HUMAN:B2L11

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BCL2L11 (synonyms: BIM)
Protein Name(s)	Bcl-2-like protein 11 Bcl2-L-11 Bcl2-interacting mediator of cell death
External Links
UniProt	O43521
EMBL	AF032457 AF032458 AB071195 AB071196 AB071197 AB071198 AB071199 AB071200 AY352518 AY305714 AY305715 AY423441 AY423442 AY423443 AY428962 DQ849200 DQ849201 DQ849202 AK290377 AK291269 AC096670 CH471237 CH471237 CH471237 CH471237 CH471237 CH471237 CH471237 CH471237 BC033694
CCDS	CCDS2089.1 CCDS2092.1 CCDS42731.1 CCDS56131.1 CCDS56132.1 CCDS56133.1 CCDS56134.1 CCDS56135.1 CCDS56136.1 CCDS74560.1 CCDS74561.1
RefSeq	NP_001191035.1 NP_001191036.1 NP_001191037.1 NP_001191038.1 NP_001191039.1 NP_001191040.1 NP_001191041.1 NP_001191042.1 NP_006529.1 NP_619527.1 NP_619528.1 NP_619529.1 NP_619530.1 NP_619531.1 NP_619532.1 NP_619533.1 NP_996885.1 NP_996886.1
UniGene	Hs.469658 Hs.737004
PDB	1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4B4S 4D2M
PDBsum	1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4B4S 4D2M
DisProt	DP00643
ProteinModelPortal	O43521
SMR	O43521
BioGrid	115335
DIP	DIP-29185N
IntAct	O43521
MINT	MINT-1664421
BindingDB	O43521
ChEMBL	CHEMBL5777
PhosphoSite	O43521
MaxQB	O43521
PaxDb	O43521
PRIDE	O43521
DNASU	10018
Ensembl	ENST00000308659 ENST00000337565 ENST00000361493 ENST00000393256 ENST00000405953 ENST00000415458 ENST00000431217 ENST00000433098 ENST00000436733 ENST00000437029 ENST00000439718 ENST00000452231 ENST00000610735 ENST00000615946 ENST00000619294 ENST00000620862 ENST00000621302 ENST00000622509 ENST00000622612
GeneID	10018
KEGG	hsa:10018
UCSC	uc002tgt.1 uc002tgu.1 uc002tgv.1 uc002tgw.2 uc002tgx.2 uc002tgy.2 uc002tgz.2 uc002tha.2 uc002thb.2 uc002thc.2 uc002thd.2 uc010fkd.2 uc021vmp.1 uc021vmq.1 uc021vmr.1 uc021vms.1
CTD	10018
GeneCards	GC02P111876
HGNC	HGNC:994
HPA	CAB026332
MIM	603827
neXtProt	NX_O43521
PharmGKB	PA25305
eggNOG	NOG40262
GeneTree	ENSGT00390000003178
InParanoid	O43521
KO	K16341
PhylomeDB	O43521
TreeFam	TF335898
Reactome	REACT_13638 REACT_330
ChiTaRS	BCL2L11
EvolutionaryTrace	O43521
GeneWiki	BCL2L11
GenomeRNAi	10018
NextBio	37849
PMAP-CutDB	O43521
PRO	PR:O43521
Proteomes	UP000005640
Bgee	O43521
ExpressionAtlas	O43521
Genevestigator	O43521
GO	GO:0097141 GO:0097140 GO:0005829 GO:0012505 GO:0019898 GO:0005741 GO:0006919 GO:0006915 GO:1902263 GO:0097190 GO:0001783 GO:0001782 GO:0007420 GO:0007160 GO:0060154 GO:0048066 GO:0043583 GO:0097192 GO:0001701 GO:0097193 GO:0008630 GO:0001822 GO:0008584 GO:0030879 GO:0002262 GO:0048011 GO:0042475 GO:0043065 GO:0060139 GO:0045787 GO:0043280 GO:2000271 GO:2001244 GO:1902110 GO:0043525 GO:0032464 GO:1900740 GO:0090200 GO:0048563 GO:0048070 GO:0046620 GO:0034976 GO:0007283 GO:0048536 GO:0043029 GO:0070242 GO:0048538 GO:0035148
InterPro	IPR014771 IPR017288 IPR015040
Pfam	PF08945 PF06773
PIRSF	PIRSF037827

