DROME:TRPA1

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	TrpA1 (synonyms: Anktm1)
Protein Name(s)	Transient receptor potential cation channel subfamily A member 1 dTRPA1 Ankyrin-like with transmembrane domains protein 1 dANKTM1
External Links
UniProt	Q7Z020
EMBL	AY302598 AE014296 AE014296
RefSeq	NP_001097554.4 NP_648263.5
UniGene	Dm.15461
IntAct	Q7Z020
STRING	7227.FBpp0289445
TCDB	1.A.4.6.2
PaxDb	Q7Z020
GeneID	39015
KEGG	dme:Dmel_CG5751
CTD	8989
FlyBase	FBgn0035934
eggNOG	COG0666
InParanoid	Q7Z020
KO	K04984
OrthoDB	EOG7P02H2
Reactome	REACT_184319
SignaLink	Q7Z020
GenomeRNAi	39015
NextBio	811470
PRO	PR:Q7Z020
Proteomes	UP000000803
Bgee	Q7Z020
ExpressionAtlas	Q7Z020
GO	GO:0034703 GO:0016021 GO:0005261 GO:0015276 GO:0006816 GO:0098655 GO:0006812 GO:0034605 GO:0001580 GO:0050968 GO:0050965 GO:0050960 GO:0034220 GO:0007638 GO:0046957 GO:0007602 GO:0009408 GO:0010378 GO:0040040 GO:0043052
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR005821 IPR030288
PANTHER	PTHR24171:SF3
Pfam	PF00023 PF12796 PF00520
PRINTS	PR01415
SMART	SM00248
SUPFAM	SSF48403
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0043052	thermotaxis	PMID:22139422^[1]	ECO:0000315			P	Figure 3 references differing sensitivity to warmth in TrpA1 mutants	complete CACAO 5192
part_of	GO:0016021	integral component of membrane	PMID:12815418^[2]	ECO:0000305	curator inference used in manual assertion	GO:0005261	C	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	PMID:12815418^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006812	cation transport	PMID:12815418^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	PMID:12815418^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046957	negative phototaxis	PMID:24009394^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010378	temperature compensation of the circadian clock	PMID:23595730^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:23027824^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0097604	temperature-gated cation channel activity	PMID:23027824^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006812	cation transport	PMID:23027824^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	PMID:23027824^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0050960	detection of temperature stimulus involved in thermoception	PMID:23027824^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007638	mechanosensory behavior	PMID:22347718^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0040040	thermosensory behavior	PMID:22347718^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	PMID:21909389^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050960	detection of temperature stimulus involved in thermoception	PMID:21909389^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043052	thermotaxis	PMID:21393546^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009416	response to light stimulus	PMID:21068723^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046957	negative phototaxis	PMID:21068723^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	PMID:21068723^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0023041	neuronal signal transduction	PMID:21068723^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	PMID:20404155^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|enables	GO:0033038	bitter taste receptor activity	PMID:20404155^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015276	ligand-gated ion channel activity	PMID:20237474^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	PMID:20237474^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043052	thermotaxis	PMID:18660806^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050850	positive regulation of calcium-mediated signaling	PMID:18548007^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:18548007^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0097604	temperature-gated cation channel activity	PMID:18548007^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:18548007^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:18548007^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050960	detection of temperature stimulus involved in thermoception	PMID:18548007^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043052	thermotaxis	PMID:15681611^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0097604	temperature-gated cation channel activity	PMID:12815418^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:12815418^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:10798390^[15]	ECO:0000250	sequence similarity evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
enables	GO:0097604	temperature-gated cation channel activity	PMID:27749829^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	PMID:27749829^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005262	P	Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005261	P	Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097604	P	Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097604	P	Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097604	P	Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097604	P	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR030288	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030288	C	Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030288	P	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kang, K et al. (2012) Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila. Nature 481 76-80 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Viswanath, V et al. (2003) Opposite thermosensor in fruitfly and mouse. Nature 423 822-3 PubMed GONUTS page
↑ Yamanaka, N et al. (2013) Neuroendocrine control of Drosophila larval light preference. Science 341 1113-6 PubMed GONUTS page
↑ Lee, Y & Montell, C (2013) Drosophila TRPA1 functions in temperature control of circadian rhythm in pacemaker neurons. J. Neurosci. 33 6716-25 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Wang, H et al. (2013) Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli. J. Physiol. (Lond.) 591 185-201 PubMed GONUTS page
↑ ^6.0 ^6.1 Zhong, L et al. (2012) Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. Cell Rep 1 43-55 PubMed GONUTS page
↑ ^7.0 ^7.1 Neely, GG et al. (2011) TrpA1 regulates thermal nociception in Drosophila. PLoS ONE 6 e24343 PubMed GONUTS page
↑ Shen, WL et al. (2011) Function of rhodopsin in temperature discrimination in Drosophila. Science 331 1333-6 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Xiang, Y et al. (2010) Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature 468 921-6 PubMed GONUTS page
↑ ^10.0 ^10.1 Kim, SH et al. (2010) Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons. Proc. Natl. Acad. Sci. U.S.A. 107 8440-5 PubMed GONUTS page
↑ ^11.0 ^11.1 Kang, K et al. (2010) Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception. Nature 464 597-600 PubMed GONUTS page
↑ Kwon, Y et al. (2008) Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat. Neurosci. 11 871-3 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Hamada, FN et al. (2008) An internal thermal sensor controlling temperature preference in Drosophila. Nature 454 217-20 PubMed GONUTS page
↑ Rosenzweig, M et al. (2005) The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev. 19 419-24 PubMed GONUTS page
↑ Littleton, JT & Ganetzky, B (2000) Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron 26 35-43 PubMed GONUTS page
↑ ^16.0 ^16.1 Luo, J et al. (2017) TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae. Nat. Neurosci. 20 34-41 PubMed GONUTS page

