GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:DACH1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DACH1 (synonyms: DACH) | |
| Protein Name(s) | Dachshund homolog 1
Dach1 | |
| External Links | ||
| UniProt | Q9UI36 | |
| EMBL | AF102546 AF069509 AF356492 AL138698 AL139186 AL163542 AL354995 AL138698 AL139186 AL163542 AL354995 AL139186 AL138698 AL163542 AL354995 AL139186 AL138698 AL163542 AL354995 AL163542 AL138698 AL139186 AL354995 AL163542 AL138698 AL139186 AL354995 AL354995 AL138698 AL139186 AL163542 AL354995 AL138698 AL139186 AL163542 CH471093 CH471093 AL079278 AJ005670 BC021219 | |
| RefSeq | NP_004383.4 NP_542937.3 NP_542938.3 | |
| UniGene | Hs.129452 | |
| PDB | 1L8R | |
| PDBsum | 1L8R | |
| ProteinModelPortal | Q9UI36 | |
| SMR | Q9UI36 | |
| BioGrid | 107972 | |
| IntAct | Q9UI36 | |
| PhosphoSite | Q9UI36 | |
| DMDM | 519668677 | |
| MaxQB | Q9UI36 | |
| PaxDb | Q9UI36 | |
| PRIDE | Q9UI36 | |
| DNASU | 1602 | |
| Ensembl | ENST00000613252 | |
| GeneID | 1602 | |
| KEGG | hsa:1602 | |
| UCSC | uc021rkj.1 uc021rkk.1 uc021rkl.1 | |
| CTD | 1602 | |
| GeneCards | GC13M072012 | |
| H-InvDB | HIX0025348 | |
| HGNC | HGNC:2663 | |
| HPA | HPA012672 | |
| MIM | 603803 | |
| neXtProt | NX_Q9UI36 | |
| PharmGKB | PA27134 | |
| eggNOG | NOG279124 | |
| GeneTree | ENSGT00390000001134 | |
| HOVERGEN | HBG065810 | |
| InParanoid | Q9UI36 | |
| OMA | HPRMPGA | |
| OrthoDB | EOG7ZKSCN | |
| TreeFam | TF316697 | |
| ChiTaRS | DACH1 | |
| EvolutionaryTrace | Q9UI36 | |
| GeneWiki | DACH1 | |
| GenomeRNAi | 1602 | |
| NextBio | 6570 | |
| PRO | PR:Q9UI36 | |
| Proteomes | UP000005640 | |
| Bgee | Q9UI36 | |
| Genevestigator | Q9UI36 | |
| GO | GO:0005634 GO:0003677 GO:0001078 GO:0007275 GO:0030336 GO:0010944 GO:0000122 | |
| Gene3D | 3.10.260.20 | |
| InterPro | IPR009061 IPR003380 | |
| Pfam | PF02437 | |
| SUPFAM | SSF46955 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
ECO:0000315 |
P |
Figure 4. shows Ectopic DACH1 expression decreases FGF2 expression, spheroid formation, and tumor growth. |
complete | |||||
| GO:0048147 |
negative regulation of fibroblast proliferation |
ECO:0000315 |
P |
Figure 1 shows induction of DACH1 represses colony formation and tumor growth. |
complete | |||||
| GO:2000279 |
negative regulation of DNA biosynthetic process |
ECO:0000314 |
P |
figure 2 shows dna synthesis inhibition through the DS domain of DACH1 |
complete | |||||
|
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000279 |
negative regulation of DNA biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010944 |
negative regulation of transcription by competitive promoter binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277991 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277991 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0005677 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060244 |
negative regulation of cell proliferation involved in contact inhibition |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048147 |
negative regulation of fibroblast proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046545 |
development of primary female sexual characteristics |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033262 |
regulation of nuclear cell cycle DNA replication |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007585 |
respiratory gaseous exchange |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001967 |
suckling behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QYB2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Watanabe, A et al. (2011) Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells. Proc. Natl. Acad. Sci. U.S.A. 108 12384-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Wu, K et al. (2006) DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth. Mol. Cell. Biol. 26 7116-29 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Zhou, J et al. (2010) Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1. J. Biol. Chem. 285 40342-50 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
d
- GO:0046545 ! development of primary female sexual characteristics
- GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0003700 ! DNA-binding transcription factor activity
- GO:0001227 ! DNA-binding transcription repressor activity, RNA polymerase II-specific
- GO:0003677 ! DNA binding
n
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0048147 ! negative regulation of fibroblast proliferation
- GO:0060244 ! negative regulation of cell proliferation involved in contact inhibition
- GO:0030336 ! negative regulation of cell migration
- GO:0010944 ! negative regulation of transcription by competitive promoter binding
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:2000279 ! negative regulation of DNA biosynthetic process
- GO:0005634 ! nucleus
p
r
- GO:0033262 ! regulation of nuclear cell cycle DNA replication
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0007585 ! respiratory gaseous exchange by respiratory system
- GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding
