HUMAN:BMAL1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ARNTL (synonyms: BHLHE5, BMAL1, MOP3, PASD3)
Protein Name(s)	Aryl hydrocarbon receptor nuclear translocator-like protein 1 Basic-helix-loop-helix-PAS protein MOP3 Brain and muscle ARNT-like 1 Class E basic helix-loop-helix protein 5 bHLHe5 Member of PAS protein 3 PAS domain-containing protein 3 bHLH-PAS protein JAP3
External Links
UniProt	O00327
EMBL	D89722 AB000812 AB000813 AB000814 AB000815 AB000816 U51627 U60415 AF044288 AK095749 AK291510 EF015894 AC016884 AC022878 CH471064 CH471064 CH471064 CH471064 CH471064 BC016674 BC031214 BC041129
CCDS	CCDS31430.1 CCDS44543.1 CCDS73259.1
PIR	JC5405 JC5407 PC4288 PC4289
RefSeq	NP_001025443.1 NP_001025444.1 NP_001169.3 NP_001284648.1 NP_001284651.1 NP_001284653.1 XP_006718298.1
UniGene	Hs.65734
PDB	4H10
PDBsum	4H10
ProteinModelPortal	O00327
SMR	O00327
BioGrid	106899
DIP	DIP-46008N
IntAct	O00327
PhosphoSite	O00327
MaxQB	O00327
PaxDb	O00327
PRIDE	O00327
DNASU	406
Ensembl	ENST00000389707 ENST00000401424 ENST00000403290 ENST00000403482 ENST00000403510
GeneID	406
KEGG	hsa:406
UCSC	uc001mko.3 uc001mkp.3 uc001mkr.3 uc001mks.3 uc001mkx.3 uc009ygm.1
CTD	406
GeneCards	GC11P013299
HGNC	HGNC:701
HPA	CAB045962 HPA050938 HPA054172
MIM	602550
neXtProt	NX_O00327
PharmGKB	PA24996
eggNOG	NOG293303
GeneTree	ENSGT00760000118788
HOGENOM	HOG000234379
HOVERGEN	HBG107503
InParanoid	O00327
KO	K02296
OMA	EKINTNC
OrthoDB	EOG7V1FQ8
PhylomeDB	O00327
TreeFam	TF319983
Reactome	REACT_111118 REACT_116145 REACT_118659 REACT_118789 REACT_24941
ChiTaRS	ARNTL
GeneWiki	ARNTL
GenomeRNAi	406
NextBio	1701
PRO	PR:O00327
Proteomes	UP000005640
Bgee	O00327
ExpressionAtlas	O00327
Genevestigator	O00327
GO	GO:0033391 GO:0005634 GO:0016605 GO:0005667 GO:0017162 GO:0001047 GO:0003677 GO:0070888 GO:0051879 GO:0000982 GO:0001190 GO:0043565 GO:0004871 GO:0000976 GO:0032922 GO:0007623 GO:0045599 GO:2000323 GO:0032007 GO:0045892 GO:0090403 GO:0090263 GO:0042753 GO:2001016 GO:0045944 GO:0045893 GO:0043161 GO:0000060 GO:0051726 GO:2000772 GO:0042634 GO:0050796 GO:0050767 GO:0042176 GO:0006355 GO:2000074 GO:0051775 GO:0007283
Gene3D	4.10.280.10
InterPro	IPR011598 IPR001067 IPR001610 IPR000014 IPR013767
Pfam	PF00010 PF00989
PRINTS	PR00785
SMART	SM00353 SM00086 SM00091
SUPFAM	SSF47459 SSF55785
TIGRFAMs	TIGR00229
PROSITE	PS50888 PS50112

