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HUMAN:CALCR

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CALCR
Protein Name(s) Calcitonin receptor

CT-R

External Links
UniProt P30988
EMBL L00587
X69920
U26553
U26554
X82466
S77876
S77875
AB022177
AB022178
AJ831406
AJ831407
FN994995
FN994996
AY430048
AK313996
AC003078
AC005024
CH236949
CH471091
BC069611
BC075028
CCDS CCDS55125.1
CCDS5631.1
PIR I37217
S34486
RefSeq NP_001158209.1
NP_001158210.1
NP_001733.1
UniGene Hs.489127
ProteinModelPortal P30988
SMR P30988
BioGrid 107250
IntAct P30988
MINT MINT-1217503
STRING 9606.ENSP00000352561
BindingDB P30988
ChEMBL CHEMBL2111189
DrugBank DB01278
DB00017
GuidetoPHARMACOLOGY 43
TCDB 9.A.14.4.1
PhosphoSite P30988
DMDM 550544247
PaxDb P30988
PRIDE P30988
Ensembl ENST00000394441
ENST00000415529
ENST00000423724
ENST00000426151
GeneID 799
KEGG hsa:799
UCSC uc003umv.2
CTD 799
GeneCards GC07M093053
H-InvDB HIX0033513
HGNC HGNC:1440
HPA HPA028962
MIM 114131
neXtProt NX_P30988
PharmGKB PA26032
eggNOG NOG255868
GeneTree ENSGT00760000118800
HOGENOM HOG000230695
HOVERGEN HBG102129
InParanoid P30988
KO K04576
OrthoDB EOG712TW2
TreeFam TF315710
Reactome REACT_18290
REACT_19327
ChiTaRS CALCR
GeneWiki Calcitonin_receptor
GenomeRNAi 799
NextBio 3248
PRO PR:P30988
Proteomes UP000005640
Bgee P30988
CleanEx HS_CALCR
ExpressionAtlas P30988
Genevestigator P30988
GO GO:0016021
GO:0005887
GO:0005886
GO:0032841
GO:0004948
GO:0008565
GO:0004872
GO:0007189
GO:0007186
GO:0045762
GO:0030819
GO:0007204
GO:0072659
GO:0015031
GO:0031623
GO:0051384
InterPro IPR003287
IPR017981
IPR001688
IPR001879
IPR000832
IPR017983
Pfam PF00002
PF02793
PRINTS PR00361
PR01350
PR00249
SMART SM00008
PROSITE PS00649
PS00650
PS50227
PS50261

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0150058

amylin receptor complex 3

PMID:22500019[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0150057

amylin receptor complex 2

PMID:22500019[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

PMID:22500019[1]

ECO:0000305

curator inference used in manual assertion

GO:1904645

F

Seeded From UniProt

complete

involved_in

GO:1904645

response to amyloid-beta

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896

P

Seeded From UniProt

complete

involved_in

GO:0038041

cross-receptor inhibition within G protein-coupled receptor heterodimer

PMID:14722252[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60896

P

Seeded From UniProt

complete

enables

GO:0097643

amylin receptor activity

PMID:14722252[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60894

F

Seeded From UniProt

complete

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:14722252[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60895,UniProtKB:P35318

P

Seeded From UniProt

complete

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60895,UniProtKB:P12969:PRO_0000004122

P

Seeded From UniProt

complete

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P35318

P

Seeded From UniProt

complete

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P12969:PRO_0000004122

P

Seeded From UniProt

complete

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P06881

P

Seeded From UniProt

complete

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-2173

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60895,UniProtKB:P12969:PRO_0000004122

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60895,UniProtKB:P35318

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P06881

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P35318

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P12969:PRO_0000004122

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

involved_in

GO:0010942

positive regulation of cell death

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

regulates_expression_of:(ENSEMBL:ENSG00000170345)

Seeded From UniProt

complete

involved_in

GO:0010942

positive regulation of cell death

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

Seeded From UniProt

complete

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

Seeded From UniProt

complete

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

contributes_to

GO:0097643

amylin receptor activity

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P06881
UniProtKB:O60894,UniProtKB:P10997:PRO_0000004106
UniProtKB:O60894,UniProtKB:P12969:PRO_0000004122
UniProtKB:O60894,UniProtKB:P35318
UniProtKB:O60895,UniProtKB:P12969:PRO_0000004122
UniProtKB:O60895,UniProtKB:P35318
UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

