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EBOZM:VGP
Contents
| Species (Taxon ID) | Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus). (128952) | |
| Gene Name(s) | GP | |
| Protein Name(s) | Envelope glycoprotein
GP1,2 GP GP1 GP2 GP2-delta | |
| External Links | ||
| UniProt | Q05320 | |
| EMBL | L11365 U31033 U23187 AF272001 AY142960 AF086833 AF499101 | |
| PIR | S23155 | |
| RefSeq | NP_066246.1 | |
| PDB | 2EBO 2RLJ 3CSY | |
| PDBsum | 2EBO 2RLJ 3CSY | |
| ProteinModelPortal | Q05320 | |
| SMR | Q05320 | |
| TCDB | 1.G.12.2.2 | |
| GeneID | 911829 | |
| EvolutionaryTrace | Q05320 | |
| Proteomes | UP000007209 | |
| GO | GO:0005737 GO:0044165 GO:0020002 GO:0016021 GO:0045121 GO:0019031 GO:0055036 GO:0075512 GO:0039654 GO:0039587 GO:0039502 GO:0046761 GO:0046718 GO:0019062 | |
| InterPro | IPR014625 IPR002561 | |
| Pfam | PF01611 | |
| PIRSF | PIRSF036874 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0030430 |
host cell cytoplasm |
ECO:0000314 |
C |
Fig. 2 |
complete | |||||
| GO:0046718 |
entry of virus into host cell |
ECO:0000315 |
P |
Fig. 5C |
complete | |||||
| GO:0044165 |
host cell endoplasmic reticulum |
ECO:0000315 |
C |
Fig. 1B |
complete | |||||
| GO:0045121 |
membrane raft |
ECO:0000314 |
C |
Figure 1: This Western blot for GP demonstrates the localization of GP in the lipid rafts. |
complete | |||||
| GO:0046761 |
viral budding from plasma membrane |
ECO:0000314 |
P |
Figure 6B: Immunogold staining of the virus like particles with anti-Ebola GP antibodies demonstrated the identity of the spikes on the surface of the particles as Ebola GP. |
complete | |||||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046761 |
viral budding from plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044165 |
host cell endoplasmic reticulum |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039663 |
membrane fusion involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039654 |
fusion of virus membrane with host endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0098670 |
entry receptor-mediated virion attachment to host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019062 |
virion attachment to host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075512 |
clathrin-dependent endocytosis of virus by host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039587 |
suppression by virus of host tetherin activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019031 |
viral envelope |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075509 |
endocytosis involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0055036 |
virion membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Bhattacharyya, S et al. (2010) Ebola virus uses clathrin-mediated endocytosis as an entry pathway. Virology 401 18-28 PubMed GONUTS page
- ↑ 2.0 2.1 Bhattacharyya, S & Hope, TJ (2011) Full-length Ebola glycoprotein accumulates in the endoplasmic reticulum. Virol. J. 8 11 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Bavari, S et al. (2002) Lipid raft microdomains: a gateway for compartmentalized trafficking of Ebola and Marburg viruses. J. Exp. Med. 195 593-602 PubMed GONUTS page
- ↑ Misasi, J et al. (2016) Structural and molecular basis for Ebola virus neutralization by protective human antibodies. Science 351 1343-6 PubMed GONUTS page
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