HUMAN:ANXA2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ANXA2 (synonyms: ANX2, ANX2L4, CAL1H, LPC2D)
Protein Name(s)	Annexin A2 Annexin II Annexin-2 Calpactin I heavy chain Calpactin-1 heavy chain Chromobindin-8 Lipocortin II Placental anticoagulant protein IV PAP-IV Protein I p36
External Links
UniProt	P07355
EMBL	D00017 BT007432 BX640598 AC087385 BC001388 BC009564 BC015834 BC016774 BC021114 BC023990 BC052558 BC052567 BC066955 BC068065 BC093056
CCDS	CCDS10175.1 CCDS32256.1
PIR	A23942
RefSeq	NP_001002857.1 NP_001002858.1 NP_001129487.1 NP_004030.1
UniGene	Hs.511605
PDB	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4HRH
PDBsum	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4HRH
ProteinModelPortal	P07355
SMR	P07355
BioGrid	106799
IntAct	P07355
MINT	MINT-1213203
STRING	9606.ENSP00000346032
ChEMBL	CHEMBL2111435
DrugBank	DB00031
TCDB	1.A.31.1.4
PhosphoSite	P07355
DMDM	113950
DOSAC-COBS-2DPAGE	P07355
REPRODUCTION-2DPAGE	IPI00455315 P07355
UCD-2DPAGE	P07355
MaxQB	P07355
PaxDb	P07355
PRIDE	P07355
DNASU	302
Ensembl	ENST00000332680 ENST00000396024 ENST00000421017 ENST00000451270
GeneID	302
KEGG	hsa:302
UCSC	uc002agk.3 uc002agm.3
CTD	302
GeneCards	GC15M060639
HGNC	HGNC:537
HPA	CAB004311 HPA046964
MIM	151740
neXtProt	NX_P07355
PharmGKB	PA24827
eggNOG	NOG259189
GeneTree	ENSGT00760000118972
HOGENOM	HOG000158803
HOVERGEN	HBG061815
InParanoid	P07355
KO	K17092
OMA	FIQQDTK
OrthoDB	EOG74XS72
TreeFam	TF105452
Reactome	REACT_267716 REACT_641
ChiTaRS	ANXA2
EvolutionaryTrace	P07355
GeneWiki	Annexin_A2
GenomeRNAi	302
NextBio	1217
PRO	PR:P07355
Proteomes	UP000005640
Bgee	P07355
CleanEx	HS_ANXA2
ExpressionAtlas	P07355
Genevestigator	P07355
GO	GO:0005604 GO:0005938 GO:0009986 GO:0005769 GO:0005768 GO:0005615 GO:0070062 GO:0019897 GO:0031902 GO:0005811 GO:0005765 GO:0044354 GO:0042470 GO:0016020 GO:0030496 GO:0035749 GO:0005634 GO:0048471 GO:0005886 GO:0043234 GO:0001726 GO:0042383 GO:0043220 GO:0031982 GO:0005509 GO:0005544 GO:0048306 GO:0005546 GO:0019834 GO:0044822 GO:0044548 GO:0001525 GO:0007589 GO:0071229 GO:0030199 GO:0042730 GO:0006900 GO:0001765 GO:0043086 GO:0036035 GO:0051099 GO:0048146 GO:0001934 GO:0031340 GO:0051290 GO:0072661
Gene3D	1.10.220.10
InterPro	IPR001464 IPR018502 IPR018252 IPR002389
PANTHER	PTHR10502:SF18
Pfam	PF00191
PRINTS	PR00196 PR00198
SMART	SM00335
PROSITE	PS00223