F

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

regulates_expression_of:(ENSEMBL:ENSG00000170345)

Seeded From UniProt

complete

involved_in

GO:0051897

positive regulation of protein kinase B signaling

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

Seeded From UniProt

complete

involved_in

GO:0051897

positive regulation of protein kinase B signaling

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P05067:PRO_0000000092

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

involved_in

GO:0010739

positive regulation of protein kinase A signaling

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

has_regulation_target:(UniProtKB:P13861)

Seeded From UniProt

complete

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

has_regulation_target:(UniProtKB:P13861)

Seeded From UniProt

complete

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

has_regulation_target:(UniProtKB:P13861)

Seeded From UniProt

complete

involved_in

GO:1905665

positive regulation of calcium ion import across plasma membrane

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

Seeded From UniProt

complete

involved_in

GO:1905665

positive regulation of calcium ion import across plasma membrane

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P12969:PRO_0000004122

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

part_of

GO:0150056

amylin receptor complex 1

PMID:22500019[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

PMID:11250927[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:15563840[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0032841

calcitonin binding

PMID:15563840[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01263

F

Seeded From UniProt

complete

enables

GO:0032841

calcitonin binding

PMID:8078488[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

NOT|enables

GO:0032841

calcitonin binding

PMID:15563840[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:14722252[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0007190

activation of adenylate cyclase activity

PMID:15563840[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:7619207[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:1331173[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:7588285[8]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001635

calcitonin gene-related peptide receptor activity

PMID:14722252[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60894

F

Seeded From UniProt

complete

contributes_to

GO:0097643

amylin receptor activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001381030
UniProtKB:P30988

F

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001381030
RGD:621001

C

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101950
PANTHER:PTN001381030
UniProtKB:P30988

P

Seeded From UniProt

complete

enables

GO:0004948

calcitonin receptor activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101950
PANTHER:PTN001381030
RGD:621001
UniProtKB:P25117
UniProtKB:P30988

F

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR001879
InterPro:IPR017983
InterPro:IPR036445

F

Seeded From UniProt

complete

enables

GO:0004948

calcitonin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001688
InterPro:IPR003287

F

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR003287
InterPro:IPR017983

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001688
InterPro:IPR001879
InterPro:IPR003287
InterPro:IPR036445

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017981

C

Seeded From UniProt

complete

involved_in

GO:0045762

positive regulation of adenylate cyclase activity

PMID:7588285[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045762

positive regulation of adenylate cyclase activity

PMID:7769107[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0032841

calcitonin binding

PMID:7588285[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q91157

F

Seeded From UniProt

complete

enables

GO:0032841

calcitonin binding

PMID:7769107[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

NOT|involved_in

GO:0007202

activation of phospholipase C activity

PMID:4961748[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:7619207[6]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004948

calcitonin receptor activity

PMID:7588285[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004948

P

Seeded From UniProt

complete

involved_in

GO:0045762

positive regulation of adenylate cyclase activity

PMID:7769107[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0032841

calcitonin binding

PMID:8078488[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01258

F

Seeded From UniProt

complete

enables

GO:0032841

calcitonin binding

PMID:7769107[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:8078488[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005623

cell

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0007204

C

Seeded From UniProt

complete

involved_in

GO:0045762

positive regulation of adenylate cyclase activity

PMID:7588285[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0032841

calcitonin binding

PMID:7588285[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q91157

F

Seeded From UniProt

complete

enables

GO:0004948

calcitonin receptor activity

PMID:7588285[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004948

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-744887
Reactome:R-HSA-744886
Reactome:R-HSA-420265
Reactome:R-HSA-419843
Reactome:R-HSA-379044

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 1.27 1.28 1.29 1.30 1.31 1.32 1.33 1.34 1.35 Fu, W et al. (2012) Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J. Biol. Chem. 287 18820-30 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Kuwasako, K et al. (2004) Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins. Mol. Pharmacol. 65 207-13 PubMed GONUTS page
  3. Wada, S et al. (2001) Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor. Endocrinology 142 1471-8 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Beaudreuil, J et al. (2004) Molecular characterization of two novel isoforms of the human calcitonin receptor. Gene 343 143-51 PubMed GONUTS page
  5. 5.0 5.1 5.2 Kuestner, RE et al. (1994) Cloning and characterization of an abundant subtype of the human calcitonin receptor. Mol. Pharmacol. 46 246-55 PubMed GONUTS page
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