HUMAN:5HT3A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HTR3A (synonyms: 5HT3R, HTR3)
Protein Name(s)	5-hydroxytryptamine receptor 3A 5-HT3-A 5-HT3A 5-hydroxytryptamine receptor 3 5-HT-3 5-HT3R Serotonin receptor 3A Serotonin-gated ion channel receptor
External Links
UniProt	P46098
EMBL	D49394 S82612 AJ003078 AJ003079 AJ005205 AF498984 BT007204 CD014118 AK299973 AP000908 CH471065 CH471065 BC002354 BC004453
CCDS	CCDS53710.1 CCDS8365.2 CCDS8366.2
RefSeq	NP_000860.2 NP_001155244.1 NP_998786.2
UniGene	Hs.413899
ProteinModelPortal	P46098
SMR	P46098
STRING	9606.ENSP00000347754
BindingDB	P46098
ChEMBL	CHEMBL1899
DrugBank	DB00969 DB00543 DB01238 DB01161 DB00604 DB00363 DB00757 DB01049 DB00889 DB00408 DB01043 DB00333 DB01233 DB00370 DB00334 DB00904 DB00377 DB00721 DB01224 DB00728 DB06204 DB00726 DB01199 DB00246
GuidetoPHARMACOLOGY	373
TCDB	1.A.9.2.1
PhosphoSite	P46098
DMDM	1168222
PaxDb	P46098
PRIDE	P46098
DNASU	3359
Ensembl	ENST00000299961 ENST00000355556 ENST00000375498 ENST00000504030 ENST00000506841
GeneID	3359
KEGG	hsa:3359
UCSC	uc010rxa.2 uc010rxb.2 uc010rxc.2
CTD	3359
GeneCards	GC11P113879
HGNC	HGNC:5297
MIM	182139
neXtProt	NX_P46098
PharmGKB	PA29555
eggNOG	NOG302526
GeneTree	ENSGT00770000120477
HOGENOM	HOG000241519
HOVERGEN	HBG106638
InParanoid	P46098
KO	K04819
OMA	FIVRLVH
OrthoDB	EOG7KDF9H
PhylomeDB	P46098
TreeFam	TF315605
Reactome	REACT_25387
GeneWiki	HTR3A
GenomeRNAi	3359
NextBio	13282
PRO	PR:P46098
Proteomes	UP000005640
Bgee	P46098
CleanEx	HS_HTR3A
ExpressionAtlas	P46098
Genevestigator	P46098
GO	GO:0030424 GO:0030054 GO:0005737 GO:0005887 GO:0043025 GO:0005886 GO:0045211 GO:0004872 GO:0051378 GO:0004993 GO:0005232 GO:0005249 GO:0071363 GO:0007586 GO:0034220 GO:0042220 GO:0045471 GO:0007210 GO:0007268 GO:0055085 GO:0006810
Gene3D	1.20.120.370 2.70.170.10
InterPro	IPR008132 IPR008133 IPR027361 IPR006202 IPR006201 IPR006029 IPR018000
PANTHER	PTHR18945
Pfam	PF02931 PF02932
PRINTS	PR01709 PR01708 PR00252
SUPFAM	SSF63712 SSF90112
TIGRFAMs	TIGR00860
PROSITE	PS00236

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0022850	serotonin-gated cation-selective channel activity	PMID:9950429^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:1904602	serotonin-activated cation-selective channel complex	PMID:9950429^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	PMID:19799413^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P43681	P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 UniProtKB:G5EDF1 UniProtKB:P11230 WB:WBGene00006765 WB:WBGene00006774	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 RGD:2351 RGD:621544 WB:WBGene00000042 WB:WBGene00002974 WB:WBGene00006765 WB:WBGene00006774	C	Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87887 MGI:MGI:87888 MGI:MGI:87890 MGI:MGI:87891 MGI:MGI:87892 MGI:MGI:87893 MGI:MGI:87894 MGI:MGI:87895 MGI:MGI:95747 MGI:MGI:95751 MGI:MGI:99779 PANTHER:PTN000434994 RGD:2348 UniProtKB:P02708 UniProtKB:P23415	P	Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95613 PANTHER:PTN000434994 UniProtKB:P23416 UniProtKB:P36544 UniProtKB:Q401N2 WB:WBGene00000055 WB:WBGene00002974 WB:WBGene00006797	P	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003011 FB:FBgn0086778 MGI:MGI:103156 MGI:MGI:95613 MGI:MGI:95623 MGI:MGI:95747 PANTHER:PTN000434994 RGD:2648 RGD:61859 RGD:61901 UniProtKB:P48167 WB:WBGene00000050 WB:WBGene00000054	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P30926 UniProtKB:P32297 UniProtKB:P36544 UniProtKB:P43681 UniProtKB:Q15822	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861899 MGI:MGI:95623 MGI:MGI:95750 PANTHER:PTN000434994 RGD:2649 RGD:2650 RGD:61855 RGD:61861 RGD:621229 UniProtKB:O75311 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P28472 UniProtKB:P48167 UniProtKB:Q9UGM1 WB:WBGene00000955 WB:WBGene00001133 WB:WBGene00001591 WB:WBGene00001592	C	Seeded From UniProt	complete
contributes_to	GO:0005230	extracellular ligand-gated ion channel activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 WB:WBGene00000043 WB:WBGene00001512 WB:WBGene00003386 WB:WBGene00006774 WB:WBGene00012857 WB:WBGene00017375	F	Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:7565620^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0022850	serotonin-gated cation-selective channel activity	PMID:7565620^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022850	P	Seeded From UniProt	complete
involved_in	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022850	P	Seeded From UniProt	complete
involved_in	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022850	P	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	C	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	C	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	C	Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	C	Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	P	Seeded From UniProt	complete
involved_in	GO:0032414	positive regulation of ion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	C	Seeded From UniProt	complete
enables	GO:0022850	serotonin-gated cation-selective channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35563 ensembl:ENSRNOP00000008965	C	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	F	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	F	Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006202 InterPro:IPR036734	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006029 InterPro:IPR006202 InterPro:IPR008132 InterPro:IPR008133 InterPro:IPR036719 InterPro:IPR036734	P	Seeded From UniProt	complete
enables	GO:0015276	ligand-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008132 InterPro:IPR008133	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006029 InterPro:IPR006201 InterPro:IPR006202 InterPro:IPR008132 InterPro:IPR008133 InterPro:IPR036719 InterPro:IPR036734	C	Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	P	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008132 InterPro:IPR008133	C	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	Reactome:R-HSA-112315	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-975311	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Davies, PA et al. (1999) The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature 397 359-63 PubMed GONUTS page
↑ Chen, TC et al. (2009) From midbody protein-protein interaction network construction to novel regulators in cytokinesis. J. Proteome Res. 8 4943-53 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Miyake, A et al. (1995) Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. Mol. Pharmacol. 48 407-16 PubMed GONUTS page

[PMID:9950429-1] 1.0 ^1.1 Davies, PA et al. (1999) The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature 397 359-63 PubMed GONUTS page

[PMID:19799413-2] Chen, TC et al. (2009) From midbody protein-protein interaction network construction to novel regulators in cytokinesis. J. Proteome Res. 8 4943-53 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7565620-4] 4.0 ^4.1 Miyake, A et al. (1995) Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. Mol. Pharmacol. 48 407-16 PubMed GONUTS page

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HUMAN:5HT3A

Contents

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References

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