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:21041309^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70444	P		Seeded From UniProt	complete
involved_in	GO:0032464	positive regulation of protein homooligomerization	PMID:21041309^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000271	positive regulation of fibroblast apoptotic process	PMID:11997495^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:17289999^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:17289999^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:22761832^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1197519 PANTHER:PTN001738900 UniProtKB:O43521	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1197519 PANTHER:PTN001738900 UniProtKB:O43521	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1197519 PANTHER:PTN001738900 RGD:628774	C		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:11546872^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902263	apoptotic process involved in embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:1902110	positive regulation of mitochondrial membrane permeability involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
part_of	GO:0097136	Bcl-2 family protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	C		Seeded From UniProt	complete
involved_in	GO:0070242	thymocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0060154	cellular process regulating host cell cycle in response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0060139	positive regulation of apoptotic process by virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0048563	post-embryonic animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0048536	spleen development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0048070	regulation of developmental pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0048066	developmental pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	F		Seeded From UniProt	complete
involved_in	GO:0046620	regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0043583	ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0043029	T cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0035148	tube formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	F		Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	C		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	F		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0007160	cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	C		Seeded From UniProt	complete
involved_in	GO:0002262	myeloid cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0002260	lymphocyte homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0001783	B cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0001782	B cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0001776	leukocyte homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54918 ensembl:ENSMUSP00000105970	P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88498 ensembl:ENSRNOP00000039006	P		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88498 ensembl:ENSRNOP00000039006	P		Seeded From UniProt	complete
involved_in	GO:0034263	positive regulation of autophagy in response to ER overload	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88498 ensembl:ENSRNOP00000039006	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88498 ensembl:ENSRNOP00000039006	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88498 ensembl:ENSRNOP00000039006	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88498 ensembl:ENSRNOP00000039006	C		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMID:21671007^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097141	BIM-BCL-2 complex	PMID:21671007^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097140	BIM-BCL-xl complex	PMID:21671007^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:21671007^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0008017	microtubule binding	PMID:21671007^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21671007^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005874	microtubule	PMID:21671007^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21671007^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	PMID:20371704^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:20371704^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0071385)	Seeded From UniProt	complete
involved_in	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	PMID:22013210^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903896	positive regulation of IRE1-mediated unfolded protein response	PMID:22013210^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:9731710^[10] PMID:10381623^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Reactome:R-HSA-111453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8952232 Reactome:R-HSA-205075 Reactome:R-HSA-139919 Reactome:R-HSA-139918	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	Reactome:R-HSA-8870686 Reactome:R-HSA-508163 Reactome:R-HSA-508162 Reactome:R-HSA-139919	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001844	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Reactome:R-HSA-139919	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Du, H et al. (2011) BH3 domains other than Bim and Bid can directly activate Bax/Bak. J. Biol. Chem. 286 491-501 PubMed GONUTS page
↑ Marani, M et al. (2002) Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol. Cell. Biol. 22 3577-89 PubMed GONUTS page
↑ ^3.0 ^3.1 Willis, SN et al. (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315 856-9 PubMed GONUTS page
↑ Ghosh, AP et al. (2012) CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE 7 e39586 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Puthalakath, H et al. (2001) Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 293 1829-32 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Mendez, G et al. (2011) Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4. Apoptosis 16 940-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Spokoini, R et al. (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol. Endocrinol. 24 1136-50 PubMed GONUTS page
↑ ^9.0 ^9.1 Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page
↑ Hsu, SY et al. (1998) BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol. Endocrinol. 12 1432-40 PubMed GONUTS page
↑ Ohi, N et al. (1999) A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. Cell Death Differ. 6 314-25 PubMed GONUTS page

[PMID:21041309-1] 1.0 ^1.1 Du, H et al. (2011) BH3 domains other than Bim and Bid can directly activate Bax/Bak. J. Biol. Chem. 286 491-501 PubMed GONUTS page

[PMID:11997495-2] Marani, M et al. (2002) Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol. Cell. Biol. 22 3577-89 PubMed GONUTS page

[PMID:17289999-3] 3.0 ^3.1 Willis, SN et al. (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315 856-9 PubMed GONUTS page

[PMID:22761832-4] Ghosh, AP et al. (2012) CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE 7 e39586 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11546872-6] Puthalakath, H et al. (2001) Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 293 1829-32 PubMed GONUTS page

[PMID:21671007-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Mendez, G et al. (2011) Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4. Apoptosis 16 940-9 PubMed GONUTS page

[PMID:20371704-8] 8.0 ^8.1 Spokoini, R et al. (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol. Endocrinol. 24 1136-50 PubMed GONUTS page

[PMID:22013210-9] 9.0 ^9.1 Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page

[PMID:9731710-10] Hsu, SY et al. (1998) BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol. Endocrinol. 12 1432-40 PubMed GONUTS page

[PMID:10381623-11] Ohi, N et al. (1999) A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. Cell Death Differ. 6 314-25 PubMed GONUTS page

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HUMAN:B2L11

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