HUMAN:AIF1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AIF1 (synonyms: G1, IBA1)
Protein Name(s)	Allograft inflammatory factor 1 AIF-1 Ionized calcium-binding adapter molecule 1 Protein G1
External Links
UniProt	P55008
EMBL	U49392 U95213 U19713 Y14768 Y14768 Y14768 D86438 AF299327 EF070982 AK290771 CR542153 AF129756 BA000025 AL662847 AL805934 AL662801 AL805934 CR753892 CR759761 BX248305 CH471081 CH471081 BC009474
CCDS	CCDS4706.1
PIR	JC5246
RefSeq	NP_001614.3 NP_004838.1 NP_116573.1
UniGene	Hs.76364
PDB	2D58 2G2B
PDBsum	2D58 2G2B
ProteinModelPortal	P55008
SMR	P55008
BioGrid	106702
IntAct	P55008
STRING	9606.ENSP00000393996
PhosphoSite	P55008
DMDM	1703217
MaxQB	P55008
PaxDb	P55008
PRIDE	P55008
DNASU	199
Ensembl	ENST00000376049 ENST00000376059 ENST00000383473 ENST00000383474 ENST00000413349 ENST00000414149 ENST00000415830 ENST00000416422 ENST00000419376 ENST00000424944 ENST00000425748 ENST00000440907
GeneID	199
KEGG	hsa:199
UCSC	uc003nuy.3 uc010jsy.3
CTD	199
GeneCards	GC06P031582 GC06Pj31570 GC06Pk31565 GC06Pm31659 GC06Pn31573 GC06Po31572
HGNC	HGNC:352
HPA	HPA049234
MIM	601833
neXtProt	NX_P55008
PharmGKB	PA24646
eggNOG	NOG262998
GeneTree	ENSGT00390000013846
HOGENOM	HOG000231928
HOVERGEN	HBG004002
InParanoid	P55008
KO	K18617
OrthoDB	EOG73FQPC
PhylomeDB	P55008
TreeFam	TF320736
ChiTaRS	AIF1
EvolutionaryTrace	P55008
GeneWiki	AIF1
GenomeRNAi	199
NextBio	796
PRO	PR:P55008
Proteomes	UP000005640 UP000005640
Bgee	P55008
CleanEx	HS_AIF1
ExpressionAtlas	P55008
Genevestigator	P55008
GO	GO:0005884 GO:0005737 GO:0005829 GO:0030027 GO:0005634 GO:0043204 GO:0048471 GO:0001891 GO:0032587 GO:0051015 GO:0005509 GO:0051017 GO:0030041 GO:0031668 GO:0032870 GO:0071447 GO:0071346 GO:0071315 GO:0006954 GO:0001774 GO:0043066 GO:0010629 GO:0071672 GO:0048662 GO:0006911 GO:1900087 GO:0090026 GO:0014739 GO:0045429 GO:0001934 GO:0071673 GO:0048661 GO:2000406 GO:0042102 GO:0016601 GO:0048678 GO:0051602 GO:0097178
Gene3D	1.10.238.10
InterPro	IPR011992 IPR002048
PROSITE	PS50222

