HUMAN:ARRB1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ARRB1 (synonyms: ARR1)
Protein Name(s)	Beta-arrestin-1 Arrestin beta-1
External Links
UniProt	P49407
EMBL	L04685 L04685 AF084040 AF084940 DQ314865 FJ348262 CH471076 BC003636
CCDS	CCDS31640.1 CCDS44684.1
PIR	B46682
RefSeq	NP_004032.2 NP_064647.1
UniGene	Hs.503284 Hs.625320
PDB	2IV8
PDBsum	2IV8
ProteinModelPortal	P49407
SMR	P49407
BioGrid	106901
DIP	DIP-29979N
IntAct	P49407
MINT	MINT-128176
STRING	9606.ENSP00000377141
BindingDB	P49407
ChEMBL	CHEMBL1795088
PhosphoSite	P49407
DMDM	20141238
OGP	P49407
MaxQB	P49407
PaxDb	P49407
PRIDE	P49407
DNASU	408
Ensembl	ENST00000360025 ENST00000420843
GeneID	408
KEGG	hsa:408
UCSC	uc001owe.2 uc001owf.2
CTD	408
GeneCards	GC11M074976
HGNC	HGNC:711
HPA	CAB003763
MIM	107940
neXtProt	NX_P49407
PharmGKB	PA59
eggNOG	NOG302111
GeneTree	ENSGT00390000013152
HOGENOM	HOG000231319
HOVERGEN	HBG002399
InParanoid	P49407
KO	K04439
OMA	EAPIDTN
OrthoDB	EOG79W954
PhylomeDB	P49407
TreeFam	TF314260
Reactome	REACT_118614 REACT_19287 REACT_19400 REACT_21384
SignaLink	P49407
ChiTaRS	ARRB1
EvolutionaryTrace	P49407
GeneWiki	Arrestin_beta_1
GenomeRNAi	408
NextBio	1713
PRO	PR:P49407
Proteomes	UP000005640
Bgee	P49407
CleanEx	HS_ARRB1
ExpressionAtlas	P49407
Genevestigator	P49407
GO	GO:0000785 GO:0005905 GO:0005737 GO:0031410 GO:0030659 GO:0005829 GO:0000139 GO:0005765 GO:0005634 GO:0005886 GO:0031143 GO:0031701 GO:0043027 GO:0004857 GO:0005096 GO:0005159 GO:0008134 GO:0044212 GO:0031625 GO:0007596 GO:0002031 GO:0061024 GO:0032715 GO:0032717 GO:0032088 GO:0031397 GO:0007219 GO:0007602 GO:0030168 GO:0070374 GO:0043547 GO:0035066 GO:0090240 GO:0035774 GO:0033138 GO:0032092 GO:0001934 GO:0002092 GO:0035025 GO:0045944 GO:0006892 GO:0043161 GO:0015031 GO:0016567 GO:0043149 GO:0006366
Gene3D	2.60.40.640 2.60.40.840
InterPro	IPR000698 IPR011021 IPR014752 IPR011022 IPR017864 IPR014753 IPR014756
PANTHER	PTHR11792
Pfam	PF02752 PF00339
PRINTS	PR00309
SMART	SM01017
SUPFAM	SSF81296
PROSITE	PS00295

