HUMAN:CXL10

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CXCL10 (synonyms: INP10, SCYB10)
Protein Name(s)	C-X-C motif chemokine 10 10 kDa interferon gamma-induced protein Gamma-IP10 IP-10 Small-inducible cytokine B10 CXCL10(1-73)
External Links
UniProt	P02778
EMBL	X02530 BC010954
CCDS	CCDS43240.1
PIR	A03243
RefSeq	NP_001556.2
UniGene	Hs.632586
PDB	1LV9 1O7Y 1O7Z 1O80
PDBsum	1LV9 1O7Y 1O7Z 1O80
ProteinModelPortal	P02778
SMR	P02778
BioGrid	109839
DIP	DIP-5893N
IntAct	P02778
MINT	MINT-91448
STRING	9606.ENSP00000305651
PhosphoSite	P02778
DMDM	21542456
MaxQB	P02778
PaxDb	P02778
PRIDE	P02778
DNASU	3627
Ensembl	ENST00000306602
GeneID	3627
KEGG	hsa:3627
UCSC	uc003hjl.4
CTD	3627
GeneCards	GC04M076942
HGNC	HGNC:10637
MIM	147310
neXtProt	NX_P02778
PharmGKB	PA35568
eggNOG	NOG47968
GeneTree	ENSGT00530000063958
HOGENOM	HOG000220915
HOVERGEN	HBG107789
InParanoid	P02778
KO	K12671
OMA	RCTCIKI
OrthoDB	EOG7HHWVH
PhylomeDB	P02778
TreeFam	TF333433
Reactome	REACT_15344 REACT_19231
EvolutionaryTrace	P02778
GeneWiki	CXCL10
GenomeRNAi	3627
NextBio	14193
PRO	PR:P02778
Proteomes	UP000005640
Bgee	P02778
CleanEx	HS_CXCL10
ExpressionAtlas	P02778
Genevestigator	P02778
GO	GO:0009897 GO:0005576 GO:0005615 GO:0008603 GO:0008009 GO:0048248 GO:0008201 GO:0005102 GO:0008015 GO:0007166 GO:0007267 GO:0034605 GO:0071222 GO:0070098 GO:0006935 GO:0051607 GO:0007186 GO:0006955 GO:0006954 GO:0007517 GO:0016525 GO:0030816 GO:0043950 GO:0008284 GO:0002690 GO:0051281 GO:2000406 GO:0045944 GO:0009306 GO:0042127 GO:0045859 GO:0010996 GO:0009409 GO:0010332 GO:0033280 GO:0007165 GO:0010818
InterPro	IPR001089 IPR018048 IPR027220 IPR001811
PANTHER	PTHR10179 PTHR10179:SF5
Pfam	PF00048
PRINTS	PR00437
SMART	SM00199
SUPFAM	SSF54117
PROSITE	PS00471

