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Category:GO:1904602 ! serotonin-activated cation-selective channel complex
name: serotonin-activated cation-selective channel complex
namespace: cellular_component
def: "A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092]
comment: An example of this is HTR3A in human (P46098) in PMID:16116092 (inferred from direct assay).
synonym: "5-HT-3 receptor complex" EXACT []
synonym: "5-HT3 receptor complex" EXACT []
synonym: "5-hydroxytryptamine receptor 3 complex" EXACT []
synonym: "5HT3 receptor complex" EXACT []
synonym: "serotonin receptor complex" BROAD []
is_a: GO:0034703 ! cation channel complex
is_a: GO:0098665 ! serotonin receptor complex
is_a: GO:0098878 ! neurotransmitter receptor complex
AmiGO
<GOterm>GO:1904602</GOterm>
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