HUMAN:CDK9

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CDK9 (synonyms: CDC2L4, TAK)
Protein Name(s)	Cyclin-dependent kinase 9 C-2K Cell division cycle 2-like protein kinase 4 Cell division protein kinase 9 Serine/threonine-protein kinase PITALRE Tat-associated kinase complex catalytic subunit
External Links
UniProt	P50750
EMBL	L25676 X80230 AF255306 BT019903 AF517840 AL162586 AL162586 BC001968
CCDS	CCDS6879.1
PIR	A55262
RefSeq	NP_001252.1
UniGene	Hs.150423 Hs.706809
PDB	1PF6 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5
PDBsum	1PF6 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5
ProteinModelPortal	P50750
SMR	P50750
BioGrid	107459
DIP	DIP-29016N
IntAct	P50750
MINT	MINT-1532814
STRING	9606.ENSP00000362361
BindingDB	P50750
ChEMBL	CHEMBL2111389
GuidetoPHARMACOLOGY	1981
PhosphoSite	P50750
DMDM	68067660
MaxQB	P50750
PaxDb	P50750
PRIDE	P50750
DNASU	1025
Ensembl	ENST00000373264
GeneID	1025
KEGG	hsa:1025
UCSC	uc004bse.2
CTD	1025
GeneCards	GC09P130547
HGNC	HGNC:1780
HPA	CAB004216 HPA006738
MIM	603251
neXtProt	NX_P50750
PharmGKB	PA26316
eggNOG	COG0515
GeneTree	ENSGT00770000120511
HOGENOM	HOG000233024
HOVERGEN	HBG014652
InParanoid	P50750
KO	K02211
OMA	HIANANF
OrthoDB	EOG76DTSM
PhylomeDB	P50750
TreeFam	TF101039
BRENDA	2.7.11.22
Reactome	REACT_120734 REACT_22107 REACT_22201 REACT_6143 REACT_6162 REACT_6244 REACT_6259 REACT_6344 REACT_6346 REACT_6905 REACT_833
SignaLink	P50750
ChiTaRS	CDK9
EvolutionaryTrace	P50750
GeneWiki	CDK9 Cyclin-dependent_kinase_9
GenomeRNAi	1025
NextBio	4305
PRO	PR:P50750
Proteomes	UP000005640
Bgee	P50750
CleanEx	HS_CDK9
ExpressionAtlas	P50750
Genevestigator	P50750
GO	GO:0005737 GO:0043231 GO:0016020 GO:0005654 GO:0005634 GO:0016605 GO:0008024 GO:0008023 GO:0005524 GO:0003682 GO:0004693 GO:0003677 GO:0004672 GO:0008353 GO:0017069 GO:0044212 GO:0008283 GO:0071345 GO:0006281 GO:0010467 GO:0071157 GO:0045944 GO:0050434 GO:0006468 GO:0006282 GO:0031056 GO:0043111 GO:0006368 GO:0006366 GO:0006367 GO:0006351 GO:0007179 GO:0016032
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001221	transcription cofactor binding	PMID:9557739^[1]	ECO:0000314			F		Figure 1b: FLAG tagged PITALRE protein bound to Tat protein complex, discerned with antibody binding	complete CACAO 8932
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:9499409^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0097322	7SK snRNA binding	PMID:11713533^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	PMID:12037672^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
part_of	GO:0008024	cyclin/CDK positive transcription elongation factor complex	PMID:9499409^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99J95	F		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:12037670^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051147	regulation of muscle cell differentiation	PMID:12037670^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19575011^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903839	positive regulation of mRNA 3'-UTR binding	PMID:19575011^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q5VTR2) has_input:(UniProtKB:O75150) has_input:(GO:0016593)	Seeded From UniProt	complete
NOT\|involved_in	GO:0007346	regulation of mitotic cell cycle	PMID:19575011^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900364	negative regulation of mRNA polyadenylation	PMID:19575011^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSG00000158373)	Seeded From UniProt	complete
involved_in	GO:2001168	positive regulation of histone H2B ubiquitination	PMID:19575011^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033129	positive regulation of histone phosphorylation	PMID:19575011^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0008023	transcription elongation factor complex	PMID:22195968^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	PMID:17956865^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	PMID:20930849^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031297	replication fork processing	PMID:20930849^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031056	regulation of histone modification	PMID:19844166^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:18250157^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:12721286^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0008024	cyclin/CDK positive transcription elongation factor complex	PMID:15905409^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006282	regulation of DNA repair	PMID:20493174^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037093 PANTHER:PTN001936021 SGD:S000001622 SGD:S000006365 UniProtKB:Q14004 UniProtKB:Q9NYV4	P		Seeded From UniProt	complete
involved_in	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037093 PANTHER:PTN000623455 SGD:S000001622 SGD:S000006365 UniProtKB:Q14004 UniProtKB:Q9NYV4	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 PANTHER:PTN000623455 UniProtKB:P50750	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1328368 PANTHER:PTN000623455	F		Seeded From UniProt	complete