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:1901509	regulation of endothelial tube morphogenesis	PMID:16484616^[1]	ECO:0000314			P	Fig 1A/1B shows that when incubated with CXCL10, human adult dermal microvascular cells do not form as many of the tubes needed for angiogenesis as the control group without CXCL10 does.	complete CACAO 5329
	GO:0010596	negative regulation of endothelial cell migration	PMID:16484616^[1]	ECO:0000314			P	Fig 2A shows a significant drop in the migration of the HMEC-1 cells in the presence of CXCL10.	complete CACAO 5335
	GO:0010819	regulation of T cell chemotaxis	PMID:8608232^[2]	ECO:0000314			P	Figure 1A shows that addition of the chemokine rhIP-10 regulates the movement of the T-cells in vitro.	complete CACAO 5482
	GO:0090026	positive regulation of monocyte chemotaxis	PMID:8608232^[2]	ECO:0000314			P	Figure 1B shows that the addition of the chemokine rhIP-10 leads to increased monocyte chemotaxis.	complete CACAO 5483
	GO:0010596	negative regulation of endothelial cell migration	PMID:16484616^[1]	ECO:0000314			P	Fig 2A shows a significant drop in the migration of the HMEC-1 cells in the presence of CXCL10.	complete
	GO:0090026	positive regulation of monocyte chemotaxis	PMID:8608232^[2][	ECO:0000314			P	Figure 1B shows increased monocyte chemotaxis in response to IP10	complete CACAO 5660
	GO:0010596	negative regulation of endothelial cell migration	PMID:16484616^[1]	ECO:0000314			P	Fig 2A shows a significant drop in the migration of the HMEC-1 cells in the presence of CXCL10.	complete
	GO:0042118	endothelial cell activation	PMID:19470579^[3]	ECO:0000316		UniProtKB:P49682	P	Figures 3A and 3B show that IP-10 is causing the endothelial cells to dissociate. Figure 5 shows that when an anti-CXCR3 antibody is introduced, IP-10 does not lead to cell dissociation.	complete CACAO 6057
involved_in	GO:0042981	regulation of apoptotic process	PMID:22652417^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:11157474^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:7540647^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901509	regulation of endothelial tube morphogenesis	PMID:16484616^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042118	endothelial cell activation	PMID:19470579^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49682	P	Seeded From UniProt	complete
involved_in	GO:0090026	positive regulation of monocyte chemotaxis	PMID:8608232^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010819	regulation of T cell chemotaxis	PMID:8608232^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	PMID:18645041^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010818	T cell chemotaxis	PMID:18645041^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:18645041^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:20041150^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	PMID:12782716^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048248	CXCR3 chemokine receptor binding	PMID:12782716^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:12782716^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:12782716^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	PMID:12782716^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:12782716^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:12782716^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 RGD:621812 RGD:70069 RGD:708540 UniProtKB:P02778 UniProtKB:P10145 UniProtKB:P80162 UniProtKB:P80221	P	Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 UniProtKB:O14625 UniProtKB:P02778	P	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1888711 PANTHER:PTN000021269 UniProtKB:P02776 UniProtKB:P80162 UniProtKB:P80221	P	Seeded From UniProt	complete
involved_in	GO:0030595	leukocyte chemotaxis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 RGD:70069 UniProtKB:P02776	P	Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339941 MGI:MGI:3037818 PANTHER:PTN000021269 RGD:619869 RGD:621812 RGD:70069 UniProtKB:P10145 UniProtKB:P79255 UniProtKB:P80162 UniProtKB:P80221	P	Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339941 MGI:MGI:1888499 MGI:MGI:1888712 MGI:MGI:3037818 PANTHER:PTN000021269 RGD:619869 RGD:620209 RGD:621812 RGD:70069 RGD:708540 RGD:727827 UniProtKB:O14625 UniProtKB:O43927 UniProtKB:P02778 UniProtKB:P10145 UniProtKB:P80162 UniProtKB:P80221 UniProtKB:Q07325	F	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 RGD:3305 RGD:620209 RGD:727827	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339941 PANTHER:PTN000021269 RGD:621812 RGD:708540	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108068 MGI:MGI:1340094 MGI:MGI:1352449 MGI:MGI:1352450 MGI:MGI:1888499 PANTHER:PTN000021269 RGD:619869 RGD:620209 RGD:621812 RGD:70069 RGD:708540 UniProtKB:P19876	C	Seeded From UniProt	complete
involved_in	GO:2000406	positive regulation of T cell migration	PMID:23620790^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:23776175^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0045859	regulation of protein kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008603	P	Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P	Seeded From UniProt	complete
involved_in	GO:1901740	negative regulation of myoblast fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17515 ensembl:ENSMUSP00000047646	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17515 ensembl:ENSMUSP00000047646	P	Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17515 ensembl:ENSMUSP00000047646	P	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17515 ensembl:ENSMUSP00000047646	C	Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17515 ensembl:ENSMUSP00000047646	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17515 ensembl:ENSMUSP00000047646	C	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
involved_in	GO:0033280	response to vitamin D	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
involved_in	GO:0010996	response to auditory stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	F	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	C	Seeded From UniProt	complete
involved_in	GO:0002690	positive regulation of leukocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48973 ensembl:ENSRNOP00000003649	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR036048	C	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033899	P	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033899	P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR036048	P	Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR033899 InterPro:IPR036048	F	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:12949249^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:12949249^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:12949249^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008603	cAMP-dependent protein kinase regulator activity	PMID:10903763^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8798675^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008015	blood circulation	PMID:8798675^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	PMID:10903763^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007517	muscle organ development	PMID:8798675^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:3925348^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:10903763^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10201891^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:10903763^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:10903763^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:10201891^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12782716^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6783783	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-6784160 Reactome:R-HSA-380073 Reactome:R-HSA-374248	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Bodnar, RJ et al. (2006) IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circ. Res. 98 617-25 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Taub, DD et al. (1996) Human interferon-inducible protein-10 induces mononuclear cell infiltration in mice and promotes the migration of human T lymphocytes into the peripheral tissues and human peripheral blood lymphocytes-SCID mice. Blood 87 1423-31 PubMed GONUTS page
↑ ^3.0 ^3.1 Bodnar, RJ et al. (2009) IP-10 induces dissociation of newly formed blood vessels. J. Cell. Sci. 122 2064-77 PubMed GONUTS page
↑ Sidahmed, AM et al. (2012) CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro. Cytokine 59 433-41 PubMed GONUTS page
↑ Romagnani, P et al. (2001) Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus. Blood 97 601-7 PubMed GONUTS page
↑ Angiolillo, AL et al. (1995) Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J. Exp. Med. 182 155-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Loos, T et al. (2008) Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood 112 2648-56 PubMed GONUTS page
↑ Feng, J et al. (2009) Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. PLoS ONE 4 e8480 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Lasagni, L et al. (2003) An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J. Exp. Med. 197 1537-49 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Chiang, YJ et al. (2013) CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE 8 e61761 PubMed GONUTS page
↑ Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Yang, D et al. (2003) Many chemokines including CCL20/MIP-3alpha display antimicrobial activity. J. Leukoc. Biol. 74 448-55 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Jinquan, T et al. (2000) CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma. J. Immunol. 165 1548-56 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Wang, X et al. (1996) Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response. J. Biol. Chem. 271 24286-93 PubMed GONUTS page
↑ Luster, AD et al. () Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315 672-6 PubMed GONUTS page
↑ ^17.0 ^17.1 Jenh, CH et al. (1999) Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors. J. Immunol. 162 3765-9 PubMed GONUTS page

