HUMAN:CCKN

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CCK
Protein Name(s)	Cholecystokinin CCK Cholecystokinin-58 CCK58 Cholecystokinin-58 desnonopeptide (1-49)-CCK58 Cholecystokinin-39 CCK39 Cholecystokinin-33 CCK33 Cholecystokinin-25 CCK25 Cholecystokinin-18 CCK18 Cholecystokinin-12 CCK12 Cholecystokinin-8 CCK8 Cholecystokinin-7 CCK7 Cholecystokinin-5 CCK5
External Links
UniProt	P06307
EMBL	L00354 BT006991 AY514491 BC008283
CCDS	CCDS2696.1
PIR	A01623
RefSeq	NP_000720.1 NP_001167609.1
UniGene	Hs.458426
ProteinModelPortal	P06307
BioGrid	107327
IntAct	P06307
STRING	9606.ENSP00000335657
BindingDB	P06307
ChEMBL	CHEMBL1649050
PhosphoSite	P06307
DMDM	115945
PaxDb	P06307
PRIDE	P06307
DNASU	885
Ensembl	ENST00000334681 ENST00000396169 ENST00000434608
GeneID	885
KEGG	hsa:885
UCSC	uc003cld.1
CTD	885
GeneCards	GC03M042274
HGNC	HGNC:1569
HPA	CAB002308
MIM	118440
neXtProt	NX_P06307
PharmGKB	PA26141
eggNOG	NOG40485
HOGENOM	HOG000073533
HOVERGEN	HBG005806
InParanoid	P06307
KO	K05226
OMA	GRMSIVK
OrthoDB	EOG7F7WBS
PhylomeDB	P06307
TreeFam	TF333419
Reactome	REACT_14819 REACT_18283
ChiTaRS	CCK
GeneWiki	Cholecystokinin
GenomeRNAi	885
NextBio	3658
PMAP-CutDB	P06307
PRO	PR:P06307
Proteomes	UP000005640
Bgee	P06307
CleanEx	HS_CCK
ExpressionAtlas	P06307
Genevestigator	P06307
GO	GO:0030424 GO:0043203 GO:0043194 GO:0030425 GO:0005576 GO:0005615 GO:0043204 GO:0043195 GO:0005179 GO:0005184 GO:0006919 GO:0007409 GO:0001662 GO:0042755 GO:0032099 GO:0001764 GO:0008284 GO:0051901 GO:0050731 GO:0032461 GO:0007205 GO:0051930 GO:0001836 GO:0007165
InterPro	IPR015499 IPR001651 IPR013152
PANTHER	PTHR10786
Pfam	PF00918
SMART	SM00029
PROSITE	PS00259

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0051428	peptide hormone receptor binding	PMID:7681836^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P32239	F	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	PMID:15374756^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09240	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:15152034^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09240	C	Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	PMID:15152034^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09240	P	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	PMID:15374756^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09240	F	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:15152034^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09240	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88297 PANTHER:PTN002583982	C	Seeded From UniProt	complete
involved_in	GO:0007586	digestion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002583982 UniProtKB:Q9PU41	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002583982 RGD:2288 UniProtKB:F1MC79 UniProtKB:P41520	C	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88297 PANTHER:PTN002583982 RGD:2288	F	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002583982 RGD:2288	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:2000987	positive regulation of behavioral fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:2000986	negative regulation of behavioral fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:1904058	positive regulation of sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:1903999	negative regulation of eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0051901	positive regulation of mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	C	Seeded From UniProt	complete
part_of	GO:0043203	axon hillock	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	C	Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	C	Seeded From UniProt	complete
part_of	GO:0043194	axon initial segment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	C	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	C	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0032461	positive regulation of protein oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0032099	negative regulation of appetite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	C	Seeded From UniProt	complete
involved_in	GO:0014049	positive regulation of glutamate secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	C	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	F	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	F	Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01355 ensembl:ENSRNOP00000026159	P	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09240 ensembl:ENSMUSP00000149679	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09240 ensembl:ENSMUSP00000149679	C	Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09240 ensembl:ENSMUSP00000149679	P	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09240 ensembl:ENSMUSP00000149679	F	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09240 ensembl:ENSMUSP00000149679	P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001651	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001651	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10320330^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:10320330^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-388529 Reactome:R-HSA-379048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lee, YM et al. (1993) The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. J. Biol. Chem. 268 8164-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Hnasko, TS et al. (2004) A role for dopamine in feeding responses produced by orexigenic agents. Brain Res. 1023 309-18 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Giacobini, P et al. (2004) Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons. J. Neurosci. 24 4737-48 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Anders, J et al. (1999) Direct identification of the agonist binding site in the human brain cholecystokininB receptor. Biochemistry 38 6043-55 PubMed GONUTS page

[PMID:7681836-1] Lee, YM et al. (1993) The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. J. Biol. Chem. 268 8164-9 PubMed GONUTS page

[PMID:15374756-2] 2.0 ^2.1 Hnasko, TS et al. (2004) A role for dopamine in feeding responses produced by orexigenic agents. Brain Res. 1023 309-18 PubMed GONUTS page

[PMID:15152034-3] 3.0 ^3.1 ^3.2 Giacobini, P et al. (2004) Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons. J. Neurosci. 24 4737-48 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10320330-5] 5.0 ^5.1 Anders, J et al. (1999) Direct identification of the agonist binding site in the human brain cholecystokininB receptor. Biochemistry 38 6043-55 PubMed GONUTS page

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HUMAN:CCKN

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