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HUMAN:CCKN

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CCK
Protein Name(s) Cholecystokinin

CCK Cholecystokinin-58 CCK58 Cholecystokinin-58 desnonopeptide (1-49)-CCK58 Cholecystokinin-39 CCK39 Cholecystokinin-33 CCK33 Cholecystokinin-25 CCK25 Cholecystokinin-18 CCK18 Cholecystokinin-12 CCK12 Cholecystokinin-8 CCK8 Cholecystokinin-7 CCK7 Cholecystokinin-5 CCK5

External Links
UniProt P06307
EMBL L00354
BT006991
AY514491
BC008283
CCDS CCDS2696.1
PIR A01623
RefSeq NP_000720.1
NP_001167609.1
UniGene Hs.458426
ProteinModelPortal P06307
BioGrid 107327
IntAct P06307
STRING 9606.ENSP00000335657
BindingDB P06307
ChEMBL CHEMBL1649050
PhosphoSite P06307
DMDM 115945
PaxDb P06307
PRIDE P06307
DNASU 885
Ensembl ENST00000334681
ENST00000396169
ENST00000434608
GeneID 885
KEGG hsa:885
UCSC uc003cld.1
CTD 885
GeneCards GC03M042274
HGNC HGNC:1569
HPA CAB002308
MIM 118440
neXtProt NX_P06307
PharmGKB PA26141
eggNOG NOG40485
HOGENOM HOG000073533
HOVERGEN HBG005806
InParanoid P06307
KO K05226
OMA GRMSIVK
OrthoDB EOG7F7WBS
PhylomeDB P06307
TreeFam TF333419
Reactome REACT_14819
REACT_18283
ChiTaRS CCK
GeneWiki Cholecystokinin
GenomeRNAi 885
NextBio 3658
PMAP-CutDB P06307
PRO PR:P06307
Proteomes UP000005640
Bgee P06307
CleanEx HS_CCK
ExpressionAtlas P06307
Genevestigator P06307
GO GO:0030424
GO:0043203
GO:0043194
GO:0030425
GO:0005576
GO:0005615
GO:0043204
GO:0043195
GO:0005179
GO:0005184
GO:0006919
GO:0007409
GO:0001662
GO:0042755
GO:0032099
GO:0001764
GO:0008284
GO:0051901
GO:0050731
GO:0032461
GO:0007205
GO:0051930
GO:0001836
GO:0007165
InterPro IPR015499
IPR001651
IPR013152
PANTHER PTHR10786
Pfam PF00918
SMART SM00029
PROSITE PS00259

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0051428

peptide hormone receptor binding

PMID:7681836[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P32239

F

Seeded From UniProt

complete

involved_in

GO:0042755

eating behavior

PMID:15374756[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09240

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:15152034[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09240

C

Seeded From UniProt

complete

involved_in

GO:0007409

axonogenesis

PMID:15152034[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09240

P

Seeded From UniProt

complete

enables

GO:0005184

neuropeptide hormone activity

PMID:15374756[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09240

F

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

PMID:15152034[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09240

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88297
PANTHER:PTN002583982

C

Seeded From UniProt

complete

involved_in

GO:0007586

digestion

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002583982
UniProtKB:Q9PU41

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002583982
RGD:2288
UniProtKB:F1MC79
UniProtKB:P41520

C

Seeded From UniProt

complete

enables

GO:0005184

neuropeptide hormone activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88297
PANTHER:PTN002583982
RGD:2288

F

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002583982
RGD:2288

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005184

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005184

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005184

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:2000987

positive regulation of behavioral fear response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:2000986

negative regulation of behavioral fear response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:1904058

positive regulation of sensory perception of pain

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:1903999

negative regulation of eating behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0051930

regulation of sensory perception of pain

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0051901

positive regulation of mitochondrial depolarization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

C

Seeded From UniProt

complete

part_of

GO:0043203

axon hillock

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

C

Seeded From UniProt

complete

part_of

GO:0043195

terminal bouton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

C

Seeded From UniProt

complete

part_of

GO:0043194

axon initial segment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

C

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

C

Seeded From UniProt

complete

involved_in

GO:0042755

eating behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0032461

positive regulation of protein oligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0032099

negative regulation of appetite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

C

Seeded From UniProt

complete

involved_in

GO:0014049

positive regulation of glutamate secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0008542

visual learning

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0007613

memory

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0007205

protein kinase C-activating G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

C

Seeded From UniProt

complete

enables

GO:0005184

neuropeptide hormone activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

F

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

F

Seeded From UniProt

complete

involved_in

GO:0001836

release of cytochrome c from mitochondria

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01355
ensembl:ENSRNOP00000026159

P

Seeded From UniProt

complete

involved_in

GO:0042755

eating behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09240
ensembl:ENSMUSP00000149679

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09240
ensembl:ENSMUSP00000149679

C

Seeded From UniProt

complete

involved_in

GO:0007409

axonogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09240
ensembl:ENSMUSP00000149679

P

Seeded From UniProt

complete

enables

GO:0005184

neuropeptide hormone activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09240
ensembl:ENSMUSP00000149679

F

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09240
ensembl:ENSMUSP00000149679

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001651

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001651

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:10320330[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:10320330[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-388529
Reactome:R-HSA-379048

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Lee, YM et al. (1993) The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. J. Biol. Chem. 268 8164-9 PubMed GONUTS page
  2. 2.0 2.1 Hnasko, TS et al. (2004) A role for dopamine in feeding responses produced by orexigenic agents. Brain Res. 1023 309-18 PubMed GONUTS page
  3. 3.0 3.1 3.2 Giacobini, P et al. (2004) Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons. J. Neurosci. 24 4737-48 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. 5.0 5.1 Anders, J et al. (1999) Direct identification of the agonist binding site in the human brain cholecystokininB receptor. Biochemistry 38 6043-55 PubMed GONUTS page