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HUMAN:ACACB
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ACACB (synonyms: ACC2, ACCB) | |
| Protein Name(s) | Acetyl-CoA carboxylase 2
ACC-beta Biotin carboxylase | |
| External Links | ||
| UniProt | O00763 | |
| EMBL | U89344 DQ493870 AJ575431 AJ575592 AY382667 AC007637 U34591 | |
| CCDS | CCDS31898.1 | |
| PIR | S71091 | |
| RefSeq | NP_001084.3 XP_005253933.1 XP_006719428.1 XP_006719430.1 | |
| UniGene | Hs.234898 | |
| PDB | 2DN8 2HJW 2KCC 3FF6 3GID 3GLK 3JRW 3JRX 3TDC 4HQ6 | |
| PDBsum | 2DN8 2HJW 2KCC 3FF6 3GID 3GLK 3JRW 3JRX 3TDC 4HQ6 | |
| ProteinModelPortal | O00763 | |
| SMR | O00763 | |
| BioGrid | 106550 | |
| DIP | DIP-51617N | |
| IntAct | O00763 | |
| MINT | MINT-6800190 | |
| STRING | 9606.ENSP00000367079 | |
| BindingDB | O00763 | |
| ChEMBL | CHEMBL4829 | |
| DrugBank | DB00173 DB00121 | |
| GuidetoPHARMACOLOGY | 1264 | |
| PhosphoSite | O00763 | |
| MaxQB | O00763 | |
| PaxDb | O00763 | |
| PRIDE | O00763 | |
| DNASU | 32 | |
| Ensembl | ENST00000338432 ENST00000377848 | |
| GeneID | 32 | |
| KEGG | hsa:32 | |
| UCSC | uc001tob.3 | |
| CTD | 32 | |
| GeneCards | GC12P109577 | |
| H-InvDB | HIX0036741 | |
| HGNC | HGNC:85 | |
| HPA | HPA006554 | |
| MIM | 601557 | |
| neXtProt | NX_O00763 | |
| PharmGKB | PA24422 | |
| eggNOG | COG0511 | |
| GeneTree | ENSGT00550000074703 | |
| HOVERGEN | HBG005371 | |
| InParanoid | O00763 | |
| KO | K11262 | |
| OMA | WYEENKK | |
| OrthoDB | EOG7HXCPW | |
| PhylomeDB | O00763 | |
| TreeFam | TF300061 | |
| BioCyc | MetaCyc:HS01211-MONOMER | |
| BRENDA | 6.4.1.2 | |
| Reactome | REACT_11082 REACT_11153 REACT_147904 REACT_169312 REACT_2122 | |
| SABIO-RK | O00763 | |
| UniPathway | UPA00655 | |
| ChiTaRS | ACACB | |
| EvolutionaryTrace | O00763 | |
| GeneWiki | ACACB | |
| GenomeRNAi | 32 | |
| NextBio | 123 | |
| PRO | PR:O00763 | |
| Proteomes | UP000005640 | |
| Bgee | O00763 | |
| CleanEx | HS_ACACB | |
| ExpressionAtlas | O00763 | |
| Genevestigator | O00763 | |
| GO | GO:0005829 GO:0012505 GO:0005741 GO:0005739 GO:0005634 GO:0003989 GO:0005524 GO:0009374 GO:0004075 GO:0046872 GO:0006084 GO:0006768 GO:0006853 GO:0044255 GO:0006112 GO:0006633 GO:2001295 GO:0031325 GO:0051289 GO:0042493 GO:0014070 GO:0044281 GO:0006766 GO:0006767 | |
| Gene3D | 3.30.1490.20 3.30.470.20 3.40.50.20 3.90.226.10 | |
| InterPro | IPR013537 IPR011761 IPR013815 IPR013816 IPR011764 IPR005482 IPR000089 IPR005481 IPR000022 IPR005479 IPR029045 IPR011763 IPR011762 IPR016185 IPR011054 IPR011053 | |
| Pfam | PF08326 PF02785 PF00364 PF01039 PF00289 PF02786 | |
| SMART | SM00878 | |
| SUPFAM | SSF51230 SSF51246 SSF52096 SSF52440 | |
| PROSITE | PS50975 PS50979 PS50968 PS50989 PS50980 PS00866 PS00867 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032868 |
response to insulin stimulus |
ECO:0000315 |
P |
Fig.2b |
complete | |||||
| GO:0071548 |
response to dexamethasone stimulus |
ECO:0000315 |
P |
Fig.3 |
complete | |||||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051289 |
protein homotetramerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006084 |
acetyl-CoA metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PSQ0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014070 |
response to organic cyclic compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PSQ0 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0009374 |
biotin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PSQ0 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PSQ0 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2001295 |
malonyl-CoA biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097009 |
energy homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060421 |
positive regulation of heart growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050995 |
negative regulation of lipid catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046322 |
negative regulation of fatty acid oxidation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043086 |
negative regulation of catalytic activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031999 |
negative regulation of fatty acid beta-oxidation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031667 |
response to nutrient levels |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010906 |
regulation of glucose metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010884 |
positive regulation of lipid storage |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9Q4Z2 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR005479 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004075 |
biotin carboxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045540 |
regulation of cholesterol biosynthetic process |
Reactome:R-HSA-1655829 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031325 |
positive regulation of cellular metabolic process |
Reactome:R-HSA-163765 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006853 |
carnitine shuttle |
Reactome:R-HSA-200425 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-1655830 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
Reactome:R-HSA-8876889 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0012505 |
endomembrane system |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001295 |
malonyl-CoA biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00655 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Zhao, LF et al. (2010) Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Endocr. J. 57 317-24 PubMed GONUTS page
- ↑ 2.0 2.1 Abu-Elheiga, L et al. (2000) The subcellular localization of acetyl-CoA carboxylase 2. Proc. Natl. Acad. Sci. U.S.A. 97 1444-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Colbert, CL et al. (2010) Crystal structure of Spot 14, a modulator of fatty acid synthesis. Proc. Natl. Acad. Sci. U.S.A. 107 18820-5 PubMed GONUTS page
- ↑ Kim, CW et al. (2010) Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proc. Natl. Acad. Sci. U.S.A. 107 9626-31 PubMed GONUTS page
a
c
e
m
n
- GO:0031999 ! negative regulation of fatty acid beta-oxidation
- GO:0010629 ! negative regulation of gene expression
- GO:0050995 ! negative regulation of lipid catabolic process
- GO:0046322 ! negative regulation of fatty acid oxidation
- GO:0043086 ! negative regulation of catalytic activity
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
p
r
- GO:0045540 ! regulation of cholesterol biosynthetic process
- GO:0010906 ! regulation of glucose metabolic process
- GO:0071548 ! response to dexamethasone
- GO:0031667 ! response to nutrient levels
- GO:0014070 ! response to organic cyclic compound
- GO:0042493 ! response to drug
- GO:0032868 ! response to insulin
