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HUMAN:AAPK1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PRKAA1 (synonyms: AMPK1)
Protein Name(s) 5'-AMP-activated protein kinase catalytic subunit alpha-1

AMPK subunit alpha-1 Acetyl-CoA carboxylase kinase ACACA kinase Hydroxymethylglutaryl-CoA reductase kinase HMGCR kinase Tau-protein kinase PRKAA1

External Links
UniProt Q13131
EMBL AC008810
BC048980
AB022017
AK312947
BC037303
AF100763
U22456
Y12856
CCDS CCDS3932.2
CCDS3933.2
PIR G01743
RefSeq NP_006242.5
NP_996790.3
UniGene Hs.43322
PDB 4RED
4RER
4REW
PDBsum 4RED
4RER
4REW
ProteinModelPortal Q13131
SMR Q13131
BioGrid 111549
DIP DIP-39973N
IntAct Q13131
MINT MINT-6771251
STRING 9606.ENSP00000346148
BindingDB Q13131
ChEMBL CHEMBL3038452
DrugBank DB00945
DB00131
DB00171
DB00914
GuidetoPHARMACOLOGY 1541
PhosphoSite Q13131
DMDM 254763436
MaxQB Q13131
PaxDb Q13131
PRIDE Q13131
DNASU 5562
Ensembl ENST00000354209
ENST00000397128
GeneID 5562
KEGG hsa:5562
UCSC uc003jmb.3
uc003jmc.3
CTD 5562
GeneCards GC05M040759
H-InvDB HIX0004832
HGNC HGNC:9376
HPA CAB005050
HPA035409
MIM 602739
neXtProt NX_Q13131
PharmGKB PA33744
eggNOG COG0515
GeneTree ENSGT00760000118892
HOGENOM HOG000233016
HOVERGEN HBG050432
KO K07198
OMA MKRATIR
OrthoDB EOG7RRF6K
PhylomeDB Q13131
TreeFam TF314032
BRENDA 2.7.11.1
Reactome REACT_21285
REACT_21393
SignaLink Q13131
ChiTaRS PRKAA1
GeneWiki Protein_kinase,_AMP-activated,_alpha_1
GenomeRNAi 5562
NextBio 21546
PRO PR:Q13131
Proteomes UP000005640
Bgee Q13131
CleanEx HS_PRKAA1
ExpressionAtlas Q13131
Genevestigator Q13131
GO GO:0031588
GO:0016324
GO:0005737
GO:0005829
GO:0005622
GO:0005654
GO:0005634
GO:0050405
GO:0047322
GO:0004679
GO:0005524
GO:0004691
GO:0003682
GO:0035174
GO:0046872
GO:0004672
GO:0050321
GO:0000187
GO:0006914
GO:0007050
GO:0071361
GO:0042149
GO:0070301
GO:0071456
GO:0031669
GO:0006695
GO:0009631
GO:0006633
GO:0055089
GO:0019395
GO:0042593
GO:0006006
GO:0008286
GO:0008610
GO:0043066
GO:2001274
GO:0046318
GO:0050995
GO:0032007
GO:0010508
GO:0008284
GO:0045542
GO:0010628
GO:0045821
GO:0051291
GO:0006468
GO:0042752
GO:2000505
GO:0006355
GO:0060627
GO:0014823
GO:0031000
GO:1901563
GO:0010332
GO:0001666
GO:0009411
GO:0048511
GO:0007165
GO:0006351
GO:0016055
InterPro IPR028375
IPR011009
IPR028797
IPR000719
IPR017441
IPR002290
IPR008271
PANTHER PTHR24343:SF81
Pfam PF00069
SMART SM00220
SUPFAM SSF103243
SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004331

fructose-2,6-bisphosphate 2-phosphatase activity

PMID:25115398[1]

ECO:0000315

F

PFKFB4 is expressed in multiple normal tissues and over-expressed in human lung adenocarcinomas

complete
CACAO 10772

involved_in

GO:0061744

motor behavior

PMID:21768291[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P42858

P

Seeded From UniProt

complete

involved_in

GO:0070050

neuron cellular homeostasis

PMID:21768291[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P42858

P

occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21768291[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001873)|part_of:(UBERON:0001870)

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54645

C

part_of:(CL:0002608)

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54645

C

part_of:(CL:0002608)

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54645

C

part_of:(CL:0002608)