involved_in	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001936021 SGD:S000006365	P		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037093 MGI:MGI:1916812 PANTHER:PTN000623455 RGD:621111 UniProtKB:Q14004 UniProtKB:Q9NYV4	F		Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 FB:FBgn0037093 MGI:MGI:1328368 PANTHER:PTN001936021 PomBase:SPAC2F3.15 PomBase:SPBC32H8.10 SGD:S000006365 UniProtKB:P50750 UniProtKB:Q14004 UniProtKB:Q9NYV4	F		Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 FB:FBgn0037093 MGI:MGI:1328368 PANTHER:PTN000623455 PomBase:SPAC2F3.15 PomBase:SPBC32H8.10 SGD:S000006365 UniProtKB:P50750 UniProtKB:Q14004 UniProtKB:Q9NYV4	F		Seeded From UniProt	complete
	GO:0050729	positive regulation of inflammatory response	PMID:26859911^[17]	ECO:0000314			P		Inhibition of CDK9 lowers uptake of pro-inflammatory cytokines.	complete CACAO 11260
enables	GO:0008134	transcription factor binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000623455 RGD:1359638	F		Seeded From UniProt	complete
part_of	GO:0008024	cyclin/CDK positive transcription elongation factor complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1328368 PANTHER:PTN000623455 UniProtKB:P50750	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013435 FB:FBgn0013762 FB:FBgn0015618 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 RGD:621124 RGD:70514 SGD:S000001622 SGD:S000001865 SGD:S000005488 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2119961 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q9UQ88 WB:WBGene00000405 WB:WBGene00000407 WB:WBGene00019362 ZFIN:ZDB-GENE-040808-34 dictyBase:DDB_G0267442 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	P		Seeded From UniProt	complete
involved_in	GO:0006368	transcription elongation from RNA polymerase II promoter	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 PANTHER:PTN000623455	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000623455 WB:WBGene00000410 WB:WBGene00007135	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015618 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:102956 MGI:MGI:104772 MGI:MGI:1328368 MGI:MGI:88353 MGI:MGI:88357 MGI:MGI:894318 PANTHER:PTN000623091 PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC32H8.10 RGD:1305435 RGD:1359638 RGD:2319 RGD:619874 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000002266 SGD:S000005952 TAIR:locus:2008595 TAIR:locus:2027819 TAIR:locus:2033349 TAIR:locus:2080290 TAIR:locus:2084086 TAIR:locus:2099478 TAIR:locus:2119961 TAIR:locus:2158554 TAIR:locus:2194045 UniProtKB:O76039 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P49336 UniProtKB:P50613 UniProtKB:P61075 UniProtKB:P79432 UniProtKB:Q00534 UniProtKB:Q00535 UniProtKB:Q00646 UniProtKB:Q5B3E4 UniProtKB:Q8IDW1 UniProtKB:Q8IIL5 UniProtKB:Q8IJQ1 UniProtKB:Q8RWN3 UniProtKB:Q8W4P1 UniProtKB:Q92772 UniProtKB:Q96VK3 UniProtKB:Q9NYV4 UniProtKB:Q9UQ88 WB:WBGene00000405 dictyBase:DDB_G0267442 dictyBase:DDB_G0288677	C		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013762 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 PomBase:SPAC23H4.17c PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC19F8.07 PomBase:SPBC32H8.10 RGD:2319 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2011761 UniProtKB:A0A1D8PDA6 UniProtKB:C9K505 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:P61075 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q8IJQ1 WB:WBGene00000405 ZFIN:ZDB-GENE-010131-2 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001936021 PomBase:SPAC2F3.15 PomBase:SPBC32H8.10	C		Seeded From UniProt	complete
part_of	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001936021 PomBase:SPBC32H8.10 SGD:S000006365	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16109376^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16109376^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q641Z4 ensembl:ENSRNOP00000037778	P		Seeded From UniProt	complete
involved_in	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q641Z4 ensembl:ENSRNOP00000037778	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q641Z4 ensembl:ENSRNOP00000037778	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q641Z4 ensembl:ENSRNOP00000037778	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q641Z4 ensembl:ENSRNOP00000037778	F		Seeded From UniProt	complete
involved_in	GO:2001168	positive regulation of histone H2B ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J95 ensembl:ENSMUSP00000009699	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J95 ensembl:ENSMUSP00000009699	F		Seeded From UniProt	complete
involved_in	GO:0033129	positive regulation of histone phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J95 ensembl:ENSMUSP00000009699	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J95 ensembl:ENSMUSP00000009699	F		Seeded From UniProt	complete
enables	GO:0017069	snRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J95 ensembl:ENSMUSP00000009699	F		Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J95 ensembl:ENSMUSP00000009699	F		Seeded From UniProt	complete
