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ECOLI:MUTL

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) mutL
Protein Name(s) DNA mismatch repair protein MutL
External Links
UniProt P23367
EMBL Z11831
U14003
U00096
AP009048
M63655
L19346
PIR PH0853
RefSeq NP_418591.1
YP_492312.1
PDB 1B62
1B63
1BKN
1NHH
1NHI
1NHJ
1X9Z
PDBsum 1B62
1B63
1BKN
1NHH
1NHI
1NHJ
1X9Z
ProteinModelPortal P23367
SMR P23367
DIP DIP-10285N
IntAct P23367
MINT MINT-1266937
STRING 511145.b4170
PaxDb P23367
PRIDE P23367
EnsemblBacteria AAC77127
BAE78171
GeneID 12934482
948691
KEGG ecj:Y75_p4056
eco:b4170
PATRIC 32123913
EchoBASE EB1258
EcoGene EG11281
eggNOG COG0323
HOGENOM HOG000256551
InParanoid P23367
KO K03572
OMA FSHIDEI
OrthoDB EOG6P8TMH
PhylomeDB P23367
BioCyc EcoCyc:EG11281-MONOMER
ECOL316407:JW4128-MONOMER
MetaCyc:EG11281-MONOMER
EvolutionaryTrace P23367
PRO PR:P23367
Proteomes UP000000318
UP000000625
Genevestigator P23367
GO GO:0032300
GO:0005524
GO:0016887
GO:0003677
GO:0042802
GO:0030983
GO:0003697
GO:0006200
GO:0006298
GO:0000018
Gene3D 3.30.230.10
3.30.565.10
HAMAP MF_00149
InterPro IPR013507
IPR014762
IPR002099
IPR011186
IPR020667
IPR003594
IPR014790
IPR020568
IPR014721
PANTHER PTHR10073:SF12
Pfam PF01119
PF08676
SMART SM00387
SM00853
SUPFAM SSF54211
SSF55874
TIGRFAMs TIGR00585
PROSITE PS00058

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0032300

mismatch repair complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11281
MGI:MGI:1353455
PANTHER:PTN000008161

C

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11281
PANTHER:PTN000008161
SGD:S000004777
SGD:S000005026
UniProtKB:Q8IIJ0

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11281
MGI:MGI:101938
MGI:MGI:104288
MGI:MGI:1202302
MGI:MGI:1353455
PANTHER:PTN000008161
PomBase:SPAC19G12.02c
SGD:S000004025
SGD:S000004777
SGD:S000005026
SGD:S000006085
TAIR:locus:2133274
UniProtKB:P40692
UniProtKB:P54278

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:19376855[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P23367

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:11585365[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P23367

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:24561554[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P23367

F

Seeded From UniProt

complete

part_of

GO:0032300

mismatch repair complex

PMID:6987663[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P06722
UniProtKB:P23909

C

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

PMID:9827806[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

PMID:9827806[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:6987663[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:2665076[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:9827806[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:12606120[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:12606120[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000018

regulation of DNA recombination

PMID:2555716[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002099
InterPro:IPR013507
InterPro:IPR014790

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002099
InterPro:IPR013507
InterPro:IPR014790
InterPro:IPR020667
InterPro:IPR038973

P

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038973

F

Seeded From UniProt

complete

enables

GO:0030983

mismatched DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002099
InterPro:IPR013507

F

Seeded From UniProt

complete

part_of

GO:0032300

mismatch repair complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038973

C

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000001258

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Polosina, YY et al. (2009) The Escherichia coli mismatch repair protein MutL recruits the Vsr and MutH endonucleases in response to DNA damage. J. Bacteriol. 191 4041-3 PubMed GONUTS page
  3. ↑ Mansour, CA et al. (2001) Characterization of functional interactions among the Escherichia coli mismatch repair proteins using a bacterial two-hybrid assay. Mutat. Res. 485 331-8 PubMed GONUTS page
  4. ↑ Rajagopala, SV et al. (2014) The binary protein-protein interaction landscape of Escherichia coli. Nat. Biotechnol. 32 285-90 PubMed GONUTS page
  5. ↑ 5.0 5.1 Glickman, BW & Radman, M (1980) Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction. Proc. Natl. Acad. Sci. U.S.A. 77 1063-7 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Ban, C & Yang, W (1998) Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. Cell 95 541-52 PubMed GONUTS page
  7. ↑ Lahue, RS et al. (1989) DNA mismatch correction in a defined system. Science 245 160-4 PubMed GONUTS page
  8. ↑ 8.0 8.1 Junop, MS et al. (2003) In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination. DNA Repair (Amst.) 2 387-405 PubMed GONUTS page
  9. ↑ Rayssiguier, C et al. (1989) The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature 342 396-401 PubMed GONUTS page
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