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:1990763	arrestin family protein binding	PMID:23886940^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8N5I2	F	Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	PMID:23886940^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:23886940^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16325578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:16325578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:16325578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:16325578^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090240	positive regulation of histone H4 acetylation	PMID:16325578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:10644702^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:15878855^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043149	stress fiber assembly	PMID:15611106^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	PMID:15611106^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032717	negative regulation of interleukin-8 production	PMID:16378096^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	PMID:16378096^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:16378096^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031701	angiotensin receptor binding	PMID:15611106^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P30556	F	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:15878855^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00987	F	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:15611106^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:16378096^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:15878855^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:16325578^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16220	F	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:16325578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10823817^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16325578^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15611106^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16325578^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	PMID:15878855^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08069	F	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:15611106^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
NOT\|enables	GO:0004402	histone acetyltransferase activity	PMID:16325578^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:22457824^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	PMID:12582207^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	PMID:10521508^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:23633677^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0043027	P	Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004402	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
enables	GO:1990763	arrestin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
enables	GO:0045309	protein phosphorylated amino acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	C	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0042699	follicle-stimulating hormone signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
enables	GO:0035615	clathrin adaptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
enables	GO:0035612	AP-2 adaptor complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
involved_in	GO:0034393	positive regulation of smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
enables	GO:0031896	V2 vasopressin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
enables	GO:0031762	follicle-stimulating hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
enables	GO:0031692	alpha-1B adrenergic receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
enables	GO:0031691	alpha-1A adrenergic receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	C	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	C	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	F	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29066 ensembl:ENSRNOP00000046069	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	P	Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	P	Seeded From UniProt	complete
enables	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	F	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	P	Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	P	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	P	Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	P	Seeded From UniProt	complete
enables	GO:0031434	mitogen-activated protein kinase kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	F	Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	C	Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	P	Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	P	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BWG8 ensembl:ENSMUSP00000095866	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000698 InterPro:IPR014753	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9924018^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004857	enzyme inhibitor activity	PMID:2163110^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	Reactome:R-HSA-421836 Reactome:R-HSA-421835	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-8868230 Reactome:R-HSA-8868072 Reactome:R-HSA-8868071 Reactome:R-HSA-8867756 Reactome:R-HSA-8867754 Reactome:R-HSA-8866283 Reactome:R-HSA-8866269 Reactome:R-HSA-8852167 Reactome:R-HSA-432712 Reactome:R-HSA-432688 Reactome:R-HSA-421836 Reactome:R-HSA-421833 Reactome:R-HSA-418170 Reactome:R-HSA-418163 Reactome:R-HSA-418158 Reactome:R-HSA-418091	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	Reactome:R-HSA-432707 Reactome:R-HSA-432688	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-432712 Reactome:R-HSA-432707 Reactome:R-HSA-432706 Reactome:R-HSA-421835 Reactome:R-HSA-421833 Reactome:R-HSA-421831	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P	Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0298	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Puca, L et al. (2013) Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals. J. Cell. Sci. 126 4457-68 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Kang, J et al. (2005) A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123 833-47 PubMed GONUTS page
↑ Cheng, ZJ et al. (2000) beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J. Biol. Chem. 275 2479-85 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Girnita, L et al. (2005) {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J. Biol. Chem. 280 24412-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Barnes, WG et al. (2005) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J. Biol. Chem. 280 8041-50 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page
↑ Bennett, TA et al. (2000) Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence. J. Biol. Chem. 275 24590-4 PubMed GONUTS page
↑ Canals, M et al. (2012) Ubiquitination of CXCR7 controls receptor trafficking. PLoS ONE 7 e34192 PubMed GONUTS page
↑ Ahn, S et al. (2003) Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proc. Natl. Acad. Sci. U.S.A. 100 1740-4 PubMed GONUTS page
↑ Orsini, MJ et al. (1999) Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J. Biol. Chem. 274 31076-86 PubMed GONUTS page
↑ Borroni, EM et al. (2013) β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Sci Signal 6 ra30.1-11, S1-3 PubMed GONUTS page
↑ Luttrell, LM et al. (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283 655-61 PubMed GONUTS page
↑ Lohse, MJ et al. (1990) beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science 248 1547-50 PubMed GONUTS page

[PMID:23886940-1] 1.0 ^1.1 ^1.2 Puca, L et al. (2013) Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals. J. Cell. Sci. 126 4457-68 PubMed GONUTS page

[PMID:16325578-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Kang, J et al. (2005) A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123 833-47 PubMed GONUTS page

[PMID:10644702-3] Cheng, ZJ et al. (2000) beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J. Biol. Chem. 275 2479-85 PubMed GONUTS page

[PMID:15878855-4] 4.0 ^4.1 ^4.2 ^4.3 Girnita, L et al. (2005) {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J. Biol. Chem. 280 24412-9 PubMed GONUTS page

[PMID:15611106-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Barnes, WG et al. (2005) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J. Biol. Chem. 280 8041-50 PubMed GONUTS page

[PMID:16378096-6] 6.0 ^6.1 ^6.2 ^6.3 Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page

[PMID:10823817-7] Bennett, TA et al. (2000) Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence. J. Biol. Chem. 275 24590-4 PubMed GONUTS page

[PMID:22457824-8] Canals, M et al. (2012) Ubiquitination of CXCR7 controls receptor trafficking. PLoS ONE 7 e34192 PubMed GONUTS page

[PMID:12582207-9] Ahn, S et al. (2003) Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proc. Natl. Acad. Sci. U.S.A. 100 1740-4 PubMed GONUTS page

[PMID:10521508-10] Orsini, MJ et al. (1999) Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J. Biol. Chem. 274 31076-86 PubMed GONUTS page

[PMID:23633677-11] Borroni, EM et al. (2013) β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Sci Signal 6 ra30.1-11, S1-3 PubMed GONUTS page

[PMID:9924018-12] Luttrell, LM et al. (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283 655-61 PubMed GONUTS page

[PMID:2163110-13] Lohse, MJ et al. (1990) beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science 248 1547-50 PubMed GONUTS page

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HUMAN:ARRB1

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