part_of	GO:0008024	cyclin/CDK positive transcription elongation factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J95 ensembl:ENSMUSP00000009699	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J95 ensembl:ENSMUSP00000009699	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J95 ensembl:ENSMUSP00000009699	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J95 ensembl:ENSMUSP00000009699	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.23	F		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.22	F		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:8170997^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0008023	transcription elongation factor complex	PMID:10866664^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006368	transcription elongation from RNA polymerase II promoter	PMID:10866664^[20] Reactome:R-HSA-75955 Reactome:R-HSA-112382	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	PMID:10866664^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:10866664^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:8170997^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050434	positive regulation of viral transcription	Reactome:R-HSA-167246	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	Reactome:R-HSA-2173796	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042795	snRNA transcription by RNA polymerase II	Reactome:R-HSA-6807505	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	Reactome:R-HSA-112381	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	Reactome:R-HSA-73857	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9012319 Reactome:R-HSA-9012315 Reactome:R-HSA-6814885 Reactome:R-HSA-6814559 Reactome:R-HSA-6814555 Reactome:R-HSA-6814549 Reactome:R-HSA-6810238 Reactome:R-HSA-6810235 Reactome:R-HSA-6810234 Reactome:R-HSA-6810233 Reactome:R-HSA-6797616 Reactome:R-HSA-6797606 Reactome:R-HSA-2176475 Reactome:R-HSA-170706 Reactome:R-HSA-170704 Reactome:R-HSA-167235 Reactome:R-HSA-167234 Reactome:R-HSA-113429 Reactome:R-HSA-113414 Reactome:R-HSA-113413 Reactome:R-HSA-113412 Reactome:R-HSA-113411 Reactome:R-HSA-112430 Reactome:R-HSA-112396 Reactome:R-HSA-112395 Reactome:R-HSA-112392 Reactome:R-HSA-112385 Reactome:R-HSA-112381 Reactome:R-HSA-112379	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-9012319	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gold, MO et al. (1998) PITALRE, the catalytic subunit of TAK, is required for human immunodeficiency virus Tat transactivation in vivo. J. Virol. 72 4448-53 PubMed GONUTS page
↑ ^2.0 ^2.1 Peng, J et al. (1998) Identification of multiple cyclin subunits of human P-TEFb. Genes Dev. 12 755-62 PubMed GONUTS page
↑ Nguyen, VT et al. (2001) 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature 414 322-5 PubMed GONUTS page
↑ Simone, C et al. (2002) Physical interaction between pRb and cdk9/cyclinT2 complex. Oncogene 21 4158-65 PubMed GONUTS page
↑ ^5.0 ^5.1 Simone, C et al. (2002) Activation of MyoD-dependent transcription by cdk9/cyclin T2. Oncogene 21 4137-48 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Pirngruber, J et al. (2009) CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. EMBO Rep. 10 894-900 PubMed GONUTS page
↑ Smith, ER et al. (2011) The little elongation complex regulates small nuclear RNA transcription. Mol. Cell 44 954-65 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Hou, T et al. (2007) The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. J. Biol. Chem. 282 37091-102 PubMed GONUTS page
↑ ^10.0 ^10.1 Yu, DS et al. (2010) Cyclin-dependent kinase 9-cyclin K functions in the replication stress response. EMBO Rep. 11 876-82 PubMed GONUTS page
↑ Pirngruber, J et al. (2009) Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing. Cell Cycle 8 3636-42 PubMed GONUTS page
↑ Sabò, A et al. (2008) Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription. Mol. Cell. Biol. 28 2201-12 PubMed GONUTS page
↑ Yeo, M et al. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J. Biol. Chem. 278 26078-85 PubMed GONUTS page
↑ Brès, V et al. (2005) A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. Genes Dev. 19 1211-26 PubMed GONUTS page
↑ Liu, H et al. (2010) 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair. Biochem. Biophys. Res. Commun. 397 245-50 PubMed GONUTS page
↑ ^16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 ^16.12 ^16.13 ^16.14 ^16.15 ^16.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hu, Z et al. (2016) Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. Eur Cell Mater 30 200-9 PubMed GONUTS page
↑ ^18.0 ^18.1 Jang, MK et al. (2005) The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 19 523-34 PubMed GONUTS page
↑ ^19.0 ^19.1 Graña, X et al. (1994) PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc. Natl. Acad. Sci. U.S.A. 91 3834-8 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Zhou, M et al. (2000) Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription. Mol. Cell. Biol. 20 5077-86 PubMed GONUTS page

