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Romagnani, P, Annunziato, F, Lazzeri, E, Cosmi, L, Beltrame, C, Lasagni, L, Galli, G, Francalanci, M, Manetti, R, Marra, F, Vanini, V, Maggi, E and Romagnani, S (2001) Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus. Blood 97:601-7


Strong reactivity for interferon-inducible protein 10 (IP-10), monokine induced by interferon gamma (Mig), and interferon-inducible T-cell alpha chemoattractant (I-TAC) was found in epithelial cells mainly localized to the medulla of postnatal human thymus. The CXC chemokine receptor common to the 3 chemokines (CXCR3) was also preferentially expressed in medullary areas of the same thymuses and appeared to be a property of 4 distinct populations: CD3+ T-cell receptor (TCR) alphabeta+ CD8+ single-positive (SP) T cells, TCRgammadelta+ T cells, natural killer (NK)-type cells, and a small subset of CD3+(low) CD4+ CD8+ TCRalphabeta+ double-positive (DP) T cells. IP-10, Mig, and I-TAC showed chemoattractant activity for TCRalphabeta+ CD8+ SP T cells, TCRgammadelta+ T cells, and NK-type cells, suggesting their role in the migration of different subsets of mature thymocytes during human thymus lymphopoiesis.




CD8-Positive T-Lymphocytes/immunology; Cells, Cultured; Chemokine CXCL10; Chemokine CXCL11; Chemokine CXCL9; Chemokines, CXC/biosynthesis; Chemokines, CXC/genetics; Chemokines, CXC/immunology; Chemotaxis, Leukocyte; Epithelial Cells/immunology; Humans; Infant; Infant, Newborn; Intercellular Signaling Peptides and Proteins; Killer Cells, Natural/immunology; Lymphocyte Subsets/classification; RNA, Messenger/biosynthesis; Receptors, Antigen, T-Cell, alpha-beta/immunology; Receptors, Antigen, T-Cell, gamma-delta/immunology; Receptors, CXCR3; Receptors, Chemokine/biosynthesis; T-Lymphocytes/immunology; Thymus Gland/cytology; Thymus Gland/immunology; Thymus Gland/metabolism



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status



GO:0042056: chemoattractant activity

ECO:0000314: direct assay evidence used in manual assertion


Seeded From UniProt



See also


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