Seeded From UniProt

complete

enables

GO:0004679

AMP-activated protein kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54645

F

Seeded From UniProt

complete

involved_in

GO:0071333

cellular response to glucose stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54645

P

Seeded From UniProt

complete

involved_in

GO:0071277

cellular response to calcium ion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54645

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

  • part_of:(GO:0034599)
  • positively_regulates:(GO:0034063)
  • regulates_expression_of:(ENSEMBL:ENSG00000114867)|part_of(GO:0034599)
  • positively_regulates:(GO:0034063)
  • regulates_expression_of:(ENSEMBL:ENSG00000151247)|part_of(GO:0034599)
  • regulates_expression_of:(ENSEMBL:ENSG00000094631)

Seeded From UniProt

complete

enables

GO:0004679

AMP-activated protein kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

F

Seeded From UniProt

complete

involved_in

GO:2000758

positive regulation of peptidyl-lysine acetylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:1904428

negative regulation of tubulin deacetylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:1903829

positive regulation of cellular protein localization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:0070507

regulation of microtubule cytoskeleton organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

part_of:(GO:0034599)

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

positively_regulates:(GO:0034063)

Seeded From UniProt

complete

enables

GO:0048156

tau protein binding

PMID:28386764[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050321

tau-protein kinase activity

PMID:28386764[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0061762

CAMKK-AMPK signaling cascade

PMID:26103054[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010508

positive regulation of autophagy

PMID:26103054[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061762

CAMKK-AMPK signaling cascade

PMID:22012985[5]

ECO:0000305

curator inference used in manual assertion

GO:0010508

P

Seeded From UniProt

complete

involved_in

GO:0010508

positive regulation of autophagy

PMID:22012985[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097009

energy homeostasis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54645

P

Seeded From UniProt

complete

involved_in

GO:0055089

fatty acid homeostasis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54645

P

Seeded From UniProt

complete

involved_in

GO:0050995

negative regulation of lipid catabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:0046318

negative regulation of glucosylceramide biosynthetic process

PMID:11165240[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045821

positive regulation of glycolytic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54645

P

Seeded From UniProt

complete

involved_in

GO:0045542

positive regulation of cholesterol biosynthetic process

PMID:8557660[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:0042593

glucose homeostasis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:0042149

cellular response to glucose starvation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

enables

GO:0035174

histone serine kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

F

Seeded From UniProt

complete

involved_in

GO:0032007

negative regulation of TOR signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:0031669

cellular response to nutrient levels

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54645

C

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:17028174[8]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q8NFG4)|has_regulation_target:(UniProtKB:Q8TF40)

Seeded From UniProt

complete

involved_in

GO:0010508

positive regulation of autophagy

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:0010332

response to gamma radiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:0008610

lipid biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:17028174[8]

ECO:0000314

direct assay evidence used in manual assertion

P

has_input:(UniProtKB:Q8TF40)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

C

Seeded From UniProt

complete

enables

GO:0004691

cAMP-dependent protein kinase activity

PMID:8557660[7]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004679

AMP-activated protein kinase activity

PMID:18439900[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:17028174[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5EG47

F

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:8557660[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000187

activation of MAPK activity

PMID:11546797[10]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042149

cellular response to glucose starvation

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1336173
MGI:MGI:2145955
PANTHER:PTN001217363

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104754
MGI:MGI:2445031
PANTHER:PTN000678822
UniProtKB:P57059
UniProtKB:Q9H0K1
UniProtKB:Q9IA88

P

Seeded From UniProt

complete

involved_in

GO:0032007

negative regulation of TOR signaling

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1336173
MGI:MGI:2145955
PANTHER:PTN001217363

P

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001217363
RGD:3387
RGD:620893

C

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023169
FB:FBgn0261278
MGI:MGI:104754
MGI:MGI:1202065
MGI:MGI:1336173
MGI:MGI:1347352
MGI:MGI:1351488
MGI:MGI:1923020
MGI:MGI:2445031
MGI:MGI:3037705
PANTHER:PTN000678822
RGD:1359167
RGD:3387
RGD:620545
RGD:620893
RGD:69407
RGD:69653
SGD:S000000931
SGD:S000001531
SGD:S000001584
SGD:S000002529
SGD:S000002885
SGD:S000004086
SGD:S000005127
TAIR:locus:2094672
UniProtKB:O60285
UniProtKB:P57059
UniProtKB:Q13131
UniProtKB:Q6SA08
UniProtKB:Q8IWQ3
UniProtKB:Q8IY84
UniProtKB:Q8TDC3
UniProtKB:Q9BXA6
UniProtKB:Q9BXA7
UniProtKB:Q9H093
UniProtKB:Q9H0K1
UniProtKB:Q9IA88
UniProtKB:Q9NRH2