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016310	phosphorylation	PMID:18990701^[1]	ECO:0000315			P		Fig.1A,C	complete
	GO:0005829	cytosol	PMID:18990701^[1]	ECO:0000315			C		Fig.2A,C	complete
	GO:0005769	early endosome	PMID:18990701^[1]	ECO:0000315			C		Fig.2A,B,4	complete
	GO:0016020	membrane	PMID:18990701^[1]	ECO:0000315			C		Fig.2C	complete
	GO:0008289	lipid binding	PMID:18990701^[1]	ECO:0000315			F		Fig.5A-D	complete
	GO:0003779	actin binding	PMID:18990701^[1]	ECO:0000315			F		Figure S2	complete
	GO:0045022	early endosome to late endosome transport	PMID:18990701^[1]	ECO:0000315			P		Fig.6	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002540)\|part_of:(CL:0002570)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)\|part_of:(UBERON:0001911)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:21645192^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21645192^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
involved_in	GO:1905597	positive regulation of low-density lipoprotein particle receptor binding	PMID:22848640^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0002107) part_of:(GO:1905599) part_of:(GO:0001921) part_of:(GO:0032804) part_of:(GO:1905597) part_of:(GO:1905602)	Seeded From UniProt	complete
involved_in	GO:0001921	positive regulation of receptor recycling	PMID:22848640^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transport_of:(UniProtKB:P01130) part_of:(GO:0032804) part_of:(GO:1905599) part_of:(GO:1905597) part_of:(GO:1905581) part_of:(GO:1905602)	Seeded From UniProt	complete
enables	GO:0098641	cadherin binding involved in cell-cell adhesion	PMID:25468996^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:25468996^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:22848640^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8NBP7	F	part_of:(GO:0032804) part_of:(GO:0001921) part_of:(GO:1900122) part_of:(GO:2000273)	Seeded From UniProt	complete
involved_in	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	PMID:22848640^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0032385) has_direct_input:(GO:0034362) part_of:(GO:1905581) part_of:(GO:1905599) part_of:(GO:1905597) part_of:(GO:0001921)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:1905581	positive regulation of low-density lipoprotein particle clearance	PMID:22848640^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0002107) part_of:(GO:0032804) part_of:(GO:0001921) part_of:(GO:1905599) has_regulation_target:(GO:0034362) part_of:(GO:1905597) part_of:(GO:1905602)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25139904^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:25139904^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044090	positive regulation of vacuole organization	PMID:25139904^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27559042^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0006618) part_of:(UBERON:0002302)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:26812398^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0052405	negative regulation by host of symbiont molecular function	PMID:26812398^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0052362	catabolism by host of symbiont protein	PMID:26812398^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P15363)	Seeded From UniProt	complete
involved_in	GO:0044147	negative regulation of development of symbiont involved in interaction with host	PMID:26812398^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	PMID:22848640^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transport_of:(UniProtKB:P01130) regulates_o_occurs_in:(UBERON:0002107) part_of:(GO:0001921) part_of:(GO:1905597) part_of:(GO:1905599) part_of:(GO:1905602) part_of:(GO:1905581)	Seeded From UniProt	complete
part_of	GO:1990667	PCSK9-AnxA2 complex	PMID:22848640^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0098772	molecular function regulator	PMID:22848640^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P01130)	Seeded From UniProt	complete
involved_in	GO:1905599	positive regulation of low-density lipoprotein receptor activity	PMID:22848640^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0002369) part_of:(GO:0001921) part_of:(GO:0032804) regulates_transport_of:(GO:0034362) part_of:(GO:1905599) part_of:(GO:1905597) part_of:(GO:1905602)\|regulates_o_occurs_in(UBERON:0001155) part_of:(GO:0001921) part_of:(GO:0032804) regulates_transport_of:(GO:0034362) part_of:(GO:1905599) part_of:(GO:1905597) part_of:(GO:1905602)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07356	C	part_of:(CL:0000212) part_of:(UBERON:0002116)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:19190083^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002202)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18799458^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:18767904^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[16]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:22057634^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002372)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[18]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[19]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[20]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	PMID:23861394^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P60903)	Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	PMID:23091277^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P60903)	Seeded From UniProt	complete
colocalizes_with	GO:0045121	membrane raft	PMID:14699089^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044548	S100 protein binding	PMID:14699089^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60903	F		Seeded From UniProt	complete
enables	GO:0044548	S100 protein binding	PMID:23091277^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60903	F		Seeded From UniProt	complete
