23 4U6R
ProteinModelPortal	O75460
SMR	O75460
BioGrid	108391
DIP	DIP-31711N
IntAct	O75460
MINT	MINT-3001268
STRING	9606.ENSP00000401445
BindingDB	O75460
ChEMBL	CHEMBL1163101
GuidetoPHARMACOLOGY	2020
PhosphoSite	O75460
MaxQB	O75460
PaxDb	O75460
PRIDE	O75460
DNASU	2081
Ensembl	ENST00000433197 ENST00000606895
GeneID	2081
KEGG	hsa:2081
UCSC	uc002jdz.2
CTD	2081
GeneCards	GC17M062122
H-InvDB	HIX0014084
HGNC	HGNC:3449
HPA	CAB009495 HPA027730
MIM	604033
neXtProt	NX_O75460
PharmGKB	PA27861
eggNOG	COG0515
GeneTree	ENSGT00390000015684
HOGENOM	HOG000012929
HOVERGEN	HBG051506
InParanoid	O75460
KO	K08852
OMA	YVWQREG
OrthoDB	EOG7C2R0H
PhylomeDB	O75460
TreeFam	TF313986
Reactome	REACT_18368
SignaLink	O75460
ChiTaRS	ERN1
EvolutionaryTrace	O75460
GeneWiki	ERN1
GenomeRNAi	2081
NextBio	8459
PRO	PR:O75460
Proteomes	UP000005640
Bgee	O75460
CleanEx	HS_ERN1
Genevestigator	O75460
GO	GO:0005737 GO:0005789 GO:0030176 GO:0005739 GO:0005637 GO:0005524 GO:0004521 GO:0019899 GO:0042802 GO:0000287 GO:0004674 GO:0006987 GO:0007050 GO:0044267 GO:0030968 GO:0070055 GO:0070059 GO:0070054 GO:1900103 GO:0033120 GO:0046777 GO:0006468 GO:0006355 GO:0090502 GO:0006351
Gene3D	2.140.10.10
InterPro	IPR010513 IPR011009 IPR018391 IPR000719 IPR006567 IPR027295 IPR011047 IPR008271
Pfam	PF00069 PF06479
SMART	SM00564 SM00580
SUPFAM	SSF50998 SSF56112
PROSITE	PS51392 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0036498	IRE1-mediated unfolded protein response	PMID:29198525^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:29198525^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQY0	F		Seeded From UniProt	complete
involved_in	GO:0006379	mRNA cleavage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQY0	P		Seeded From UniProt	complete
involved_in	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	PMID:21317875^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	PMID:19328063^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	PMID:20625543^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	PMID:26315405^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	PMID:26315405^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09619	F		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:12446770^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	PMID:20625543^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P17861)	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:10650002^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	PMID:10650002^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0034976)	Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:9637683^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P17861)	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:9637683^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	PMID:23000344^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0036289	peptidyl-serine autophosphorylation	PMID:20103773^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0071333)	Seeded From UniProt	complete
involved_in	GO:0098787	mRNA cleavage involved in mRNA processing	PMID:21317875^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P17861) part_of:(GO:0070054)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:23529610^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	PMID:23529610^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:23529610^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	PMID:21317875^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:P17861) part_of:(GO:0034620)	Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:21317875^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P17861) part_of:(GO:0070054)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21317875^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:O75460) causally_upstream_of:(GO:0004521)	Seeded From UniProt	complete
enables	GO:0043531	ADP binding	PMID:21317875^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:18420)	Seeded From UniProt	complete
involved_in	GO:1990579	peptidyl-serine trans-autophosphorylation	PMID:21317875^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	directly_positively_regulates:(GO:0004521)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21317875^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	causally_upstream_of:(GO:1990579) causally_upstream_of:(GO:0006379)	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:19328063^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990332	Ire1 complex	PMID:19328063^[3]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	PMID:19328063^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:19328063^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P17861) part_of:(GO:0034620)	Seeded From UniProt	complete
involved_in	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	PMID:19328063^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P17861) part_of:(GO:0034620)	Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	PMID:11779464^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	PMID:19622636^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	PMID:19622636^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19622636^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	PMID:11779464^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	PMID:20625543^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DMV8	F		Seeded From UniProt	complete
part_of	GO:1990630	IRE1-RACK1-PP2A complex	PMID:20103773^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901142	insulin metabolic process	PMID:20103773^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0071333)	Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:20103773^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23103912^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8N5Y8	F		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	PMID:11779465^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:11779465^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	PMID:16645094^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	PMID:9637683^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQY0	P		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	PMID:9637683^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9637683^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:9637683^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9637683^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:9637683^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:9637683^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349436 PANTHER:PTN000359335 UniProtKB:O75460	C		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349436 MGI:MGI:1930134 PANTHER:PTN000359335	P		Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000359335 SGD:S000001121	F		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261984 MGI:MGI:1930134 PANTHER:PTN000359335 PomBase:SPAC167.01 UniProtKB:O75460	P		Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261984 MGI:MGI:1930134 PANTHER:PTN000359335 PomBase:SPAC167.01 SGD:S000001121 TAIR:locus:2053928 UniProtKB:O75460 UniProtKB:Q4WKP8 UniProtKB:Q93VJ2 WB:WBGene00002147	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349436 MGI:MGI:1930134 PANTHER:PTN000359335 SGD:S000001121 TAIR:locus:2053928 UniProtKB:O75460 UniProtKB:Q7XIT1	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930134 PANTHER:PTN000359335 SGD:S000001121 UniProtKB:O75460 UniProtKB:Q76MJ5	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930134 PANTHER:PTN000359335 SGD:S000001121 UniProtKB:O75460 UniProtKB:Q76MJ5	F		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261984 MGI:MGI:1930134 PANTHER:PTN000359335 PomBase:SPAC167.01 SGD:S000001121 TAIR:locus:2053928 UniProtKB:O75460 UniProtKB:Q4WKP8 UniProtKB:Q93VJ2	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21317875^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:12637535^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
part_of	GO:1990597	AIP1-IRE1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	C		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	F		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	P		Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	P		Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	P		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	P		Seeded From UniProt	complete
involved_in	GO:0006379	mRNA cleavage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	F		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	F		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQY0 ensembl:ENSMUSP00000001059	F		Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010513	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010513	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20798350^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75460-1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16973740^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75460-1	F		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	PMID:22013210^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006402	mRNA catabolic process	PMID:22013210^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	PMID:22013210^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_direct_input:(UniProtKB:P17861) part_of:(GO:0034620)	Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	Reactome:R-HSA-381070	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-425923 Reactome:R-HSA-381217 Reactome:R-HSA-381109 Reactome:R-HSA-381091	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0834	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Amin-Wetzel, N et al. (2017) A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response. Cell 171 1625-1637.e13 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Ali, MM et al. (2011) Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J. 30 894-905 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Lisbona, F et al. (2009) BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol. Cell 33 679-91 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Gupta, S et al. (2010) HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction. PLoS Biol. 8 e1000410 PubMed GONUTS page
↑ ^5.0 ^5.1 Zeng, L et al. (2015) XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Arterioscler. Thromb. Vasc. Biol. 35 2134-44 PubMed GONUTS page
↑ Marcu, MG et al. (2002) Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Mol. Cell. Biol. 22 8506-13 PubMed GONUTS page
↑ ^7.0 ^7.1 Urano, F et al. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287 664-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 Tirasophon, W et al. (1998) A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12 1812-24 PubMed GONUTS page
↑ Zheng, QY et al. (2013) Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. Cell. Signal. 25 206-13 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Qiu, Y et al. (2010) A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal 3 ra7 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Zeng, L et al. (2013) Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation 127 1712-22 PubMed GONUTS page
↑ ^12.0 ^12.1 Yoshida, H et al. (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107 881-91 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Uemura, A et al. (2009) Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response. J. Cell. Sci. 122 2877-86 PubMed GONUTS page
↑ Jwa, M & Chang, P (2012) PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response. Nat. Cell Biol. 14 1223-30 PubMed GONUTS page
↑ ^15.0 ^15.1 Shen, X et al. (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107 893-903 PubMed GONUTS page
↑ Hetz, C et al. (2006) Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312 572-6 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Liu, CY et al. (2003) Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. J. Biol. Chem. 278 17680-7 PubMed GONUTS page
↑ Li, H et al. (2010) Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc. Natl. Acad. Sci. U.S.A. 107 16113-8 PubMed GONUTS page
↑ Zhou, J et al. (2006) The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc. Natl. Acad. Sci. U.S.A. 103 14343-8 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page

