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PMID:21423629

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Citation

Li, Y, Zhu, Z, Zhang, S, Yu, D, Yu, H, Liu, L, Cao, X, Wang, L, Gao, H and Zhu, M (2011) ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth. PLoS ONE 6:e17794

Abstract

Centromere protein A (CENP-A) plays important roles in cell-cycle regulation and genetic stability. Herein, we aimed to investigate its expression pattern, clinical significance, and biological function in hepatocellular carcinoma (HCC).

Links

PubMed PMC3058037 Online version:10.1371/journal.pone.0017794

Keywords

Adult; Animals; Apoptosis/genetics; Autoantigens/genetics; Autoantigens/metabolism; Carcinoma, Hepatocellular/genetics; Carcinoma, Hepatocellular/pathology; Cell Line, Tumor; Cell Proliferation; Chromosomal Proteins, Non-Histone/genetics; Chromosomal Proteins, Non-Histone/metabolism; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genes, Neoplasm/genetics; Humans; Immunohistochemistry; Liver Neoplasms/genetics; Liver Neoplasms/pathology; Male; Mice; Mice, Nude; RNA, Small Interfering/metabolism; Xenograft Model Antitumor Assays

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:CENPA

GO:0045885: positive regulation of survival gene product expression

ECO:0000315:

P

Table 2, Figure 6.

CENP-A overexpression significantly elevated protein levels of MDM2 and Bcl-2.

complete


See also

References

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