involved_in	GO:0036035	osteoclast development	PMID:7961821^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	PMID:23360953^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	PMID:3013422^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:10809787^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0006900	vesicle budding from membrane	PMID:23861394^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:23360953^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[28]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22664934^[29]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PMID:23861394^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001765	membrane raft assembly	PMID:23861394^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:15226301^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01023	F	inhibited_by:(CHEBI:60888)	Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:22261194^[31]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19620	C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:21362503^[32]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002367)	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[33]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	PMID:2138016^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:15166316^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:14741744^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:2138016^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:11866539^[37]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:1905599	positive regulation of low-density lipoprotein receptor activity	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:1905597	positive regulation of low-density lipoprotein particle receptor binding	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:1905581	positive regulation of low-density lipoprotein particle clearance	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:1903902	positive regulation of viral life cycle	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P19620	P		Seeded From UniProt	complete
enables	GO:0099511	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P17785	F		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 RGD:621170	P		Seeded From UniProt	complete
involved_in	GO:0060956	endocardial cell differentiation	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P17785	P		Seeded From UniProt	complete
involved_in	GO:0052405	negative regulation by host of symbiont molecular function	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:0052362	catabolism by host of symbiont protein	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P17785	P		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 RGD:621170	P		Seeded From UniProt	complete
enables	GO:0046790	virion binding	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P17785	F		Seeded From UniProt	complete
involved_in	GO:0044794	positive regulation by host of viral process	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P19620	P		Seeded From UniProt	complete
enables	GO:0044730	bone sialoprotein binding	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 RGD:621170	F		Seeded From UniProt	complete
enables	GO:0044548	S100 protein binding	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355 UniProtKB:P19620	F		Seeded From UniProt	complete
involved_in	GO:0044147	negative regulation of development of symbiont involved in interaction with host	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:0044090	positive regulation of vacuole organization	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	F		Seeded From UniProt	complete
involved_in	GO:0042730	fibrinolysis	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598	P		Seeded From UniProt	complete
involved_in	GO:0036035	osteoclast development	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P17785	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598 RGD:621170 UniProtKB:P04272 UniProtKB:P07355 UniProtKB:P17785 UniProtKB:Q6TEQ7	C		Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:0031214	biomineral tissue development	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P04272	P		Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598	P		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	F		Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 RGD:621170	F		Seeded From UniProt	complete
involved_in	GO:0010755	regulation of plasminogen activation	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P17785	P		Seeded From UniProt	complete
involved_in	GO:0006900	vesicle budding from membrane	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598 RGD:621170 UniProtKB:P07355 UniProtKB:P17785	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598 RGD:621170 UniProtKB:P04272 UniProtKB:P07355 UniProtKB:Q6TEQ7	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P04272	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	C		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 RGD:621170 UniProtKB:P07355	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P04272	F		Seeded From UniProt	complete
involved_in	GO:0003417	growth plate cartilage development	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P17785	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 RGD:621170	P		Seeded From UniProt	complete
involved_in	GO:0001921	positive regulation of receptor recycling	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P04272	F		Seeded From UniProt	complete
involved_in	GO:0001765	membrane raft assembly	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21873635^[38]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88246 PANTHER:PTN000052598 UniProtKB:P07355	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26812398^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07355	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18799458^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07355	F		Seeded From UniProt	complete
involved_in	GO:0043086	negative regulation of catalytic activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004859	P		Seeded From UniProt	complete
involved_in	GO:0043086	negative regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019834	P		Seeded From UniProt	complete
involved_in	GO:0043086	negative regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019834	P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099511	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005262	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098641	P		Seeded From UniProt	complete
involved_in	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	P		Seeded From UniProt	complete
involved_in	GO:1905599	positive regulation of low-density lipoprotein receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	P		Seeded From UniProt	complete
involved_in	GO:1905597	positive regulation of low-density lipoprotein particle receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	P		Seeded From UniProt	complete