[PMID:9557739-1] Gold, MO et al. (1998) PITALRE, the catalytic subunit of TAK, is required for human immunodeficiency virus Tat transactivation in vivo. J. Virol. 72 4448-53 PubMed GONUTS page

[PMID:9499409-2] 2.0 ^2.1 Peng, J et al. (1998) Identification of multiple cyclin subunits of human P-TEFb. Genes Dev. 12 755-62 PubMed GONUTS page

[PMID:11713533-3] Nguyen, VT et al. (2001) 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature 414 322-5 PubMed GONUTS page

[PMID:12037672-4] Simone, C et al. (2002) Physical interaction between pRb and cdk9/cyclinT2 complex. Oncogene 21 4158-65 PubMed GONUTS page

[PMID:12037670-5] 5.0 ^5.1 Simone, C et al. (2002) Activation of MyoD-dependent transcription by cdk9/cyclin T2. Oncogene 21 4137-48 PubMed GONUTS page

[PMID:19575011-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Pirngruber, J et al. (2009) CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. EMBO Rep. 10 894-900 PubMed GONUTS page

[PMID:22195968-7] Smith, ER et al. (2011) The little elongation complex regulates small nuclear RNA transcription. Mol. Cell 44 954-65 PubMed GONUTS page

[PMID:19946888-8] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:17956865-9] Hou, T et al. (2007) The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. J. Biol. Chem. 282 37091-102 PubMed GONUTS page

[PMID:20930849-10] 10.0 ^10.1 Yu, DS et al. (2010) Cyclin-dependent kinase 9-cyclin K functions in the replication stress response. EMBO Rep. 11 876-82 PubMed GONUTS page

[PMID:19844166-11] Pirngruber, J et al. (2009) Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing. Cell Cycle 8 3636-42 PubMed GONUTS page

[PMID:18250157-12] Sabò, A et al. (2008) Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription. Mol. Cell. Biol. 28 2201-12 PubMed GONUTS page

[PMID:12721286-13] Yeo, M et al. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J. Biol. Chem. 278 26078-85 PubMed GONUTS page

[PMID:15905409-14] Brès, V et al. (2005) A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. Genes Dev. 19 1211-26 PubMed GONUTS page

[PMID:20493174-15] Liu, H et al. (2010) 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair. Biochem. Biophys. Res. Commun. 397 245-50 PubMed GONUTS page

[PMID:21873635-16] 16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 ^16.12 ^16.13 ^16.14 ^16.15 ^16.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26859911-17] Hu, Z et al. (2016) Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. Eur Cell Mater 30 200-9 PubMed GONUTS page

[PMID:16109376-18] 18.0 ^18.1 Jang, MK et al. (2005) The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 19 523-34 PubMed GONUTS page

[PMID:8170997-19] 19.0 ^19.1 Graña, X et al. (1994) PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc. Natl. Acad. Sci. U.S.A. 91 3834-8 PubMed GONUTS page

[PMID:10866664-20] 20.0 ^20.1 ^20.2 ^20.3 Zhou, M et al. (2000) Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription. Mol. Cell. Biol. 20 5077-86 PubMed GONUTS page

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