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104754
MGI:MGI:106924
MGI:MGI:1347559
MGI:MGI:2145955
MGI:MGI:2445031
PANTHER:PTN000678822
PomBase:SPAC23H4.02
PomBase:SPBC32C12.03c
PomBase:SPCC297.03
PomBase:SPCC74.03c
RGD:3387
RGD:620893
SGD:S000000601
SGD:S000000931
SGD:S000001124
SGD:S000001651
SGD:S000002885
SGD:S000003820
SGD:S000005127
SGD:S000006062
TAIR:locus:2009812
TAIR:locus:2032075
TAIR:locus:2140104
TAIR:locus:2174999
UniProtKB:O14757
UniProtKB:O60285
UniProtKB:P57059
UniProtKB:Q39192
UniProtKB:Q57YE4
UniProtKB:Q7XQP4
UniProtKB:Q8I3C7
UniProtKB:Q8IWQ3
UniProtKB:Q8TDC3
UniProtKB:Q940H6
UniProtKB:Q9IA88
WB:WBGene00002210
WB:WBGene00003919
WB:WBGene00020142
WB:WBGene00021012

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023169
FB:FBgn0261278
MGI:MGI:104754
MGI:MGI:1202065
MGI:MGI:1336173
MGI:MGI:2145955
MGI:MGI:2445031
PANTHER:PTN000678822
PomBase:SPAC23H4.02
PomBase:SPBC19C2.05
PomBase:SPCC74.03c
RGD:69407
RGD:69653
SGD:S000001124
SGD:S000002885
SGD:S000003820
SGD:S000005947
TAIR:locus:2009812
TAIR:locus:2032075
TAIR:locus:2140104
TAIR:locus:2159597
TAIR:locus:2160559
TAIR:locus:2174999
UniProtKB:O14757
UniProtKB:O60285
UniProtKB:P43291
UniProtKB:P57059
UniProtKB:Q39192
UniProtKB:Q5N942
UniProtKB:Q7XQP4
UniProtKB:Q8TDC3
UniProtKB:Q940H6
WB:WBGene00002210

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025625
MGI:MGI:104754
MGI:MGI:106924
MGI:MGI:1336173
MGI:MGI:1347559
MGI:MGI:1923020
MGI:MGI:2445031
MGI:MGI:2685946
PANTHER:PTN000678822
PomBase:SPAC57A10.02
PomBase:SPAC644.06c
PomBase:SPBC19C2.05
PomBase:SPBC4F6.06
PomBase:SPCC1020.10
PomBase:SPCC297.03
PomBase:SPCC74.03c
RGD:1359167
RGD:1563268
RGD:1566256
RGD:3387
RGD:620893
RGD:69407
RGD:69653
SGD:S000000931
SGD:S000001531
SGD:S000001584
SGD:S000002529
SGD:S000002885
SGD:S000004086
SGD:S000005127
SGD:S000005759
TAIR:locus:2009812
TAIR:locus:2094672
TAIR:locus:2102132
UniProtKB:O14757
UniProtKB:O60285
UniProtKB:P57059
UniProtKB:Q14680
UniProtKB:Q6SA08
UniProtKB:Q8IWQ3
UniProtKB:Q8IY84
UniProtKB:Q8TDC3
UniProtKB:Q96PF2
UniProtKB:Q9BXA6
UniProtKB:Q9BXA7
UniProtKB:Q9H093
UniProtKB:Q9H0K1
UniProtKB:Q9IA88
UniProtKB:Q9NRH2
UniProtKB:Q9STV4
WB:WBGene00003919

F

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0035404

histone-serine phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0035174

P

Seeded From UniProt

complete

involved_in

GO:0035404

histone-serine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0035174

P

Seeded From UniProt

complete

involved_in

GO:0097009

energy homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0071417

cellular response to organonitrogen compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0071361

cellular response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0071333

cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0071277

cellular response to calcium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0060627

regulation of vesicle-mediated transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0055089

fatty acid homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0051291

protein heterooligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0046627

negative regulation of insulin receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0045821

positive regulation of glycolytic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