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0090271	positive regulation of fibroblast growth factor production	PMID:19745784^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P09038)	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:19745784^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	PMID:19745784^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:19745784^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	C	part_of:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	C	part_of:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0001726	ruffle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	C	part_of:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:12887599^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12887599^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0051764	actin crosslink formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	P		Seeded From UniProt	complete
involved_in	GO:0030046	parallel actin filament bundle assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	P		Seeded From UniProt	complete
involved_in	GO:0050921	positive regulation of chemotaxis	PMID:24796669^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:2000001) regulates_o_occurs_in:(CL:2000001) part_of:(GO:0071677)	Seeded From UniProt	complete
involved_in	GO:0071677	positive regulation of mononuclear cell migration	PMID:24796669^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:2000001) regulates_o_occurs_in:(CL:2000001)	Seeded From UniProt	complete
involved_in	GO:0090197	positive regulation of chemokine secretion	PMID:24796669^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:2000001) regulates_o_occurs_in:(CL:2000001) has_regulation_target:(UniProtKB:P10147)	Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	PMID:24796669^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:2000001) regulates_o_occurs_in:(CL:2000001)	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:24796669^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P	occurs_in:(CL:2000001) regulates_o_occurs_in:(CL:2000001)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:28601280^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000129) part_of:(UBERON:0002316)\|part_of:(CL:0000129) part_of:(UBERON:0002020)	Seeded From UniProt	complete
involved_in	GO:2000406	positive regulation of T cell migration	PMID:16049345^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	PMID:15117732^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	PMID:11557666^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:0097178	ruffle assembly	PMID:17011575^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097178	ruffle assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	P		Seeded From UniProt	complete
involved_in	GO:0090026	positive regulation of monocyte chemotaxis	PMID:15117732^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071673	positive regulation of smooth muscle cell chemotaxis	PMID:22116621^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:0071672	negative regulation of smooth muscle cell chemotaxis	PMID:22116621^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	PMID:9614071^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55009	P		Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	PMID:18699778^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:16049345^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:18699778^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:22116621^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:9614071^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359) occurs_in:(UBERON:0001621)	Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:22116621^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:15117732^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:9614071^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:16049345^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0032587	ruffle membrane	PMID:18699778^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030041	actin filament polymerization	PMID:16049345^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	C		Seeded From UniProt	complete
involved_in	GO:0016601	Rac protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:7769138^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55009	P		Seeded From UniProt	complete
involved_in	GO:0006911	phagocytosis, engulfment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	P		Seeded From UniProt	complete
colocalizes_with	GO:0005884	actin filament	PMID:18699778^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22116621^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22116621^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:17011575^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	F		Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70200	C		Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	PMID:17011575^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097178	ruffle assembly	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1343098 PANTHER:PTN000039781	P		Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1343098 PANTHER:PTN000039781 UniProtKB:P55008	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000039781 UniProtKB:P55008 UniProtKB:Q9BQI0	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000039781 RGD:61924	C		Seeded From UniProt	complete
colocalizes_with	GO:0032587	ruffle membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1343098 PANTHER:PTN000039781 UniProtKB:P55008	C		Seeded From UniProt	complete
colocalizes_with	GO:0005884	actin filament	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1343098 PANTHER:PTN000039781 UniProtKB:P55008 UniProtKB:Q9BQI0	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1343098 PANTHER:PTN000039781	F		Seeded From UniProt	complete
involved_in	GO:0097178	ruffle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	P		Seeded From UniProt	complete
involved_in	GO:0051764	actin crosslink formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	P		Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	F		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	C		Seeded From UniProt	complete
involved_in	GO:0030046	parallel actin filament bundle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	C		Seeded From UniProt	complete
involved_in	GO:0016601	Rac protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	P		Seeded From UniProt	complete
involved_in	GO:0006911	phagocytosis, engulfment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	P		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	F		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	C		Seeded From UniProt	complete
part_of	GO:0001726	ruffle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70200 ensembl:ENSMUSP00000133709	C		Seeded From UniProt	complete
involved_in	GO:0071447	cellular response to hydroperoxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0071315	cellular response to morphine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	C		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0032870	cellular response to hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0031668	cellular response to extracellular stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	C		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0014739	positive regulation of muscle hyperplasia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	C		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55009 ensembl:ENSRNOP00000001135	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0473	C		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0301	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Jia, J et al. (2010) Overexpression of allograft inflammatory factor-1 promotes the proliferation and migration of human endothelial cells (HUV-EC-C) probably by up-regulation of basic fibroblast growth factor. Pediatr. Res. 67 29-34 PubMed GONUTS page
↑ ^2.0 ^2.1 Deininger, MH et al. (2003) The allograft inflammatory factor-1 in Creutzfeldt-Jakob disease brains. Neuropathol. Appl. Neurobiol. 29 389-99 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kadoya, M et al. (2014) Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 448 287-91 PubMed GONUTS page
↑ Hendrickx, DAE et al. (2017) Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. J. Neuroimmunol. 309 12-22 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kelemen, SE & Autieri, MV (2005) Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies. Am. J. Pathol. 167 619-26 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Chen, X et al. (2004) AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF. Arterioscler. Thromb. Vasc. Biol. 24 1217-22 PubMed GONUTS page
↑ Autieri, MV & Carbone, CM (2001) Overexpression of allograft inflammatory factor-1 promotes proliferation of vascular smooth muscle cells by cell cycle deregulation. Arterioscler. Thromb. Vasc. Biol. 21 1421-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Yamada, M et al. (2006) X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding. J. Mol. Biol. 364 449-57 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Berglund, LM et al. (2012) NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis. Cardiovasc. Res. 93 414-23 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Autieri, MV & Agrawal, N (1998) IRT-1, a novel interferon-gamma-responsive transcript encoding a growth-suppressing basic leucine zipper protein. J. Biol. Chem. 273 14731-7 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Schulze, JO et al. (2008) Structural and functional characterization of human Iba proteins. FEBS J. 275 4627-40 PubMed GONUTS page
↑ Utans, U et al. (1995) Cloning and characterization of allograft inflammatory factor-1: a novel macrophage factor identified in rat cardiac allografts with chronic rejection. J. Clin. Invest. 95 2954-62 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19745784-1] 1.0 ^1.1 ^1.2 ^1.3 Jia, J et al. (2010) Overexpression of allograft inflammatory factor-1 promotes the proliferation and migration of human endothelial cells (HUV-EC-C) probably by up-regulation of basic fibroblast growth factor. Pediatr. Res. 67 29-34 PubMed GONUTS page

