HUMAN:DYN2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DNM2 (synonyms: DYN2)
Protein Name(s)	Dynamin-2
External Links
UniProt	P50570
EMBL	L36983 AK289831 AK312260 AC007229 AC011475 AC011552 AC011554 AC112707 BC039596 BC054501
CCDS	CCDS32907.1 CCDS32908.1 CCDS45968.1 CCDS45969.1 CCDS59351.1
PIR	JC4305
RefSeq	NP_001005360.1 NP_001005361.1 NP_001005362.1 NP_001177645.1 NP_004936.2
UniGene	Hs.211463
PDB	2YS1
PDBsum	2YS1
ProteinModelPortal	P50570
SMR	P50570
BioGrid	108122
DIP	DIP-31244N
IntAct	P50570
MINT	MINT-5004324
STRING	9606.ENSP00000352721
BindingDB	P50570
ChEMBL	CHEMBL5812
PhosphoSite	P50570
DMDM	47117856
MaxQB	P50570
PaxDb	P50570
PRIDE	P50570
Ensembl	ENST00000355667 ENST00000359692 ENST00000389253 ENST00000408974 ENST00000585892
GeneID	1785
KEGG	hsa:1785
UCSC	uc002mpt.2 uc002mpu.2 uc002mpv.2
CTD	1785
GeneCards	GC19P010824
GeneReviews	DNM2
HGNC	HGNC:2974
HPA	HPA054246
MIM	160150 602378 606482 615368
neXtProt	NX_P50570
Orphanet	169189 228179 100044 363409
PharmGKB	PA27442
eggNOG	COG0699
GeneTree	ENSGT00760000119213
HOGENOM	HOG000161069
HOVERGEN	HBG107833
InParanoid	P50570
KO	K01528
OrthoDB	EOG76MK7N
PhylomeDB	P50570
TreeFam	TF300362
Reactome	REACT_11035 REACT_11049 REACT_121399 REACT_12435 REACT_12541 REACT_19287 REACT_19400 REACT_22365 REACT_6894
SignaLink	P50570
ChiTaRS	DNM2
EvolutionaryTrace	P50570
GeneWiki	DNM2
GenomeRNAi	1785
NextBio	7257
PRO	PR:P50570
Proteomes	UP000005640
Bgee	P50570
CleanEx	HS_DNM2
ExpressionAtlas	P50570
Genevestigator	P50570
GO	GO:0005737 GO:0005829 GO:0030666 GO:0070062 GO:0005925 GO:0005794 GO:0000139 GO:0005874 GO:0030496 GO:0005886 GO:0014069 GO:0045211 GO:0019899 GO:0005525 GO:0003924 GO:0008017 GO:0017124 GO:0019886 GO:0006897 GO:0000086 GO:0006184 GO:0061024 GO:1903526 GO:0046209 GO:0043065 GO:0045893 GO:0006892 GO:0031623 GO:0050999 GO:0006355 GO:0007165 GO:0044281 GO:0048489 GO:0033572
Gene3D	2.30.29.30 3.40.50.300
InterPro	IPR027188 IPR000375 IPR001401 IPR019762 IPR022812 IPR030381 IPR003130 IPR020850 IPR027417 IPR001849 IPR011993
PANTHER	PTHR11566 PTHR11566:SF23
Pfam	PF01031 PF02212 PF00169
PRINTS	PR00195
SMART	SM00053 SM00302 SM00233
SUPFAM	SSF52540
PROSITE	PS00410 PS51718 PS51388 PS50003