C

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

C

Seeded From UniProt

complete

involved_in

GO:0031000

response to caffeine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

C

Seeded From UniProt

complete

involved_in

GO:0014823

response to activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0009631

cold acclimation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

F

Seeded From UniProt

complete

enables

GO:0004679

AMP-activated protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54645
ensembl:ENSRNOP00000017626

F

Seeded From UniProt

complete

involved_in

GO:2000758

positive regulation of peptidyl-lysine acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:1904428

negative regulation of tubulin deacetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:1903955

positive regulation of protein targeting to mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:1903829

positive regulation of cellular protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:1903109

positive regulation of mitochondrial transcription

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:1901563

response to camptothecin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0071380

cellular response to prostaglandin E stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0071333

cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0071277

cellular response to calcium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0070507

regulation of microtubule cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0062028

regulation of stress granule assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0050995

negative regulation of lipid catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0048643

positive regulation of skeletal muscle tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

C

Seeded From UniProt

complete

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0042593

glucose homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0042542

response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0042149

cellular response to glucose starvation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

enables

GO:0035174

histone serine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

F

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0033135

regulation of peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0032007

negative regulation of TOR signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0031669

cellular response to nutrient levels

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

C

Seeded From UniProt

complete

involved_in

GO:0019395

fatty acid oxidation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0010508

positive regulation of autophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0010332

response to gamma radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0009411

response to UV

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0008610

lipid biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

involved_in

GO:0006006

glucose metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

C

Seeded From UniProt

complete

enables

GO:0004679

AMP-activated protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5EG47
ensembl:ENSMUSP00000063166

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004679

AMP-activated protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039137

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0050405

[acetyl-CoA carboxylase] kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.27

F

Seeded From UniProt

complete

enables

GO:0047322

[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.31

F

Seeded From UniProt

complete

enables

GO:0050321

tau-protein kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.26

F

Seeded From UniProt

complete

enables

GO:0004679

AMP-activated protein kinase activity

PMID:21768291[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0061762

CAMKK-AMPK signaling cascade

PMID:21768291[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

PMID:21768291[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0097009

energy homeostasis

PMID:21768291[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:8557660[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:8557660[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:8557660[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016241

regulation of macroautophagy

Reactome:R-HSA-5673768

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

Reactome:R-HSA-1632852

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

Reactome:R-HSA-380972

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5679239
Reactome:R-HSA-5679205
Reactome:R-HSA-5675868
Reactome:R-HSA-5673768
Reactome:R-HSA-5672011
Reactome:R-HSA-5672008
Reactome:R-HSA-5665868
Reactome:R-HSA-5631941
Reactome:R-HSA-447074
Reactome:R-HSA-380949
Reactome:R-HSA-380930
Reactome:R-HSA-380927
Reactome:R-HSA-200421
Reactome:R-HSA-1632857

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6805470

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006695

cholesterol biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0152

P

Seeded From UniProt

complete

involved_in

GO:0008203

cholesterol metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0153

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

involved_in

GO:0016126

sterol biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0756

P

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006694

steroid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0752

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0008202

steroid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0753

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Chesney, J et al. (2014) Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth. Oncotarget 5 6670-86 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Ju, TC et al. (2011) Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. J. Cell Biol. 194 209-27 PubMed GONUTS page
  3. 3.0 3.1 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
  4. 4.0 4.1 Sinha, RA et al. (2015) Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. Autophagy 11 1341-57 PubMed GONUTS page
  5. 5.0 5.1 Gómez-Suaga, P et al. (2012) Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum. Mol. Genet. 21 511-25 PubMed GONUTS page
  6. Blázquez, C et al. (2001) The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes. FEBS Lett. 489 149-53 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 Stapleton, D et al. (1996) Mammalian AMP-activated protein kinase subfamily. J. Biol. Chem. 271 611-4 PubMed GONUTS page
  8. 8.0 8.1 8.2 Baba, M et al. (2006) Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. U.S.A. 103 15552-7 PubMed GONUTS page
  9. Gwinn, DM et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 214-26 PubMed GONUTS page
  10. Xi, X et al. (2001) Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. J. Biol. Chem. 276 41029-34 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page