involved_in	GO:1905581	positive regulation of low-density lipoprotein particle clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	P		Seeded From UniProt	complete
involved_in	GO:0051099	positive regulation of binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	P		Seeded From UniProt	complete
part_of	GO:0043220	Schmidt-Lanterman incisure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	C		Seeded From UniProt	complete
involved_in	GO:0042730	fibrinolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	C		Seeded From UniProt	complete
part_of	GO:0035749	myelin sheath adaxonal region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	C		Seeded From UniProt	complete
involved_in	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	P		Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	P		Seeded From UniProt	complete
part_of	GO:0019897	extrinsic component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	C		Seeded From UniProt	complete
involved_in	GO:0001921	positive regulation of receptor recycling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07356 ensembl:ENSMUSP00000034756	P		Seeded From UniProt	complete
involved_in	GO:0097066	response to thyroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
enables	GO:0044730	bone sialoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	F		Seeded From UniProt	complete
part_of	GO:0044354	macropinosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
involved_in	GO:0007589	body fluid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	P		Seeded From UniProt	complete
part_of	GO:0001726	ruffle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07936 ensembl:ENSRNOP00000038428	C		Seeded From UniProt	complete
enables	GO:0004859	phospholipase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002389	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001464 InterPro:IPR002389 InterPro:IPR018252 InterPro:IPR018502 InterPro:IPR037104	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001464 InterPro:IPR002389 InterPro:IPR018252 InterPro:IPR018502 InterPro:IPR037104	F		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002389	F		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035722	interleukin-12-mediated signaling pathway	Reactome:R-HSA-9020591	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035578	azurophil granule lumen	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8950480 Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0111	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0084 UniProtKB-SubCell:SL-0025	C		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Morel, E & Gruenberg, J (2009) Annexin A2 binding to endosomes and functions in endosomal transport are regulated by tyrosine 23 phosphorylation. J. Biol. Chem. 284 1604-11 PubMed GONUTS page
↑ Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ ^4.0 ^4.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ ^5.0 ^5.1 Urbanska, A et al. (2011) Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment. Traffic 12 1227-41 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Seidah, NG et al. (2012) Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PLoS ONE 7 e41865 PubMed GONUTS page
↑ ^7.0 ^7.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Somarajan, SR et al. (2014) Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells. MBio 5 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Yuan, S et al. (2016) N-Terminal Polypeptide of Annexin A2 Decreases Infection of Mycoplasma hyorhinis to Gastric Cancer Cells. PLoS ONE 11 e0147776 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page
↑ ^14.0 ^14.1 Mayer, G et al. (2008) Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. J. Biol. Chem. 283 31791-801 PubMed GONUTS page
↑ Pons, V et al. (2008) Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 6 e214 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Zacharias, U et al. (2011) Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release. J. Muscle Res. Cell. Motil. 32 271-80 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Drücker, P et al. (2013) Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2. J. Biol. Chem. 288 24764-76 PubMed GONUTS page
↑ ^22.0 ^22.1 Nazmi, AR et al. (2012) N-terminal acetylation of annexin A2 is required for S100A10 binding. Biol. Chem. 393 1141-50 PubMed GONUTS page
↑ ^23.0 ^23.1 Benaud, C et al. (2004) AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture. J. Cell Biol. 164 133-44 PubMed GONUTS page
↑ Takahashi, S et al. (1994) Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. J. Biol. Chem. 269 28696-701 PubMed GONUTS page
↑ ^25.0 ^25.1 Domon, MM et al. (2013) Interaction of AnxA6 with isolated and artificial lipid microdomains; importance of lipid composition and calcium content. Mol Biosyst 9 668-76 PubMed GONUTS page
↑ Huang, KS et al. (1986) Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase. Cell 46 191-9 PubMed GONUTS page
↑ Ma, K et al. (2000) High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. J. Biol. Chem. 275 15541-8 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
↑ Ling, TY et al. (2004) Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. J. Biol. Chem. 279 38736-48 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
↑ Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^34.0 ^34.1 Blackwood, RA & Ernst, JD (1990) Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Biochem. J. 266 195-200 PubMed GONUTS page
↑ Skop, AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305 61-6 PubMed GONUTS page
↑ Fujimoto, Y et al. (2004) Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim. Biophys. Acta 1644 47-59 PubMed GONUTS page
↑ Aitkenhead, M et al. (2002) Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc. Res. 63 159-71 PubMed GONUTS page
↑ ^38.00 ^38.01 ^38.02 ^38.03 ^38.04 ^38.05 ^38.06 ^38.07 ^38.08 ^38.09 ^38.10 ^38.11 ^38.12 ^38.13 ^38.14 ^38.15 ^38.16 ^38.17 ^38.18 ^38.19 ^38.20 ^38.21 ^38.22 ^38.23 ^38.24 ^38.25 ^38.26 ^38.27 ^38.28 ^38.29 ^38.30 ^38.31 ^38.32 ^38.33 ^38.34 ^38.35 ^38.36 ^38.37 ^38.38 ^38.39 ^38.40 ^38.41 ^38.42 ^38.43 ^38.44 ^38.45 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18990701-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Morel, E & Gruenberg, J (2009) Annexin A2 binding to endosomes and functions in endosomal transport are regulated by tyrosine 23 phosphorylation. J. Biol. Chem. 284 1604-11 PubMed GONUTS page

