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HUMAN:AAPK1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | PRKAA1 (synonyms: AMPK1) | |
Protein Name(s) | 5'-AMP-activated protein kinase catalytic subunit alpha-1
AMPK subunit alpha-1 Acetyl-CoA carboxylase kinase ACACA kinase Hydroxymethylglutaryl-CoA reductase kinase HMGCR kinase Tau-protein kinase PRKAA1 | |
External Links | ||
UniProt | Q13131 | |
EMBL | AC008810 BC048980 AB022017 AK312947 BC037303 AF100763 U22456 Y12856 | |
CCDS | CCDS3932.2 CCDS3933.2 | |
PIR | G01743 | |
RefSeq | NP_006242.5 NP_996790.3 | |
UniGene | Hs.43322 | |
PDB | 4RED 4RER 4REW | |
PDBsum | 4RED 4RER 4REW | |
ProteinModelPortal | Q13131 | |
SMR | Q13131 | |
BioGrid | 111549 | |
DIP | DIP-39973N | |
IntAct | Q13131 | |
MINT | MINT-6771251 | |
STRING | 9606.ENSP00000346148 | |
BindingDB | Q13131 | |
ChEMBL | CHEMBL3038452 | |
DrugBank | DB00945 DB00131 DB00171 DB00914 | |
GuidetoPHARMACOLOGY | 1541 | |
PhosphoSite | Q13131 | |
DMDM | 254763436 | |
MaxQB | Q13131 | |
PaxDb | Q13131 | |
PRIDE | Q13131 | |
DNASU | 5562 | |
Ensembl | ENST00000354209 ENST00000397128 | |
GeneID | 5562 | |
KEGG | hsa:5562 | |
UCSC | uc003jmb.3 uc003jmc.3 | |
CTD | 5562 | |
GeneCards | GC05M040759 | |
H-InvDB | HIX0004832 | |
HGNC | HGNC:9376 | |
HPA | CAB005050 HPA035409 | |
MIM | 602739 | |
neXtProt | NX_Q13131 | |
PharmGKB | PA33744 | |
eggNOG | COG0515 | |
GeneTree | ENSGT00760000118892 | |
HOGENOM | HOG000233016 | |
HOVERGEN | HBG050432 | |
KO | K07198 | |
OMA | MKRATIR | |
OrthoDB | EOG7RRF6K | |
PhylomeDB | Q13131 | |
TreeFam | TF314032 | |
BRENDA | 2.7.11.1 | |
Reactome | REACT_21285 REACT_21393 | |
SignaLink | Q13131 | |
ChiTaRS | PRKAA1 | |
GeneWiki | Protein_kinase,_AMP-activated,_alpha_1 | |
GenomeRNAi | 5562 | |
NextBio | 21546 | |
PRO | PR:Q13131 | |
Proteomes | UP000005640 | |
Bgee | Q13131 | |
CleanEx | HS_PRKAA1 | |
ExpressionAtlas | Q13131 | |
Genevestigator | Q13131 | |
GO | GO:0031588 GO:0016324 GO:0005737 GO:0005829 GO:0005622 GO:0005654 GO:0005634 GO:0050405 GO:0047322 GO:0004679 GO:0005524 GO:0004691 GO:0003682 GO:0035174 GO:0046872 GO:0004672 GO:0050321 GO:0000187 GO:0006914 GO:0007050 GO:0071361 GO:0042149 GO:0070301 GO:0071456 GO:0031669 GO:0006695 GO:0009631 GO:0006633 GO:0055089 GO:0019395 GO:0042593 GO:0006006 GO:0008286 GO:0008610 GO:0043066 GO:2001274 GO:0046318 GO:0050995 GO:0032007 GO:0010508 GO:0008284 GO:0045542 GO:0010628 GO:0045821 GO:0051291 GO:0006468 GO:0042752 GO:2000505 GO:0006355 GO:0060627 GO:0014823 GO:0031000 GO:1901563 GO:0010332 GO:0001666 GO:0009411 GO:0048511 GO:0007165 GO:0006351 GO:0016055 | |
InterPro | IPR028375 IPR011009 IPR028797 IPR000719 IPR017441 IPR002290 IPR008271 | |
PANTHER | PTHR24343:SF81 | |
Pfam | PF00069 | |
SMART | SM00220 | |
SUPFAM | SSF103243 SSF56112 | |
PROSITE | PS00107 PS50011 PS00108 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0004331 |
fructose-2,6-bisphosphate 2-phosphatase activity |
ECO:0000315 |
F |
PFKFB4 is expressed in multiple normal tissues and over-expressed in human lung adenocarcinomas |
complete | |||||
involved_in |
GO:0061744 |
motor behavior |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070050 |
neuron cellular homeostasis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
occurs_in:(UBERON:0002435) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001873)|part_of:(UBERON:0001870) |
Seeded From UniProt |
complete | ||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002608) |
Seeded From UniProt |
complete | ||
part_of |
GO:0030425 |
dendrite |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002608) |
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002608) |
Seeded From UniProt |
complete | ||
enables |
GO:0004679 |
AMP-activated protein kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0071333 |
cellular response to glucose stimulus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0071277 |
cellular response to calcium ion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
enables |
GO:0004679 |
AMP-activated protein kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:2000758 |
positive regulation of peptidyl-lysine acetylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1904428 |
negative regulation of tubulin deacetylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1903829 |
positive regulation of cellular protein localization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0070507 |
regulation of microtubule cytoskeleton organization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
part_of:(GO:0034599) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
positively_regulates:(GO:0034063) |
Seeded From UniProt |
complete | ||
enables |
GO:0048156 |
tau protein binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050321 |
tau-protein kinase activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061762 |
CAMKK-AMPK signaling cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010508 |
positive regulation of autophagy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061762 |
CAMKK-AMPK signaling cascade |
ECO:0000305 |
curator inference used in manual assertion |
GO:0010508 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010508 |
positive regulation of autophagy |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097009 |
energy homeostasis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055089 |
fatty acid homeostasis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050995 |
negative regulation of lipid catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046318 |
negative regulation of glucosylceramide biosynthetic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045821 |
positive regulation of glycolytic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045542 |
positive regulation of cholesterol biosynthetic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042752 |
regulation of circadian rhythm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042593 |
glucose homeostasis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042149 |
cellular response to glucose starvation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0035174 |
histone serine kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032007 |
negative regulation of TOR signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031669 |
cellular response to nutrient levels |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0031588 |
