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HELPY:O25743
Contents
| Species (Taxon ID) | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori). (85962) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Gamma-glutamyltranspeptidase (ECO:0000313 with EMBL:AFV42331.1)
Gamma-glutamyltranspeptidase (Ggt) (ECO:0000313 with EMBL:AAD08162.1) | |
| External Links | ||
| UniProt | O25743 | |
| EMBL | AE000511 CP003904 | |
| PIR | F64659 | |
| RefSeq | NP_207909.1 YP_006935034.1 | |
| PDB | 2NQO 2QM6 2QMC 3FNM | |
| PDBsum | 2NQO 2QM6 2QMC 3FNM | |
| SMR | O25743 | |
| DIP | DIP-3652N | |
| IntAct | O25743 | |
| MINT | MINT-160568 | |
| STRING | 85962.HP1118 | |
| MEROPS | T03.001 | |
| EnsemblBacteria | AAD08162 AFV42331 | |
| GeneID | 13870312 899655 | |
| KEGG | heo:C694_05770 hpy:HP1118 | |
| PATRIC | 20593579 | |
| KO | K00681 | |
| OMA | AVTNPCC | |
| OrthoDB | EOG62K1RV | |
| BioCyc | HPY:HP1118-MONOMER | |
| EvolutionaryTrace | O25743 | |
| Proteomes | UP000000429 UP000010112 | |
| GO | GO:0003840 GO:0006749 | |
| InterPro | IPR000101 IPR029055 | |
| PANTHER | PTHR11686 | |
| Pfam | PF01019 | |
| PRINTS | PR01210 | |
| SUPFAM | SSF56235 | |
| TIGRFAMs | TIGR00066 | |
| PROSITE | PS00462 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0050665 |
hydrogen peroxide biosynthetic process |
ECO:0000315 |
P |
Figure 3 shows that treatment with a GGT-containing plasmid induces production of hydrogen peroxide in AGS and gastric cells compared to no treatment or treatment with a GGT knockout |
complete | |||||
| GO:0032757 |
positive regulation of interleukin-8 production |
ECO:0000315 |
P |
Figure 5, panels A,B, and D show decreased levels of IL-8 in cells infected with GGT knockout H.pylori compared to wild type. Panel E shows decreased levels of IL-8 mRNA in cells treated with the knockout H.pylori |
complete | |||||
| GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000315 |
P |
Figure 2 panel C |
complete | |||||
| GO:1902807 |
negative regulation of cell cycle G1/S phase transition |
ECO:0000314 |
P |
Figure 2, panels A, B, and C show that when treated with rGGT, the percentage of AGS cells in the G1 phase of the cell cycle is significantly higher than the control. |
complete | |||||
|
involved_in |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902807 |
negative regulation of cell cycle G1/S phase transition |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032757 |
positive regulation of interleukin-8 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0036374 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006751 |
glutathione catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036374 |
glutathione hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Gong, M et al. (2010) Helicobacter pylori gamma-glutamyl transpeptidase is a pathogenic factor in the development of peptic ulcer disease. Gastroenterology 139 564-73 PubMed GONUTS page
- ↑ 2.0 2.1 Schmees, C et al. (2007) Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase. Gastroenterology 132 1820-33 PubMed GONUTS page
- ↑ 3.0 3.1 Kim, KM et al. (2010) Helicobacter pylori gamma-glutamyltranspeptidase induces cell cycle arrest at the G1-S phase transition. J. Microbiol. 48 372-7 PubMed GONUTS page
