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HUMAN:AF10
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MLLT10 (synonyms: AF10) | |
| Protein Name(s) | Protein AF-10
ALL1-fused gene from chromosome 10 protein | |
| External Links | ||
| UniProt | P55197 | |
| EMBL | U13948 AY598745 AL161799 AL358780 AL359697 AL357372 AL358780 AL161799 AL357372 AL359697 AL358780 AL358780 AL359697 AL357372 AL358780 AL161799 AL357372 AL359697 AL358780 AL161799 BC080577 BC094844 BC129946 | |
| CCDS | CCDS55706.1 CCDS55707.1 CCDS55708.1 CCDS7135.1 | |
| PIR | I38759 | |
| RefSeq | NP_001182555.1 NP_001182556.1 NP_001182557.1 NP_001182559.1 NP_004632.1 XP_005252665.1 | |
| UniGene | Hs.30385 | |
| ProteinModelPortal | P55197 | |
| SMR | P55197 | |
| BioGrid | 113723 | |
| DIP | DIP-37633N | |
| IntAct | P55197 | |
| STRING | 9606.ENSP00000366272 | |
| PhosphoSite | P55197 | |
| DMDM | 527504034 | |
| PaxDb | P55197 | |
| PRIDE | P55197 | |
| DNASU | 8028 | |
| Ensembl | ENST00000307729 ENST00000377059 ENST00000377072 ENST00000377091 ENST00000377100 ENST00000621220 | |
| GeneID | 8028 | |
| KEGG | hsa:8028 | |
| UCSC | uc001iqq.2 uc001iqr.2 uc001iqs.3 uc001iqt.3 | |
| CTD | 8028 | |
| GeneCards | GC10P021825 | |
| HGNC | HGNC:16063 | |
| HPA | HPA005747 | |
| MIM | 602409 | |
| neXtProt | NX_P55197 | |
| Orphanet | 99861 | |
| PharmGKB | PA30849 | |
| eggNOG | COG5141 | |
| GeneTree | ENSGT00740000114866 | |
| HOGENOM | HOG000033831 | |
| HOVERGEN | HBG004186 | |
| InParanoid | P55197 | |
| OMA | KSPHLGN | |
| OrthoDB | EOG7K6PT9 | |
| PhylomeDB | P55197 | |
| TreeFam | TF316118 | |
| ChiTaRS | MLLT10 | |
| GeneWiki | MLLT10 | |
| GenomeRNAi | 8028 | |
| NextBio | 30601 | |
| PRO | PR:P55197 | |
| Proteomes | UP000005640 | |
| Bgee | P55197 | |
| CleanEx | HS_MLLT10 | |
| ExpressionAtlas | P55197 | |
| Genevestigator | P55197 | |
| GO | GO:0005737 GO:0005634 GO:0003677 GO:0003700 GO:0008270 GO:0045944 GO:0006351 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR019786 IPR011011 IPR001965 IPR019787 IPR013083 | |
| SMART | SM00249 | |
| SUPFAM | SSF57903 | |
| PROSITE | PS01359 PS50016 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031491 |
nucleosome binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042393 |
histone binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Chen, S et al. (2015) The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Mol. Cell 60 319-27 PubMed GONUTS page
- ↑ Chaplin, T et al. (1995) A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Blood 85 1435-41 PubMed GONUTS page
- ↑ Forissier, S et al. (2007) AF10-dependent transcription is enhanced by its interaction with FLRG. Biol. Cell 99 563-71 PubMed GONUTS page
- ↑ 4.0 4.1 Okada, Y et al. (2005) hDOT1L links histone methylation to leukemogenesis. Cell 121 167-78 PubMed GONUTS page