nucleotide-activated protein kinase complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q8NFG4)|has_regulation_target:(UniProtKB:Q8TF40) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010508 |
positive regulation of autophagy |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010332 |
response to gamma radiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008610 |
lipid biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(UniProtKB:Q8TF40) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004691 |
cAMP-dependent protein kinase activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004679 |
AMP-activated protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003682 |
chromatin binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001666 |
response to hypoxia |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000187 |
activation of MAPK activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042149 |
cellular response to glucose starvation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1336173 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104754 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032007 |
negative regulation of TOR signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1336173 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031588 |
nucleotide-activated protein kinase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001217363 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0023169 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104754 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0023169 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0025625 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0016607 |
nuclear speck |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035404 |
histone-serine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0035174 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035404 |
histone-serine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0035174 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097009 |
energy homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071417 |
cellular response to organonitrogen compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071361 |
cellular response to ethanol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071333 |
cellular response to glucose stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071277 |
cellular response to calcium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070301 |
cellular response to hydrogen peroxide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060627 |
regulation of vesicle-mediated transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055089 |
fatty acid homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051291 |
protein heterooligomerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045821 |
positive regulation of glycolytic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0031588 |
nucleotide-activated protein kinase complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031000 |
response to caffeine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030425 |
dendrite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0014823 |
response to activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009631 |
cold acclimation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004679 |
AMP-activated protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54645 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000758 |
positive regulation of peptidyl-lysine acetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904428 |
negative regulation of tubulin deacetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903955 |
positive regulation of protein targeting to mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903829 |
positive regulation of cellular protein localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903109 |
positive regulation of mitochondrial transcription |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901563 |
response to camptothecin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071380 |
cellular response to prostaglandin E stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071333 |
cellular response to glucose stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071277 |
cellular response to calcium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070507 |
regulation of microtubule cytoskeleton organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0062028 |
regulation of stress granule assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050995 |
negative regulation of lipid catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048643 |
positive regulation of skeletal muscle tissue development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042752 |
regulation of circadian rhythm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042593 |
glucose homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042542 |
response to hydrogen peroxide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042149 |
cellular response to glucose starvation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0035174 |
histone serine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033135 |
regulation of peptidyl-serine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032007 |
negative regulation of TOR signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031669 |
cellular response to nutrient levels |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030425 |
dendrite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019395 |
fatty acid oxidation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010508 |
positive regulation of autophagy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010332 |
response to gamma radiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009411 |
response to UV |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008610 |
lipid biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006006 |
glucose metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004679 |
AMP-activated protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003682 |
chromatin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5EG47 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004679 |
AMP-activated protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050405 |