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001067 InterPro:IPR011598	F	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:25749863^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P97481	F	Seeded From UniProt	complete
involved_in	GO:1901985	positive regulation of protein acetylation	PMID:28985504^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:25936801^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IV76	F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21628546^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:9079689^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20093779^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017162	aryl hydrocarbon receptor binding	PMID:9079689^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35869	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	F	Seeded From UniProt	complete
involved_in	GO:2001016	positive regulation of skeletal muscle cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:2000772	regulation of cellular senescence	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:2000074	regulation of type B pancreatic cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:0090403	oxidative stress-induced premature senescence	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:23785138^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:12738229^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051775	response to redox state	PMID:11441146^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11441146^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:23785138^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12738229^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08785	P	Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	F	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:0042753	positive regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:0042634	regulation of hair cycle	PMID:24005054^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0033391	chromatoid body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	C	Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:24005054^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24005054^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11441146^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTL8	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9576906^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99814	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9576906^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99743	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9576906^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q16665	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9576906^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O15516	P	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:9576906^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99814	C	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:9576906^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99743	C	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:9576906^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16665	C	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:9576906^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15516	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9576906^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99743	F	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2001016	positive regulation of skeletal muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:2000772	regulation of cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:2000074	regulation of type B pancreatic cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:1901985	positive regulation of protein acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0090403	oxidative stress-induced premature senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
involved_in	GO:0060137	maternal process involved in parturition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0051775	response to redox state	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0042753	positive regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0042176	regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
part_of	GO:0033391	chromatoid body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	C	Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	C	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	C	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTL8 ensembl:ENSMUSP00000147989	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	C	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067 InterPro:IPR013767	P	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:9616112^[13] Reactome:R-HSA-400253	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5663170 Reactome:R-HSA-5663138 Reactome:R-HSA-5663124	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Nam, D et al. (2015) The adipocyte clock controls brown adipogenesis through the TGF-β and BMP signaling pathways. J. Cell. Sci. 128 1835-47 PubMed GONUTS page
↑ Lin, R et al. (2017) CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol. Cell 68 198-209.e6 PubMed GONUTS page
↑ Michael, AK et al. (2015) Cancer/Testis Antigen PASD1 Silences the Circadian Clock. Mol. Cell 58 743-54 PubMed GONUTS page
↑ Poliandri, AH et al. (2011) Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140). J. Biol. Rhythms 26 187-99 PubMed GONUTS page
↑ ^6.0 ^6.1 Hogenesch, JB et al. (1997) Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem. 272 8581-93 PubMed GONUTS page
↑ Takahashi, S et al. (2010) A promoter in the novel exon of hPPARgamma directs the circadian expression of PPARgamma. J. Atheroscler. Thromb. 17 73-83 PubMed GONUTS page
↑ ^8.0 ^8.1 Baeza-Raja, B et al. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 33 10221-34 PubMed GONUTS page
↑ ^9.0 ^9.1 Schoenhard, JA et al. (2003) Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2. J. Mol. Cell. Cardiol. 35 473-81 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Rutter, J et al. (2001) Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science 293 510-4 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Al-Nuaimi, Y et al. (2014) A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock. J. Invest. Dermatol. 134 610-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 Hogenesch, JB et al. (1998) The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. U.S.A. 95 5474-9 PubMed GONUTS page
↑ Gekakis, N et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280 1564-9 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:25749863-2] Nam, D et al. (2015) The adipocyte clock controls brown adipogenesis through the TGF-β and BMP signaling pathways. J. Cell. Sci. 128 1835-47 PubMed GONUTS page

[PMID:28985504-3] Lin, R et al. (2017) CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol. Cell 68 198-209.e6 PubMed GONUTS page

[PMID:25936801-4] Michael, AK et al. (2015) Cancer/Testis Antigen PASD1 Silences the Circadian Clock. Mol. Cell 58 743-54 PubMed GONUTS page

[PMID:21628546-5] Poliandri, AH et al. (2011) Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140). J. Biol. Rhythms 26 187-99 PubMed GONUTS page

[PMID:9079689-6] 6.0 ^6.1 Hogenesch, JB et al. (1997) Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem. 272 8581-93 PubMed GONUTS page

[PMID:20093779-7] Takahashi, S et al. (2010) A promoter in the novel exon of hPPARgamma directs the circadian expression of PPARgamma. J. Atheroscler. Thromb. 17 73-83 PubMed GONUTS page

[PMID:23785138-8] 8.0 ^8.1 Baeza-Raja, B et al. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 33 10221-34 PubMed GONUTS page

[PMID:12738229-9] 9.0 ^9.1 Schoenhard, JA et al. (2003) Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2. J. Mol. Cell. Cardiol. 35 473-81 PubMed GONUTS page

[PMID:11441146-10] 10.0 ^10.1 ^10.2 Rutter, J et al. (2001) Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science 293 510-4 PubMed GONUTS page

[PMID:24005054-11] 11.0 ^11.1 ^11.2 Al-Nuaimi, Y et al. (2014) A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock. J. Invest. Dermatol. 134 610-9 PubMed GONUTS page

[PMID:9576906-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 Hogenesch, JB et al. (1998) The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. U.S.A. 95 5474-9 PubMed GONUTS page

[PMID:9616112-13] Gekakis, N et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280 1564-9 PubMed GONUTS page

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