[PMID:29198525-1] 1.0 ^1.1 Amin-Wetzel, N et al. (2017) A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response. Cell 171 1625-1637.e13 PubMed GONUTS page

[PMID:21317875-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Ali, MM et al. (2011) Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J. 30 894-905 PubMed GONUTS page

[PMID:19328063-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Lisbona, F et al. (2009) BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol. Cell 33 679-91 PubMed GONUTS page

[PMID:20625543-4] 4.0 ^4.1 ^4.2 Gupta, S et al. (2010) HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction. PLoS Biol. 8 e1000410 PubMed GONUTS page

[PMID:26315405-5] 5.0 ^5.1 Zeng, L et al. (2015) XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Arterioscler. Thromb. Vasc. Biol. 35 2134-44 PubMed GONUTS page

[PMID:12446770-6] Marcu, MG et al. (2002) Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Mol. Cell. Biol. 22 8506-13 PubMed GONUTS page

[PMID:10650002-7] 7.0 ^7.1 Urano, F et al. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287 664-6 PubMed GONUTS page

[PMID:9637683-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 Tirasophon, W et al. (1998) A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12 1812-24 PubMed GONUTS page

[PMID:23000344-9] Zheng, QY et al. (2013) Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. Cell. Signal. 25 206-13 PubMed GONUTS page

[PMID:20103773-10] 10.0 ^10.1 ^10.2 ^10.3 Qiu, Y et al. (2010) A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal 3 ra7 PubMed GONUTS page

[PMID:23529610-11] 11.0 ^11.1 ^11.2 Zeng, L et al. (2013) Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation 127 1712-22 PubMed GONUTS page

[PMID:11779464-12] 12.0 ^12.1 Yoshida, H et al. (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107 881-91 PubMed GONUTS page

[PMID:19622636-13] 13.0 ^13.1 ^13.2 Uemura, A et al. (2009) Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response. J. Cell. Sci. 122 2877-86 PubMed GONUTS page

[PMID:23103912-14] Jwa, M & Chang, P (2012) PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response. Nat. Cell Biol. 14 1223-30 PubMed GONUTS page

[PMID:11779465-15] 15.0 ^15.1 Shen, X et al. (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107 893-903 PubMed GONUTS page

[PMID:16645094-16] Hetz, C et al. (2006) Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312 572-6 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12637535-18] Liu, CY et al. (2003) Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. J. Biol. Chem. 278 17680-7 PubMed GONUTS page

[PMID:20798350-19] Li, H et al. (2010) Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc. Natl. Acad. Sci. U.S.A. 107 16113-8 PubMed GONUTS page

[PMID:16973740-20] Zhou, J et al. (2006) The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc. Natl. Acad. Sci. U.S.A. 103 14343-8 PubMed GONUTS page

[PMID:22013210-21] 21.0 ^21.1 ^21.2 Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page

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