PMID:17484877

Citation	Schmees, C, Prinz, C, Treptau, T, Rad, R, Hengst, L, Voland, P, Bauer, S, Brenner, L, Schmid, RM and Gerhard, M (2007) Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase. Gastroenterology 132:1820-33
Abstract	Helicobacter pylori colonizes the human gastric mucosa of >50% of the world's population. Most of the patients have no overt clinical symptoms. However, the infection is invariably associated with the development of active chronic gastritis, leading in some cases to the development of peptic ulcer disease, distal gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. In contrast to most other pathogens, infection with H pylori persists lifelong, but reasons for the persistence remain obscure. CD4-positive T cells are crucial for bacterial elimination but are inhibited by H pylori. We aimed to identify the factor responsible for suppression of T-cell response and characterize this inhibitory effect on a cellular and molecular level.
Links	PubMed Online version:10.1053/j.gastro.2007.02.031
Keywords	Apoptosis/physiology; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; G1 Phase/physiology; Gene Expression Regulation, Bacterial; Helicobacter pylori/enzymology; Humans; Interferon-gamma/secretion; Interleukin-2/secretion; Mutation/genetics; Recombinant Proteins; Signal Transduction/physiology; T-Lymphocytes/cytology; T-Lymphocytes/physiology; gamma-Glutamyltransferase/genetics; gamma-Glutamyltransferase/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HELPY:O25743	involved_in	GO:0042130: negative regulation of T cell proliferation	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
HELPY:O25743		GO:0042130: negative regulation of T cell proliferation	ECO:0000315:		P		Figure 2 panel C	complete CACAO 10437

References

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