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PMID:22116621

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Citation

Berglund, LM, Kotova, O, Osmark, P, Grufman, H, Xing, C, Lydrup, ML, Goncalves, I, Autieri, MV and Gomez, MF (2012) NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis. Cardiovasc. Res. 93:414-23

Abstract

Alternative transcription and splicing of the allograft inflammatory factor-1 (AIF-1) gene results in the expression of two different proteins: AIF-1 and interferon responsive transcript-1 (IRT-1).  Here, we explore the impact of AIF-1 and IRT-1 on vascular smooth muscle cell (VSMC) activation and neointima formation, the mechanisms underlying their alternative splicing, and associations of AIF-1 and IRT-1 mRNA with parameters defining human atherosclerotic plaque phenotype.

Links

PubMed PMC3410428 Online version:10.1093/cvr/cvr309

Keywords

Alternative Splicing/physiology; Angioplasty, Balloon, Coronary/adverse effects; Animals; Carotid Arteries/pathology; Carotid Artery Diseases/genetics; Carotid Artery Diseases/metabolism; Carotid Artery Diseases/pathology; Carotid Artery Injuries/metabolism; Carotid Artery Injuries/pathology; Coronary Artery Disease/genetics; Coronary Artery Disease/metabolism; Coronary Artery Disease/pathology; Coronary Restenosis/metabolism; Coronary Restenosis/pathology; Coronary Vessels/pathology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Disease Models, Animal; Female; Humans; Male; Muscle, Smooth, Vascular/pathology; Myometrium/blood supply; NFATC Transcription Factors/metabolism; Neointima/genetics; Neointima/metabolism; Neointima/pathology; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Signal Transduction/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:AIF1

involved_in

GO:0048662: negative regulation of smooth muscle cell proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000359)

Seeded From UniProt

complete

HUMAN:AIF1

involved_in

GO:0048661: positive regulation of smooth muscle cell proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000359)

Seeded From UniProt

complete

HUMAN:AIF1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:AIF1

located_in

GO:0005829: cytosol

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:AIF1

involved_in

GO:0071673: positive regulation of smooth muscle cell chemotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000359)

Seeded From UniProt

complete

HUMAN:AIF1

involved_in

GO:0071672: negative regulation of smooth muscle cell chemotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000359)

Seeded From UniProt

complete

HUMAN:AIF1

involved_in

GO:0071673: positive regulation of smooth muscle cell chemotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

occurs_in:(CL:0000359)

Seeded From UniProt

complete

HUMAN:AIF1

involved_in

GO:0071672: negative regulation of smooth muscle cell chemotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

occurs_in:(CL:0000359)

Seeded From UniProt

complete

HUMAN:AIF1

involved_in

GO:0048662: negative regulation of smooth muscle cell proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

occurs_in:(CL:0000359)

Seeded From UniProt

complete

HUMAN:AIF1

involved_in

GO:0048661: positive regulation of smooth muscle cell proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

occurs_in:(CL:0000359)

Seeded From UniProt

complete

HUMAN:AIF1

part_of

GO:0005829: cytosol

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:AIF1

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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