GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:20347814
| Citation |
Gong, M, Ling, SS, Lui, SY, Yeoh, KG and Ho, B (2010) Helicobacter pylori gamma-glutamyl transpeptidase is a pathogenic factor in the development of peptic ulcer disease. Gastroenterology 139:564-73 |
|---|---|
| Abstract |
gamma-Glutamyl transpeptidase (GGT) has been reported to be a virulence factor of Helicobacter pylori associated with bacterial colonization and cell apoptosis. But its mechanism of pathogenesis is not firmly established. This study aims to examine its role in H pylori-mediated infection. |
| Links |
PubMed Online version:10.1053/j.gastro.2010.03.050 |
| Keywords |
Apoptosis; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Biopsy; Blotting, Western; Cells, Cultured; Chromatography, Gel; Chromatography, Ion Exchange; Comet Assay; DNA Damage; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorometry; Gastric Mucosa/immunology; Gastric Mucosa/microbiology; Gastric Mucosa/pathology; Helicobacter Infections/complications; Helicobacter Infections/microbiology; Helicobacter Infections/pathology; Helicobacter pylori/enzymology; Helicobacter pylori/genetics; Helicobacter pylori/pathogenicity; Humans; Hydrogen Peroxide/metabolism; Interleukin-8/genetics; Interleukin-8/metabolism; Mutation; NF-kappa B/metabolism; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; Stomach Ulcer/immunology; Stomach Ulcer/microbiology; Stomach Ulcer/pathology; Time Factors; Virulence Factors/genetics; Virulence Factors/metabolism; gamma-Glutamyltransferase/genetics; gamma-Glutamyltransferase/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0032757: positive regulation of interleukin-8 production |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0050665: hydrogen peroxide biosynthetic process |
ECO:0000315: |
P |
Figure 3 shows that treatment with a GGT-containing plasmid induces production of hydrogen peroxide in AGS and gastric cells compared to no treatment or treatment with a GGT knockout |
complete | ||||
| GO:0032757: positive regulation of interleukin-8 production |
ECO:0000315: |
P |
Figure 5, panels A,B, and D show decreased levels of IL-8 in cells infected with GGT knockout H.pylori compared to wild type. Panel E shows decreased levels of IL-8 mRNA in cells treated with the knockout H.pylori |
complete | ||||
Notes
See also
References
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