GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:CENPA

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CENPA
Protein Name(s) Histone H3-like centromeric protein A

Centromere autoantigen A Centromere protein A CENP-A

External Links
UniProt P49450
EMBL U14518
BT007246
AC011740
CH471053
CH471053
BC000881
BC002703
U82609
CCDS CCDS1729.1
CCDS42662.1
PIR I38855
RefSeq NP_001035891.1
NP_001800.1
UniGene Hs.1594
PDB 3AN2
3NQJ
3NQU
3R45
PDBsum 3AN2
3NQJ
3NQU
3R45
ProteinModelPortal P49450
SMR P49450
BioGrid 107487
DIP DIP-52297N
IntAct P49450
MINT MINT-4720873
STRING 9606.ENSP00000336868
PhosphoSite P49450
DMDM 1345726
PaxDb P49450
PRIDE P49450
DNASU 1058
Ensembl ENST00000233505
ENST00000335756
GeneID 1058
KEGG hsa:1058
UCSC uc002rhr.3
uc002rhs.3
CTD 1058
GeneCards GC02P026988
HGNC HGNC:1851
HPA CAB008371
MIM 117139
neXtProt NX_P49450
PharmGKB PA26396
eggNOG COG2036
GeneTree ENSGT00760000119422
HOGENOM HOG000155290
HOVERGEN HBG001172
InParanoid P49450
KO K11495
OMA GPRRKPE
OrthoDB EOG7KSXC2
PhylomeDB P49450
TreeFam TF354293
Reactome REACT_150425
REACT_150471
REACT_22186
REACT_682
EvolutionaryTrace P49450
GeneWiki CENPA
GenomeRNAi 1058
NextBio 4426
PRO PR:P49450
Proteomes UP000005640
Bgee P49450
CleanEx HS_CENPA
ExpressionAtlas P49450
Genevestigator P49450
GO GO:0000775
GO:0000939
GO:0000778
GO:0000780
GO:0005829
GO:0005654
GO:0000786
GO:0005634
GO:0003682
GO:0003677
GO:0034080
GO:0000132
GO:0051382
GO:0000278
GO:0006334
GO:0071459
GO:0016032
Gene3D 1.10.20.10
InterPro IPR009072
IPR007125
IPR000164
PANTHER PTHR11426
Pfam PF00125
PRINTS PR00622
SMART SM00428
SUPFAM SSF47113
PROSITE PS00959

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045885

positive regulation of survival gene product expression

PMID:21423629[1]

ECO:0000315

P

Table 2, Figure 6.

CENP-A overexpression significantly elevated protein levels of MDM2 and Bcl-2.

complete

part_of

GO:0005634

nucleus

PMID:27499292[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000281

mitotic cytokinesis

PMID:27499292[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

PMID:27499292[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000788

nuclear nucleosome

PMID:27499292[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

involved_in

GO:0071459

protein localization to chromosome, centromeric region

PMID:11682612[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051382

kinetochore assembly

PMID:11682612[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000780

condensed nuclear chromosome, centromeric region

PMID:11682612[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000778

condensed nuclear chromosome kinetochore

PMID:18195732[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000132

establishment of mitotic spindle orientation

PMID:19468067[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031492

nucleosomal DNA binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000152096
UniProtKB:Q6NXT2

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000152096
TAIR:locus:2035252
TAIR:locus:2035415
UniProtKB:P49450
UniProtKB:P59169
UniProtKB:P68431
UniProtKB:Q71DI3
WB:WBGene00001831
WB:WBGene00001946
WB:WBGene00010036
dictyBase:DDB_G0271092

C

Seeded From UniProt

complete

part_of

GO:0000786

nucleosome

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004828
PANTHER:PTN000152096
UniProtKB:P68431
UniProtKB:P84243
UniProtKB:Q16695
UniProtKB:Q6PI20
UniProtKB:Q71DI3
WB:WBGene00001946

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

PMID:11084331[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031618

nuclear pericentric heterochromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35216
ensembl:ENSMUSP00000122831

C

Seeded From UniProt

complete

part_of

GO:0000939

condensed chromosome inner kinetochore

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35216
ensembl:ENSMUSP00000122831

C

Seeded From UniProt

complete

part_of

GO:0000780

condensed nuclear chromosome, centromeric region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35216
ensembl:ENSMUSP00000122831

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35216
ensembl:ENSMUSP00000122831

C

Seeded From UniProt

complete

part_of

GO:0000786

nucleosome

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000164
InterPro:IPR007125

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000164
InterPro:IPR007125

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009072

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7962047[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:7962047[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

PMID:7962047[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0034080

CENP-A containing nucleosome assembly

Reactome:R-HSA-606279

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5666169
Reactome:R-HSA-5666160
Reactome:R-HSA-5666129
Reactome:R-HSA-375302
Reactome:R-HSA-2484822
Reactome:R-HSA-2468287
Reactome:R-HSA-2467811
Reactome:R-HSA-2467809
Reactome:R-HSA-1638821
Reactome:R-HSA-1638803
Reactome:R-HSA-141439
Reactome:R-HSA-141431
Reactome:R-HSA-141422
Reactome:R-HSA-141409

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-606326
Reactome:R-HSA-606289
Reactome:R-HSA-606287

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137
UniProtKB-SubCell:SL-0047

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0000786

nucleosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0544

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Li, Y et al. (2011) ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth. PLoS ONE 6 e17794 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Roulland, Y et al. (2016) The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity. Mol. Cell 63 674-685 PubMed GONUTS page
  3. ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Van Hooser, AA et al. (2001) Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. J. Cell. Sci. 114 3529-42 PubMed GONUTS page
  5. ↑ Chen, Q et al. (2008) Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Res. 18 268-80 PubMed GONUTS page
  6. ↑ Chan, YW et al. (2009) Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. J. Cell Biol. 185 859-74 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ Uren, AG et al. (2000) Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr. Biol. 10 1319-28 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Sullivan, KF et al. (1994) Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere. J. Cell Biol. 127 581-92 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:CENPA&oldid=5954722"