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
colocalizes_with	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39052	C		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39052	C		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39052	P		Seeded From UniProt	complete
involved_in	GO:0030516	regulation of axon extension	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39052	P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39052	P		Seeded From UniProt	complete
involved_in	GO:1903526	negative regulation of membrane tubulation	PMID:18388313^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18388313^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0000086	G2/M transition of mitotic cell cycle	PMID:28131267^[2]	ECO:0000314			P		Microtubule production, also involved in cytokinesis and endocytosis.	complete CACAO 12824
enables	GO:0017124	SH3 domain binding	PMID:18388313^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0033572	transferrin transport	PMID:14985334^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:14985334^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	PMID:11583995^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10893263^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:11583995^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:10893263^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11583995^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:7590285^[9]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10893263^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:10101292^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:11583995^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:10893263^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21525035^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:7590285^[9]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:11583995^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	PMID:7590285^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098884	postsynaptic neurotransmitter receptor internalization	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170172 RGD:727949	P		Seeded From UniProt	complete
part_of	GO:0098844	postsynaptic endocytic zone membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170172 RGD:727949	C		Seeded From UniProt	complete
involved_in	GO:0050803	regulation of synapse structure or activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 PANTHER:PTN000170172	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170172 UniProtKB:P50570	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 PANTHER:PTN000170172 RGD:71096 RGD:727949 WB:WBGene00001130	C		Seeded From UniProt	complete
part_of	GO:0044327	dendritic spine head	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170172 RGD:727949	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170172 RGD:727949	C		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000902093 RGD:71096 UniProtKB:P50570	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000902092 WB:WBGene00001130	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170172 RGD:727949 WB:WBGene00001130	C		Seeded From UniProt	complete
involved_in	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 MGI:MGI:107384 MGI:MGI:1341299 PANTHER:PTN000902093	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170013 TAIR:locus:2006777 TAIR:locus:2012763 UniProtKB:Q8S944	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170172 RGD:727949	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 PANTHER:PTN000170013	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 PANTHER:PTN000902092 RGD:2513 RGD:71096	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 MGI:MGI:1921256 PANTHER:PTN000170013 PomBase:SPBC12C2.08 RGD:2513 RGD:628821 RGD:71096 RGD:727949 TAIR:locus:2006777 UniProtKB:K7GKN2 UniProtKB:O00429 UniProtKB:P20591 UniProtKB:P27594 UniProtKB:P79135 UniProtKB:Q8IHR4 dictyBase:DDB_G0277849 dictyBase:DDB_G0277851	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170013 RGD:2513 RGD:727949 SGD:S000001709 SGD:S000003924 UniProtKB:K7GKN2 UniProtKB:O00429 UniProtKB:O60313 UniProtKB:P27594 UniProtKB:P42697 UniProtKB:Q8S944 WB:WBGene00001130 dictyBase:DDB_G0277849	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0048488	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016185	C		Seeded From UniProt	complete
involved_in	GO:2000370	positive regulation of clathrin-dependent endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:1903408	positive regulation of sodium:potassium-exchanging ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:1903358	regulation of Golgi organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:1902856	negative regulation of non-motile cilium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
involved_in	GO:0071732	cellular response to nitric oxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:0071481	cellular response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:0071245	cellular response to carbon monoxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	F		Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	F		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
involved_in	GO:0045807	positive regulation of endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
part_of	GO:0045334	clathrin-coated endocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	F		Seeded From UniProt	complete
involved_in	GO:0044351	macropinocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
enables	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	F		Seeded From UniProt	complete
involved_in	GO:0035020	regulation of Rac protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
enables	GO:0031749	D2 dopamine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	F		Seeded From UniProt	complete
involved_in	GO:0030516	regulation of axon extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	F		Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:0009416	response to light stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
involved_in	GO:0006893	Golgi to plasma membrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	F		Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	P		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39052 ensembl:ENSRNOP00000010948	C		Seeded From UniProt	complete
involved_in	GO:0060976	coronary vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39054 ensembl:ENSMUSP00000133564	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39054 ensembl:ENSMUSP00000133564	P		Seeded From UniProt	complete
involved_in	GO:0035904	aorta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39054 ensembl:ENSMUSP00000133564	P		Seeded From UniProt	complete
involved_in	GO:0003281	ventricular septum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39054 ensembl:ENSMUSP00000133564	P		Seeded From UniProt	complete
part_of	GO:0001917	photoreceptor inner segment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39054 ensembl:ENSMUSP00000133564	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001401 InterPro:IPR003130 InterPro:IPR027188	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000375 InterPro:IPR001401 InterPro:IPR003130 InterPro:IPR030381	F		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027188	C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027188	P		Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050999	regulation of nitric-oxide synthase activity	Reactome:R-HSA-203641	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-203625	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Reactome:R-HSA-2132295	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-203662 Reactome:R-HSA-203625 Reactome:R-HSA-203565	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8951498 Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-432707 Reactome:R-HSA-432706 Reactome:R-HSA-421835 Reactome:R-HSA-421831 Reactome:R-HSA-2130641 Reactome:R-HSA-2130619	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	Reactome:R-HSA-8868661 Reactome:R-HSA-432707 Reactome:R-HSA-421835	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-432707 Reactome:R-HSA-432706 Reactome:R-HSA-421835 Reactome:R-HSA-421831	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0581	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0469	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
part_of	GO:0030670	phagocytic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0205	C		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0473	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Shin, N et al. (2008) SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2. J. Cell. Sci. 121 1252-63 PubMed GONUTS page
↑ Trochet, D et al. (2016) Reprogramming the Dynamin 2 mRNA by Spliceosome-mediated RNA Trans-splicing. Mol Ther Nucleic Acids 5 e362 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^6.0 ^6.1 Huang, F et al. (2004) Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J. Biol. Chem. 279 16657-61 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Okamoto, PM et al. (2001) Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton. J. Biol. Chem. 276 48458-65 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Fish, KN et al. (2000) Evidence that dynamin-2 functions as a signal-transducing GTPase. J. Cell Biol. 150 145-54 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Diatloff-Zito, C et al. (1995) Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family. Gene 163 301-6 PubMed GONUTS page
↑ Kasai, K et al. (1999) Dynamin II is involved in endocytosis but not in the formation of transport vesicles from the trans-Golgi network. J. Biochem. 125 780-9 PubMed GONUTS page
↑ Bharti, P et al. (2011) PEX14 is required for microtubule-based peroxisome motility in human cells. J. Cell. Sci. 124 1759-68 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18388313-1] 1.0 ^1.1 ^1.2 Shin, N et al. (2008) SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2. J. Cell. Sci. 121 1252-63 PubMed GONUTS page