[acetyl-CoA carboxylase] kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0047322 |
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050321 |
tau-protein kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004679 |
AMP-activated protein kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061762 |
CAMKK-AMPK signaling cascade |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0031588 |
nucleotide-activated protein kinase complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097009 |
energy homeostasis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901796 |
regulation of signal transduction by p53 class mediator |
Reactome:R-HSA-5633007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016241 |
regulation of macroautophagy |
Reactome:R-HSA-5673768 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016236 |
macroautophagy |
Reactome:R-HSA-1632852 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007050 |
cell cycle arrest |
Reactome:R-HSA-380972 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5679239 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6805470 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006695 |
cholesterol biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008203 |
cholesterol metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006914 |
autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016126 |
sterol biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006694 |
steroid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008202 |
steroid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Chesney, J et al. (2014) Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth. Oncotarget 5 6670-86 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Ju, TC et al. (2011) Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. J. Cell Biol. 194 209-27 PubMed GONUTS page
- ↑ 3.0 3.1 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
- ↑ 4.0 4.1 Sinha, RA et al. (2015) Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. Autophagy 11 1341-57 PubMed GONUTS page
- ↑ 5.0 5.1 Gómez-Suaga, P et al. (2012) Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum. Mol. Genet. 21 511-25 PubMed GONUTS page
- ↑ Blázquez, C et al. (2001) The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes. FEBS Lett. 489 149-53 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Stapleton, D et al. (1996) Mammalian AMP-activated protein kinase subfamily. J. Biol. Chem. 271 611-4 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Baba, M et al. (2006) Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. U.S.A. 103 15552-7 PubMed GONUTS page
- ↑ Gwinn, DM et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 214-26 PubMed GONUTS page
- ↑ Xi, X et al. (2001) Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. J. Biol. Chem. 276 41029-34 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
a
c
- GO:0061762 ! CAMKK-AMPK signaling cascade
- GO:0004691 ! cAMP-dependent protein kinase activity
- Catarrhini
- GO:0034613 ! cellular protein localization
- GO:0031669 ! cellular response to nutrient levels
- GO:0071380 ! cellular response to prostaglandin E stimulus
- GO:0042149 ! cellular response to glucose starvation
- GO:0071456 ! cellular response to hypoxia
- GO:0070301 ! cellular response to hydrogen peroxide
- GO:0034599 ! cellular response to oxidative stress
- GO:0071333 ! cellular response to glucose stimulus
- GO:0071277 ! cellular response to calcium ion
- GO:0071361 ! cellular response to ethanol
- GO:0007050 ! cell cycle arrest
- GO:0008203 ! cholesterol metabolic process
- GO:0006695 ! cholesterol biosynthetic process
- Chordata
- GO:0003682 ! chromatin binding
- GO:0006325 ! chromatin organization
- GO:0009631 ! cold acclimation
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
f
m
n
- GO:0032007 ! negative regulation of TOR signaling
- GO:0046318 ! negative regulation of glucosylceramide biosynthetic process
- GO:0010629 ! negative regulation of gene expression
- GO:0043066 ! negative regulation of apoptotic process
- GO:0046627 ! negative regulation of insulin receptor signaling pathway
- GO:1904428 ! negative regulation of tubulin deacetylation
- GO:0050995 ! negative regulation of lipid catabolic process
- GO:0043025 ! neuronal cell body
- GO:0070050 ! neuron cellular homeostasis
- GO:0016607 ! nuclear speck
- GO:0005654 ! nucleoplasm
- GO:0031588 ! nucleotide-activated protein kinase complex
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
o
- GO:0050405 ! obsolete (acetyl-CoA carboxylase) kinase activity
- GO:0000187 ! obsolete activation of MAPK activity
- GO:0071417 ! obsolete cellular response to organonitrogen compound
- GO:0035404 ! obsolete histone-serine phosphorylation
- GO:0035174 ! obsolete histone serine kinase activity
- GO:0008022 ! obsolete protein C-terminus binding
p
- GO:0016310 ! phosphorylation
- GO:0045821 ! positive regulation of glycolytic process
- GO:1903955 ! positive regulation of protein targeting to mitochondrion
- GO:0010508 ! positive regulation of autophagy
- GO:0048643 ! positive regulation of skeletal muscle tissue development
- GO:0010628 ! positive regulation of gene expression
- GO:1903109 ! positive regulation of mitochondrial transcription
- GO:1903829 ! positive regulation of protein localization
- GO:0008284 ! positive regulation of cell population proliferation
- GO:2000758 ! positive regulation of peptidyl-lysine acetylation
- GO:0045542 ! positive regulation of cholesterol biosynthetic process
- Primates
- GO:0032991 ! protein-containing complex
- GO:0051291 ! protein heterooligomerization
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r
- GO:0033135 ! regulation of peptidyl-serine phosphorylation
- GO:0060627 ! regulation of vesicle-mediated transport
- GO:0070507 ! regulation of microtubule cytoskeleton organization
- GO:0062028 ! regulation of stress granule assembly
- GO:0016241 ! regulation of macroautophagy
- GO:1901796 ! regulation of signal transduction by p53 class mediator
- GO:0042752 ! regulation of circadian rhythm
- GO:0009411 ! response to UV
- GO:0001666 ! response to hypoxia
- GO:1901563 ! response to camptothecin
- GO:0010332 ! response to gamma radiation
- GO:0014823 ! response to activity
- GO:0031000 ! response to caffeine
- GO:0042542 ! response to hydrogen peroxide
- GO:0048511 ! rhythmic process
s
t