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PMID:2555716

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Citation

Rayssiguier, C, Thaler, DS and Radman, M (1989) The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature 342:396-401

Abstract

The requirement for DNA sequence homology in generalized genetic recombination is greatly relaxed in bacterial mutL, mutS and mutH mutants deficient in mismatch repair. In such mutants, intergeneric recombination occurs efficiently between Escherichia coli and Salmonella typhimurium, which are approximately 20% divergent in DNA sequence. This finding has implications for speciation, for regulating recombination between diverged repeated sequences, and for hitherto difficult interspecies hybridizations.

Links

PubMed Online version:10.1038/342396a0

Keywords

Alleles; Conjugation, Genetic; Crosses, Genetic; DNA Repair; DNA Transposable Elements; Escherichia coli/genetics; Genotype; Mutation; Recombination, Genetic; Restriction Mapping; Salmonella typhimurium/genetics; Transduction, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ECOLI:MUTH

acts_upstream_of_or_within

GO:0000018: regulation of DNA recombination

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:MUTL

acts_upstream_of_or_within

GO:0000018: regulation of DNA recombination

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:MUTS

acts_upstream_of_or_within

GO:0000018: regulation of DNA recombination

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:MUTL

involved_in

GO:0000018: regulation of DNA recombination

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:MUTS

involved_in

GO:0000018: regulation of DNA recombination

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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