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HUMAN:5HT3B
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | HTR3B | |
| Protein Name(s) | 5-hydroxytryptamine receptor 3B
5-HT3-B 5-HT3B Serotonin receptor 3B | |
| External Links | ||
| UniProt | O95264 | |
| EMBL | AF169255 AF080582 AM293589 EF444985 AK314268 | |
| CCDS | CCDS8364.1 | |
| RefSeq | NP_006019.1 | |
| UniGene | Hs.241377 | |
| ProteinModelPortal | O95264 | |
| SMR | O95264 | |
| STRING | 9606.ENSP00000260191 | |
| BindingDB | O95264 | |
| ChEMBL | CHEMBL2096904 | |
| DrugBank | DB01049 | |
| GuidetoPHARMACOLOGY | 374 | |
| PhosphoSite | O95264 | |
| PaxDb | O95264 | |
| PRIDE | O95264 | |
| DNASU | 9177 | |
| Ensembl | ENST00000260191 ENST00000537778 | |
| GeneID | 9177 | |
| KEGG | hsa:9177 | |
| UCSC | uc001pok.3 uc001pol.3 | |
| CTD | 9177 | |
| GeneCards | GC11P113775 | |
| HGNC | HGNC:5298 | |
| HPA | HPA039559 | |
| MIM | 604654 | |
| neXtProt | NX_O95264 | |
| PharmGKB | PA29556 | |
| eggNOG | NOG260507 | |
| GeneTree | ENSGT00770000120477 | |
| HOGENOM | HOG000241519 | |
| HOVERGEN | HBG106638 | |
| InParanoid | O95264 | |
| KO | K04819 | |
| OMA | SWNSSMF | |
| OrthoDB | EOG7FXZZK | |
| PhylomeDB | O95264 | |
| TreeFam | TF315605 | |
| Reactome | REACT_25387 | |
| GeneWiki | HTR3B | |
| GenomeRNAi | 9177 | |
| NextBio | 34409 | |
| PRO | PR:O95264 | |
| Proteomes | UP000005640 | |
| Bgee | O95264 | |
| CleanEx | HS_HTR3B | |
| ExpressionAtlas | O95264 | |
| Genevestigator | O95264 | |
| GO | GO:0005887 GO:0005886 GO:0045211 GO:0005216 GO:0004993 GO:0005232 GO:0098655 GO:0034220 GO:0007268 GO:0055085 GO:0006810 | |
| Gene3D | 1.20.120.370 2.70.170.10 | |
| InterPro | IPR008132 IPR008134 IPR027361 IPR006202 IPR006201 IPR006029 | |
| PANTHER | PTHR18945 | |
| Pfam | PF02931 PF02932 | |
| PRINTS | PR01710 PR01708 PR00252 | |
| SUPFAM | SSF63712 SSF90112 | |
| TIGRFAMs | TIGR00860 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0009986 |
cell surface |
ECO:0000314 |
C |
Figure 2 shows that subunit 5HT3B is only expressed on the cell membrane when it is co-expressed with 5HT3A |
complete | |||||
|
part_of |
GO:1904602 |
serotonin-activated cation-selective channel complex |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0022850 |
serotonin-gated cation-selective channel activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050877 |
nervous system process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87888 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95747 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95747 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042391 |
regulation of membrane potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87885 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95613 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003011 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000434994 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1861899 |
C |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0005230 |
extracellular ligand-gated ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000434994 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007210 |
serotonin receptor signaling pathway |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0022850 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007210 |
serotonin receptor signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0022850 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0022850 |
serotonin-gated cation-selective channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JHJ5 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JHJ5 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005230 |
extracellular ligand-gated ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR006029 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015276 |
ligand-gated ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR006029 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
Reactome:R-HSA-112315 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-975311 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Reeves, DC & Lummis, SC (2006) Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies. BMC Neurosci 7 27 PubMed GONUTS page
- ↑ 2.0 2.1 Davies, PA et al. (1999) The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature 397 359-63 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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