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HUMAN:CASL
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | NEDD9 (synonyms: CASL, CASS2) | |
| Protein Name(s) | Enhancer of filamentation 1
hEF1 CRK-associated substrate-related protein CAS-L CasL Cas scaffolding protein family member 2 Neural precursor cell expressed developmentally down-regulated protein 9 NEDD-9 Renal carcinoma antigen NY-REN-12 p105 Enhancer of filamentation 1 p55 | |
| External Links | ||
| UniProt | Q14511 | |
| EMBL | L43821 U64317 AK292682 AL022098 AL136139 AL139807 AL136139 AL139807 AL139807 AL136139 AL139807 AL136139 AL512382 CH471087 CH471087 BC020686 BC040207 | |
| CCDS | CCDS34340.1 CCDS4520.1 CCDS47373.1 | |
| RefSeq | NP_001135865.1 NP_001257962.1 NP_006394.1 NP_892011.2 | |
| UniGene | Hs.37982 | |
| PDB | 2L81 | |
| PDBsum | 2L81 | |
| ProteinModelPortal | Q14511 | |
| SMR | Q14511 | |
| BioGrid | 110816 | |
| IntAct | Q14511 | |
| MINT | MINT-1175514 | |
| STRING | 9606.ENSP00000368759 | |
| PhosphoSite | Q14511 | |
| DMDM | 8134360 | |
| MaxQB | Q14511 | |
| PaxDb | Q14511 | |
| PRIDE | Q14511 | |
| DNASU | 4739 | |
| Ensembl | ENST00000379433 ENST00000379446 ENST00000504387 | |
| GeneID | 4739 | |
| KEGG | hsa:4739 | |
| UCSC | uc003mzv.2 uc003mzx.3 uc010joz.2 | |
| CTD | 4739 | |
| GeneCards | GC06M011183 | |
| HGNC | HGNC:7733 | |
| HPA | CAB009720 | |
| MIM | 602265 | |
| neXtProt | NX_Q14511 | |
| PharmGKB | PA31538 | |
| eggNOG | NOG82196 | |
| GeneTree | ENSGT00490000043324 | |
| HOGENOM | HOG000261698 | |
| HOVERGEN | HBG004354 | |
| InParanoid | Q14511 | |
| KO | K16832 | |
| OMA | YQKDVYD | |
| OrthoDB | EOG7QRQTD | |
| PhylomeDB | Q14511 | |
| TreeFam | TF328782 | |
| SignaLink | Q14511 | |
| ChiTaRS | NEDD9 | |
| GeneWiki | NEDD9 | |
| GenomeRNAi | 4739 | |
| NextBio | 18276 | |
| PMAP-CutDB | Q14511 | |
| PRO | PR:Q14511 | |
| Proteomes | UP000005640 | |
| Bgee | Q14511 | |
| CleanEx | HS_NEDD9 | |
| ExpressionAtlas | Q14511 | |
| Genevestigator | Q14511 | |
| GO | GO:0005938 GO:0005737 GO:0005925 GO:0005794 GO:0030027 GO:0005634 GO:0005819 GO:0000922 GO:0051017 GO:0007155 GO:0007010 GO:0007229 GO:0007067 GO:0040008 GO:0007165 | |
| InterPro | IPR021901 IPR014928 IPR001452 | |
| Pfam | PF12026 PF08824 PF14604 | |
| SMART | SM00326 | |
| SUPFAM | SSF50044 | |
| PROSITE | PS50002 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:2000446 |
regulation of macrophage migration inhibitory factor signaling pathway |
ECO:0000316 |
|
P |
Figure 6. The results of the paper suggest that NEDD9 promotes tumor cell migration and invasion. These results suggest that NEDD9 plays a key role in facilitating MDA-MB-231 cell migration, invasion, and growth. |
complete | ||||
|
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:1990782 |
protein tyrosine kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900026 |
positive regulation of substrate adhesion-dependent cell spreading |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061098 |
positive regulation of protein tyrosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:Q05397) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051017 |
actin filament bundle assembly |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007229 |
integrin-mediated signaling pathway |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007010 |
cytoskeleton organization |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090527 |
actin filament reorganization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002240539 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016477 |
cell migration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108091 |
P |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002240539 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002240539 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090630 |
activation of GTPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35177 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35177 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000922 |
spindle pole |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35177 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005819 |
spindle |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0040008 |
regulation of growth |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005819 |
spindle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005938 |
cell cortex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Iida, J et al. (2012) FH535 inhibited migration and growth of breast cancer cells. PLoS ONE 7 e44418 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Singh, MK et al. (2008) A novel Cas family member, HEPL, regulates FAK and cell spreading. Mol. Biol. Cell 19 1627-36 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Law, SF et al. (1998) Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. Mol. Cell. Biol. 18 3540-51 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Suzuki, T et al. (2002) MICAL, a novel CasL interacting molecule, associates with vimentin. J. Biol. Chem. 277 14933-41 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 Law, SF et al. (1996) Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Mol. Cell. Biol. 16 3327-37 PubMed GONUTS page
c
- Catarrhini
- GO:0007155 ! cell adhesion
- GO:0005938 ! cell cortex
- GO:0007049 ! cell cycle
- GO:0051301 ! cell division
- GO:0030054 ! cell junction
- GO:0016477 ! cell migration
- GO:0042995 ! cell projection
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
- GO:0007010 ! cytoskeleton organization
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
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