PMID:22116621

Citation	Berglund, LM, Kotova, O, Osmark, P, Grufman, H, Xing, C, Lydrup, ML, Goncalves, I, Autieri, MV and Gomez, MF (2012) NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis. Cardiovasc. Res. 93:414-23
Abstract	Alternative transcription and splicing of the allograft inflammatory factor-1 (AIF-1) gene results in the expression of two different proteins: AIF-1 and interferon responsive transcript-1 (IRT-1).  Here, we explore the impact of AIF-1 and IRT-1 on vascular smooth muscle cell (VSMC) activation and neointima formation, the mechanisms underlying their alternative splicing, and associations of AIF-1 and IRT-1 mRNA with parameters defining human atherosclerotic plaque phenotype.
Links	PubMed PMC3410428 Online version:10.1093/cvr/cvr309
Keywords	Alternative Splicing/physiology; Angioplasty, Balloon, Coronary/adverse effects; Animals; Carotid Arteries/pathology; Carotid Artery Diseases/genetics; Carotid Artery Diseases/metabolism; Carotid Artery Diseases/pathology; Carotid Artery Injuries/metabolism; Carotid Artery Injuries/pathology; Coronary Artery Disease/genetics; Coronary Artery Disease/metabolism; Coronary Artery Disease/pathology; Coronary Restenosis/metabolism; Coronary Restenosis/pathology; Coronary Vessels/pathology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Disease Models, Animal; Female; Humans; Male; Muscle, Smooth, Vascular/pathology; Myometrium/blood supply; NFATC Transcription Factors/metabolism; Neointima/genetics; Neointima/metabolism; Neointima/pathology; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Signal Transduction/physiology
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:AIF1	involved_in	GO:0048662: negative regulation of smooth muscle cell proliferation	ECO:0000314: direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
HUMAN:AIF1	involved_in	GO:0048661: positive regulation of smooth muscle cell proliferation	ECO:0000314: direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
HUMAN:AIF1	located_in	GO:0005634: nucleus	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
HUMAN:AIF1	located_in	GO:0005829: cytosol	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
HUMAN:AIF1	involved_in	GO:0071673: positive regulation of smooth muscle cell chemotaxis	ECO:0000314: direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
HUMAN:AIF1	involved_in	GO:0071672: negative regulation of smooth muscle cell chemotaxis	ECO:0000314: direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
HUMAN:AIF1	involved_in	GO:0071673: positive regulation of smooth muscle cell chemotaxis	ECO:0000314: direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
HUMAN:AIF1	involved_in	GO:0071672: negative regulation of smooth muscle cell chemotaxis	ECO:0000314: direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
HUMAN:AIF1	involved_in	GO:0048662: negative regulation of smooth muscle cell proliferation	ECO:0000314: direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
HUMAN:AIF1	involved_in	GO:0048661: positive regulation of smooth muscle cell proliferation	ECO:0000314: direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
HUMAN:AIF1	part_of	GO:0005829: cytosol	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
HUMAN:AIF1	part_of	GO:0005634: nucleus	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete

References

See Help:References for how to manage references in GONUTS.