PMID:11779465

Citation	Shen, X, Ellis, RE, Lee, K, Liu, CY, Yang, K, Solomon, A, Yoshida, H, Morimoto, R, Kurnit, DM, Mori, K and Kaufman, RJ (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107:893-903
Abstract	The unfolded protein response (UPR) is a transcriptional and translational intracellular signaling pathway activated by the accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER). We have used C. elegans as a genetic model system to dissect UPR signaling in a multicellular organism. C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress. In addition, ire-1/xbp-1 acts with pek-1, a protein kinase that mediates translation attenuation, in complementary pathways that are essential for worm development and survival. We propose that UPR transcriptional activation by ire-1 as well as translational attenuation by pek-1 maintain ER homeostasis. The results demonstrate that the UPR and ER homeostasis are essential for metazoan development.
Links	PubMed
Keywords	Animals; Caenorhabditis elegans/embryology; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins; Cell Cycle Proteins; Fungal Proteins/genetics; MAP Kinase Kinase 1; Membrane Glycoproteins/genetics; Mitogen-Activated Protein Kinase Kinases/genetics; Molecular Sequence Data; Mutation; Protein Folding; Protein-Serine-Threonine Kinases; Repressor Proteins/genetics; Saccharomyces cerevisiae Proteins; Signal Transduction; Transcription Factors/genetics; Transcriptional Activation/physiology
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