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Angiolillo, AL, Sgadari, C, Taub, DD, Liao, F, Farber, JM, Maheshwari, S, Kleinman, HK, Reaman, GH and Tosato, G (1995) Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J. Exp. Med. 182:155-62


Human interferon-inducible protein 10 (IP-10), a member of the alpha chemokine family, inhibits bone marrow colony formation, has antitumor activity in vivo, is chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells. Here we report that IP-10 is a potent inhibitor of angiogenesis in vivo. IP-10 profoundly inhibited basic fibroblast growth factor-induced neovascularization of Matrigel (prepared by H. K. Kleinman) injected subcutaneously into athymic mice. In addition, IP-10, in a dose-dependent fashion, suppressed endothelial cell differentiation into tubular capillary structures in vitro. IP-10 had no effect on endothelial cell growth, attachment, and migration as assayed in vitro. These results document an important biological property of IP-10 and raise the possibility that IP-10 may participate in the regulation of angiogenesis during inflammation and tumorigenesis.


PubMed PMC2192108


Amino Acid Sequence; Animals; Cell Adhesion/drug effects; Cell Differentiation/drug effects; Cell Division/drug effects; Cell Movement/drug effects; Cells, Cultured; Chemokine CXCL10; Chemokines, CXC; Collagen; Cytokines/pharmacology; Cytokines/therapeutic use; Drug Combinations; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Female; Fibroblast Growth Factor 2/antagonists & inhibitors; Fibroblast Growth Factor 2/toxicity; Humans; Laminin; Lung/blood supply; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Neovascularization, Pathologic/chemically induced; Neovascularization, Pathologic/prevention & control; Proteoglycans; Umbilical Veins



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status



GO:0016525: negative regulation of angiogenesis

ECO:0000314: direct assay evidence used in manual assertion


Seeded From UniProt



See also


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