PMID:7888665

Citation	Chaplin, T, Ayton, P, Bernard, OA, Saha, V, Della Valle, V, Hillion, J, Gregorini, A, Lillington, D, Berger, R and Young, BD (1995) A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Blood 85:1435-41
Abstract	A novel class of conserved transcription factors has been identified from the molecular cloning of AF10, the gene involved in the t(10;11)(p12;q23) translocation of acute myeloid leukemias. AF10 encodes a 109-kD protein of 1,027 amino acids and contains an N-terminal zinc finger region and a C-terminal leucine zipper. These structures have been found to be conserved in sequence and position in three other proteins, AF17, BR140, and a previously unrecognized Caenorhabditis elegans gene, provisionally named CEZF. The overall structure, level of sequence conservation, and expression pattern suggest that these genes encode a new class of transcription factors, some of which are targets for chromosomal translocation in acute leukemia.
Links	PubMed
Keywords	Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Base Sequence; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 11; Cloning, Molecular; DNA-Binding Proteins; Humans; Leucine Zippers/genetics; Leukemia, Myeloid, Acute/genetics; Molecular Sequence Data; Neoplasm Proteins/genetics; Nuclear Proteins/genetics; Transcription Factors/genetics; Translocation, Genetic; Zinc Fingers/genetics
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Significance

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:AF10	enables	GO:0003700: DNA-binding transcription factor activity	ECO:0000303: author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete

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