HUMAN:BECN1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BECN1 (synonyms: GT197)
Protein Name(s)	Beclin-1 Coiled-coil myosin-like BCL2-interacting protein Protein GT197
External Links
UniProt	Q14457
EMBL	AF077301 AF139131 AK312651 BC010276 L38932
CCDS	CCDS11441.1
PIR	I54209
RefSeq	NP_003757.1 XP_005257815.1
UniGene	Hs.716464
PDB	2P1L 2PON 3DVU 4DDP 4MI8
PDBsum	2P1L 2PON 3DVU 4DDP 4MI8
ProteinModelPortal	Q14457
SMR	Q14457
BioGrid	114226
DIP	DIP-44611N
IntAct	Q14457
MINT	MINT-2865445
STRING	9606.ENSP00000355231
PhosphoSite	Q14457
DMDM	13124704
MaxQB	Q14457
PaxDb	Q14457
PRIDE	Q14457
DNASU	8678
Ensembl	ENST00000361523 ENST00000590099
GeneID	8678
KEGG	hsa:8678
UCSC	uc002ibn.2
CTD	8678
GeneCards	GC17M040963
HGNC	HGNC:1034
HPA	CAB010143
MIM	604378
neXtProt	NX_Q14457
PharmGKB	PA25337
eggNOG	NOG285533
GeneTree	ENSGT00390000008164
HOGENOM	HOG000158093
HOVERGEN	HBG003181
InParanoid	Q14457
KO	K08334
OMA	YIPPARM
OrthoDB	EOG7D2FDG
PhylomeDB	Q14457
TreeFam	TF314282
ChiTaRS	BECN1
EvolutionaryTrace	Q14457
GeneWiki	BECN1
GenomeRNAi	8678
NextBio	32555
PRO	PR:Q14457
Proteomes	UP000005640
Bgee	Q14457
CleanEx	HS_BECN1
ExpressionAtlas	Q14457
Genevestigator	Q14457
GO	GO:0016020 GO:0045335 GO:0043234 GO:0005802 GO:0006914 GO:0050435 GO:0006968 GO:0000910 GO:0051607 GO:0007040 GO:0043066 GO:0008285 GO:0048666 GO:0016239 GO:0050790 GO:0016032
InterPro	IPR007243 IPR029318
PANTHER	PTHR12768
Pfam	PF04111 PF15285