[PMID:28131267-2] Trochet, D et al. (2016) Reprogramming the Dynamin 2 mRNA by Spliceosome-mediated RNA Trans-splicing. Mol Ther Nucleic Acids 5 e362 PubMed GONUTS page

[PMID:21423176-3] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:23533145-4] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-5] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:14985334-6] 6.0 ^6.1 Huang, F et al. (2004) Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J. Biol. Chem. 279 16657-61 PubMed GONUTS page

[PMID:11583995-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Okamoto, PM et al. (2001) Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton. J. Biol. Chem. 276 48458-65 PubMed GONUTS page

[PMID:10893263-8] 8.0 ^8.1 ^8.2 ^8.3 Fish, KN et al. (2000) Evidence that dynamin-2 functions as a signal-transducing GTPase. J. Cell Biol. 150 145-54 PubMed GONUTS page

[PMID:7590285-9] 9.0 ^9.1 ^9.2 Diatloff-Zito, C et al. (1995) Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family. Gene 163 301-6 PubMed GONUTS page

[PMID:10101292-10] Kasai, K et al. (1999) Dynamin II is involved in endocytosis but not in the formation of transport vesicles from the trans-Golgi network. J. Biochem. 125 780-9 PubMed GONUTS page

[PMID:21525035-11] Bharti, P et al. (2011) PEX14 is required for microtubule-based peroxisome motility in human cells. J. Cell. Sci. 124 1759-68 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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