[PMID:28327460-2] Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:28675934-3] Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:25037231-4] 4.0 ^4.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:21645192-5] 5.0 ^5.1 Urbanska, A et al. (2011) Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment. Traffic 12 1227-41 PubMed GONUTS page

[PMID:22848640-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Seidah, NG et al. (2012) Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PLoS ONE 7 e41865 PubMed GONUTS page

[PMID:25468996-7] 7.0 ^7.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:27068509-8] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:25139904-9] 9.0 ^9.1 ^9.2 Somarajan, SR et al. (2014) Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells. MBio 5 PubMed GONUTS page

[PMID:27559042-10] Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page

[PMID:26812398-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Yuan, S et al. (2016) N-Terminal Polypeptide of Annexin A2 Decreases Infection of Mycoplasma hyorhinis to Gastric Cancer Cells. PLoS ONE 11 e0147776 PubMed GONUTS page

[PMID:23533145-12] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19190083-13] Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page

[PMID:18799458-14] 14.0 ^14.1 Mayer, G et al. (2008) Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. J. Biol. Chem. 283 31791-801 PubMed GONUTS page

[PMID:18767904-15] Pons, V et al. (2008) Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 6 e214 PubMed GONUTS page

[PMID:19946888-16] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:22057634-17] Zacharias, U et al. (2011) Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release. J. Muscle Res. Cell. Motil. 32 271-80 PubMed GONUTS page

[PMID:19199708-18] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-19] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-20] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:23861394-21] 21.0 ^21.1 ^21.2 ^21.3 Drücker, P et al. (2013) Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2. J. Biol. Chem. 288 24764-76 PubMed GONUTS page

[PMID:23091277-22] 22.0 ^22.1 Nazmi, AR et al. (2012) N-terminal acetylation of annexin A2 is required for S100A10 binding. Biol. Chem. 393 1141-50 PubMed GONUTS page

[PMID:14699089-23] 23.0 ^23.1 Benaud, C et al. (2004) AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture. J. Cell Biol. 164 133-44 PubMed GONUTS page

[PMID:7961821-24] Takahashi, S et al. (1994) Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. J. Biol. Chem. 269 28696-701 PubMed GONUTS page

[PMID:23360953-25] 25.0 ^25.1 Domon, MM et al. (2013) Interaction of AnxA6 with isolated and artificial lipid microdomains; importance of lipid composition and calcium content. Mol Biosyst 9 668-76 PubMed GONUTS page

[PMID:3013422-26] Huang, KS et al. (1986) Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase. Cell 46 191-9 PubMed GONUTS page

[PMID:10809787-27] Ma, K et al. (2000) High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. J. Biol. Chem. 275 15541-8 PubMed GONUTS page

[PMID:21630459-28] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:22664934-29] Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page

[PMID:15226301-30] Ling, TY et al. (2004) Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. J. Biol. Chem. 279 38736-48 PubMed GONUTS page

[PMID:22261194-31] Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page

[PMID:21362503-32] Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page

[PMID:22658674-33] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:2138016-34] 34.0 ^34.1 Blackwood, RA & Ernst, JD (1990) Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Biochem. J. 266 195-200 PubMed GONUTS page

[PMID:15166316-35] Skop, AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305 61-6 PubMed GONUTS page

[PMID:14741744-36] Fujimoto, Y et al. (2004) Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim. Biophys. Acta 1644 47-59 PubMed GONUTS page

[PMID:11866539-37] Aitkenhead, M et al. (2002) Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc. Res. 63 159-71 PubMed GONUTS page

[PMID:21873635-38] 38.00 ^38.01 ^38.02 ^38.03 ^38.04 ^38.05 ^38.06 ^38.07 ^38.08 ^38.09 ^38.10 ^38.11 ^38.12 ^38.13 ^38.14 ^38.15 ^38.16 ^38.17 ^38.18 ^38.19 ^38.20 ^38.21 ^38.22 ^38.23 ^38.24 ^38.25 ^38.26 ^38.27 ^38.28 ^38.29 ^38.30 ^38.31 ^38.32 ^38.33 ^38.34 ^38.35 ^38.36 ^38.37 ^38.38 ^38.39 ^38.40 ^38.41 ^38.42 ^38.43 ^38.44 ^38.45 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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