[PMID:12887599-2] 2.0 ^2.1 Deininger, MH et al. (2003) The allograft inflammatory factor-1 in Creutzfeldt-Jakob disease brains. Neuropathol. Appl. Neurobiol. 29 389-99 PubMed GONUTS page

[PMID:24796669-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kadoya, M et al. (2014) Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 448 287-91 PubMed GONUTS page

[PMID:28601280-4] Hendrickx, DAE et al. (2017) Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. J. Neuroimmunol. 309 12-22 PubMed GONUTS page

[PMID:16049345-5] 5.0 ^5.1 ^5.2 ^5.3 Kelemen, SE & Autieri, MV (2005) Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies. Am. J. Pathol. 167 619-26 PubMed GONUTS page

[PMID:15117732-6] 6.0 ^6.1 ^6.2 Chen, X et al. (2004) AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF. Arterioscler. Thromb. Vasc. Biol. 24 1217-22 PubMed GONUTS page

[PMID:11557666-7] Autieri, MV & Carbone, CM (2001) Overexpression of allograft inflammatory factor-1 promotes proliferation of vascular smooth muscle cells by cell cycle deregulation. Arterioscler. Thromb. Vasc. Biol. 21 1421-6 PubMed GONUTS page

[PMID:17011575-8] 8.0 ^8.1 ^8.2 Yamada, M et al. (2006) X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding. J. Mol. Biol. 364 449-57 PubMed GONUTS page

[PMID:22116621-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Berglund, LM et al. (2012) NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis. Cardiovasc. Res. 93 414-23 PubMed GONUTS page

[PMID:9614071-10] 10.0 ^10.1 ^10.2 Autieri, MV & Agrawal, N (1998) IRT-1, a novel interferon-gamma-responsive transcript encoding a growth-suppressing basic leucine zipper protein. J. Biol. Chem. 273 14731-7 PubMed GONUTS page

[PMID:18699778-11] 11.0 ^11.1 ^11.2 ^11.3 Schulze, JO et al. (2008) Structural and functional characterization of human Iba proteins. FEBS J. 275 4627-40 PubMed GONUTS page

[PMID:7769138-12] Utans, U et al. (1995) Cloning and characterization of allograft inflammatory factor-1: a novel macrophage factor identified in rat cardiac allografts with chronic rejection. J. Clin. Invest. 95 2954-62 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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