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006914	autophagy	PMID:24056303^[1]	ECO:0000315			P		According to Supplemental Figure 7 a and b, a mutation in beclin-1 results in the improper autophagy-induced dispersal of of fluorescent Atg9, compared to an even dispersal in the control.	complete CACAO 9031
	GO:0007080	mitotic metaphase plate congression	PMID:23478334^[2]	ECO:0000315			P		According to Figure 1e, knockdown of beclin 1 leads to a significant increase in misalignment at the metaphase plate during mitosis, compared to the almost negligible number of misalignments in the wild type.	complete CACAO 9042
	GO:1902425	positive regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation	PMID:23478334^[2]	ECO:0000315			P		As shown in Figure 3B, a knockdown in Beclin 1 results in the improper attachment of microtubules to kinetochore proteins, as compared to the orderly attachment seen in the wild type.	complete CACAO 9045
enables	GO:0019901	protein kinase binding	PMID:27853422^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13464	F	positively_regulates:(GO:0097242) positively_regulates:(GO:0006914)	Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91XJ1	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMID:27031958^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051020	GTPase binding	PMID:25891078^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:A1A4Y4	F		Seeded From UniProt	complete
involved_in	GO:0098780	response to mitochondrial depolarisation	PMID:23878393^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:25127057^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0CI25	F		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:23629966^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:25215947^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045022	early endosome to late endosome transport	PMID:26783301^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	PMID:20643123^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032801	receptor catabolic process	PMID:20643123^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:25127057^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IYM9	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	PMID:23878393^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8NEB9	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:23878393^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:23878393^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	PMID:23878393^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005739	mitochondrion	PMID:23878393^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000423	mitophagy	PMID:23878393^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0098780)	Seeded From UniProt	complete
involved_in	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	PMID:23478334^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007080	mitotic metaphase plate congression	PMID:23478334^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:24056303^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035032	phosphatidylinositol 3-kinase complex, class III	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88597	C		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88597	P		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88597	P		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	PMID:25215947^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:23184933^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88597	P		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	PMID:20208530^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045324	late endosome to vacuole transport	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 SGD:S000006041	P		Seeded From UniProt	complete
part_of	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 SGD:S000006041	C		Seeded From UniProt	complete
part_of	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264325 PANTHER:PTN000298965 SGD:S000006041	C		Seeded From UniProt	complete
involved_in	GO:0032258	protein localization by the Cvt pathway	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 SGD:S000006041	P		Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 SGD:S000006041 UniProtKB:Q14457	C		Seeded From UniProt	complete
involved_in	GO:0006995	cellular response to nitrogen starvation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 dictyBase:DDB_G0269244	P		Seeded From UniProt	complete
part_of	GO:0000407	phagophore assembly site	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 PomBase:SPAC20G8.10c	C		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1891828 PANTHER:PTN000298965 RGD:620190	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:19273585^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:1902902	negative regulation of autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0051707	response to other organism	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	C		Seeded From UniProt	complete
involved_in	GO:0043652	engulfment of apoptotic cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	F		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
part_of	GO:0035032	phosphatidylinositol 3-kinase complex, class III	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	C		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0007040	lysosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	C		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88597 ensembl:ENSMUSP00000119369	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:2000786	positive regulation of autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:1905672	negative regulation of lysosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0071275	cellular response to aluminum ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0033197	response to vitamin E	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	C		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0010040	response to iron(II) ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032913	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007243 InterPro:IPR032913	P		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032913	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9765397^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006968	cellular defense response	PMID:9765397^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	Reactome:R-HSA-1632852	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6781779 Reactome:R-HSA-5682385 Reactome:R-HSA-5679266 Reactome:R-HSA-5679205 Reactome:R-HSA-5678315 Reactome:R-HSA-5678313 Reactome:R-HSA-5672012 Reactome:R-HSA-1632857	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0023	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 He, S et al. (2013) PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat. Cell Biol. 15 1206-19 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Frémont, S et al. (2013) Beclin-1 is required for chromosome congression and proper outer kinetochore assembly. EMBO Rep. 14 364-72 PubMed GONUTS page
↑ Hu, YB et al. (2016) ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance. Front Cell Neurosci 10 253 PubMed GONUTS page
↑ Cai, D et al. (2016) Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death Dis 7 e2161 PubMed GONUTS page
↑ Chauhan, S et al. (2015) IRGM governs the core autophagy machinery to conduct antimicrobial defense. Mol. Cell 58 507-21 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Fogel, AI et al. (2013) Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol. Cell. Biol. 33 3675-88 PubMed GONUTS page
↑ ^7.0 ^7.1 Mandell, MA et al. (2014) TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev. Cell 30 394-409 PubMed GONUTS page
↑ Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page
↑ ^9.0 ^9.1 Strappazzon, F et al. (2015) AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. Cell Death Differ. 22 419-32 PubMed GONUTS page
↑ Liu, K et al. (2016) Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. J. Cell Biol. 212 181-98 PubMed GONUTS page
↑ ^11.0 ^11.1 Thoresen, SB et al. (2010) A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp. Cell Res. 316 3368-78 PubMed GONUTS page
↑ Margariti, A et al. (2013) XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J. Biol. Chem. 288 859-72 PubMed GONUTS page
↑ Sagona, AP et al. (2010) PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat. Cell Biol. 12 362-71 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Bellot, G et al. (2009) Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell. Biol. 29 2570-81 PubMed GONUTS page
↑ ^16.0 ^16.1 Liang, XH et al. (1998) Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72 8586-96 PubMed GONUTS page

[PMID:24056303-1] 1.0 ^1.1 He, S et al. (2013) PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat. Cell Biol. 15 1206-19 PubMed GONUTS page

[PMID:23478334-2] 2.0 ^2.1 ^2.2 ^2.3 Frémont, S et al. (2013) Beclin-1 is required for chromosome congression and proper outer kinetochore assembly. EMBO Rep. 14 364-72 PubMed GONUTS page

[PMID:27853422-3] Hu, YB et al. (2016) ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance. Front Cell Neurosci 10 253 PubMed GONUTS page

[PMID:27031958-4] Cai, D et al. (2016) Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death Dis 7 e2161 PubMed GONUTS page

[PMID:25891078-5] Chauhan, S et al. (2015) IRGM governs the core autophagy machinery to conduct antimicrobial defense. Mol. Cell 58 507-21 PubMed GONUTS page

[PMID:23878393-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Fogel, AI et al. (2013) Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol. Cell. Biol. 33 3675-88 PubMed GONUTS page

[PMID:25127057-7] 7.0 ^7.1 Mandell, MA et al. (2014) TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev. Cell 30 394-409 PubMed GONUTS page

[PMID:23629966-8] Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page

[PMID:25215947-9] 9.0 ^9.1 Strappazzon, F et al. (2015) AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. Cell Death Differ. 22 419-32 PubMed GONUTS page

[PMID:26783301-10] Liu, K et al. (2016) Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. J. Cell Biol. 212 181-98 PubMed GONUTS page

[PMID:20643123-11] 11.0 ^11.1 Thoresen, SB et al. (2010) A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp. Cell Res. 316 3368-78 PubMed GONUTS page

[PMID:23184933-12] Margariti, A et al. (2013) XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J. Biol. Chem. 288 859-72 PubMed GONUTS page

[PMID:20208530-13] Sagona, AP et al. (2010) PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat. Cell Biol. 12 362-71 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19273585-15] Bellot, G et al. (2009) Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell. Biol. 29 2570-81 PubMed GONUTS page

[PMID:9765397-16] 16.0 ^16.1 Liang, XH et al. (1998) Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72 8586-96 PubMed GONUTS page

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HUMAN:BECN1

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