[PMID:16484616-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Bodnar, RJ et al. (2006) IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circ. Res. 98 617-25 PubMed GONUTS page

[PMID:8608232-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Taub, DD et al. (1996) Human interferon-inducible protein-10 induces mononuclear cell infiltration in mice and promotes the migration of human T lymphocytes into the peripheral tissues and human peripheral blood lymphocytes-SCID mice. Blood 87 1423-31 PubMed GONUTS page

[PMID:19470579-3] 3.0 ^3.1 Bodnar, RJ et al. (2009) IP-10 induces dissociation of newly formed blood vessels. J. Cell. Sci. 122 2064-77 PubMed GONUTS page

[PMID:22652417-4] Sidahmed, AM et al. (2012) CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro. Cytokine 59 433-41 PubMed GONUTS page

[PMID:11157474-5] Romagnani, P et al. (2001) Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus. Blood 97 601-7 PubMed GONUTS page

[PMID:7540647-6] Angiolillo, AL et al. (1995) Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J. Exp. Med. 182 155-62 PubMed GONUTS page

[PMID:18645041-7] 7.0 ^7.1 ^7.2 Loos, T et al. (2008) Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood 112 2648-56 PubMed GONUTS page

[PMID:20041150-8] Feng, J et al. (2009) Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. PLoS ONE 4 e8480 PubMed GONUTS page

[PMID:12782716-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Lasagni, L et al. (2003) An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J. Exp. Med. 197 1537-49 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23620790-11] Chiang, YJ et al. (2013) CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE 8 e61761 PubMed GONUTS page

[PMID:23776175-12] Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:12949249-13] 13.0 ^13.1 ^13.2 Yang, D et al. (2003) Many chemokines including CCL20/MIP-3alpha display antimicrobial activity. J. Leukoc. Biol. 74 448-55 PubMed GONUTS page

[PMID:10903763-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Jinquan, T et al. (2000) CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma. J. Immunol. 165 1548-56 PubMed GONUTS page

[PMID:8798675-15] 15.0 ^15.1 ^15.2 Wang, X et al. (1996) Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response. J. Biol. Chem. 271 24286-93 PubMed GONUTS page

[PMID:3925348-16] Luster, AD et al. () Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315 672-6 PubMed GONUTS page

[PMID:10201891-17] 17.0 ^17.1 Jenh, CH et al. (1999) Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors. J. Immunol. 162 3765-9 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

HUMAN:CXL10

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

k

l

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools