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HHV11:ICP0
Contents
| Species (Taxon ID) | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1). (10299) | |
| Gene Name(s) | ICP0 (synonyms: IE110) | |
| Protein Name(s) | E3 ubiquitin-protein ligase ICP0
Alpha-0 protein Immediate-early protein IE110 Trans-acting transcriptional protein ICP0 VMW110 | |
| External Links | ||
| UniProt | P08393 | |
| EMBL | X14112 X14112 X04614 | |
| PIR | A29152 | |
| RefSeq | NP_044601.1 NP_044660.1 | |
| ProteinModelPortal | P08393 | |
| DIP | DIP-42446N | |
| IntAct | P08393 | |
| MINT | MINT-1345075 | |
| GeneID | 2703389 2703390 | |
| Proteomes | UP000009294 | |
| GO | GO:0030430 GO:0042025 GO:0019033 GO:0003677 GO:0016874 GO:0004842 GO:0008270 GO:0075342 GO:0039648 GO:0045732 GO:0000209 GO:0019046 GO:0034340 GO:0039593 GO:0039548 GO:0006351 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR018957 IPR001841 IPR013083 IPR017907 | |
| Pfam | PF00097 | |
| SMART | SM00184 | |
| PROSITE | PS00518 PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000314 |
P |
Figure 1 shows ICP0 inhibits the sustained activation of IRF3 during the later stages of an HSV-1 infection. |
complete | |||||
| GO:0019046 |
release from viral latency |
ECO:0000315 |
P |
Table 1 shows plaque formation (indicating cell lysis) before and after induction on ICP0 production. Table 10 also shows a summary of the data. |
complete | |||||
| GO:0019033 |
viral tegument |
ECO:0000314 |
C |
Figure 6C |
complete | |||||
|
part_of |
GO:0019033 |
viral tegument |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034340 |
response to type I interferon |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075342 |
disruption by symbiont of host cell PML body |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045732 |
positive regulation of protein catabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019046 |
release from viral latency |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039648 |
modulation by virus of host protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039593 |
suppression by virus of host exit from mitosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019042 |
viral latency |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060153 |
modulation by virus of host cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019046 |
release from viral latency |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Holley, MC (1985) Adaptation of a ciliary basal apparatus to cell shape changes in a contractile epithelium. Tissue Cell 17 321-34 PubMed GONUTS page
- ↑ Everett, RD et al. (2009) Analysis of the functions of herpes simplex virus type 1 regulatory protein ICP0 that are critical for lytic infection and derepression of quiescent viral genomes. J. Virol. 83 4963-77 PubMed GONUTS page
- ↑ 3.0 3.1 Henaff, D et al. (2013) Analysis of the early steps of herpes simplex virus 1 capsid tegumentation. J. Virol. 87 4895-906 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Canning, M et al. (2004) A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7. J. Biol. Chem. 279 38160-8 PubMed GONUTS page
- ↑ Negorev, DG et al. (2006) Differential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expression. J. Virol. 80 8019-29 PubMed GONUTS page
- ↑ Everett, RD et al. (2010) Comparison of the biological and biochemical activities of several members of the alphaherpesvirus ICP0 family of proteins. J. Virol. 84 3476-87 PubMed GONUTS page
- ↑ Lin, R et al. (2004) The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes. J. Virol. 78 1675-84 PubMed GONUTS page
h
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- Simplexvirus
- GO:0039648 ! symbiont-mediated perturbation of host ubiquitin-like protein modification
- GO:0039548 ! symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
- GO:0039593 ! symbiont-mediated perturbation of host exit from mitosis
- GO:0075342 ! symbiont-mediated disruption of host cell PML body