[PMID:22139422-1] Kang, K et al. (2012) Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila. Nature 481 76-80 PubMed GONUTS page

[PMID:12815418-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Viswanath, V et al. (2003) Opposite thermosensor in fruitfly and mouse. Nature 423 822-3 PubMed GONUTS page

[PMID:24009394-3] Yamanaka, N et al. (2013) Neuroendocrine control of Drosophila larval light preference. Science 341 1113-6 PubMed GONUTS page

[PMID:23595730-4] Lee, Y & Montell, C (2013) Drosophila TRPA1 functions in temperature control of circadian rhythm in pacemaker neurons. J. Neurosci. 33 6716-25 PubMed GONUTS page

[PMID:23027824-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Wang, H et al. (2013) Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli. J. Physiol. (Lond.) 591 185-201 PubMed GONUTS page

[PMID:22347718-6] 6.0 ^6.1 Zhong, L et al. (2012) Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. Cell Rep 1 43-55 PubMed GONUTS page

[PMID:21909389-7] 7.0 ^7.1 Neely, GG et al. (2011) TrpA1 regulates thermal nociception in Drosophila. PLoS ONE 6 e24343 PubMed GONUTS page

[PMID:21393546-8] Shen, WL et al. (2011) Function of rhodopsin in temperature discrimination in Drosophila. Science 331 1333-6 PubMed GONUTS page

[PMID:21068723-9] 9.0 ^9.1 ^9.2 ^9.3 Xiang, Y et al. (2010) Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature 468 921-6 PubMed GONUTS page

[PMID:20404155-10] 10.0 ^10.1 Kim, SH et al. (2010) Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons. Proc. Natl. Acad. Sci. U.S.A. 107 8440-5 PubMed GONUTS page

[PMID:20237474-11] 11.0 ^11.1 Kang, K et al. (2010) Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception. Nature 464 597-600 PubMed GONUTS page

[PMID:18660806-12] Kwon, Y et al. (2008) Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat. Neurosci. 11 871-3 PubMed GONUTS page

[PMID:18548007-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Hamada, FN et al. (2008) An internal thermal sensor controlling temperature preference in Drosophila. Nature 454 217-20 PubMed GONUTS page

[PMID:15681611-14] Rosenzweig, M et al. (2005) The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev. 19 419-24 PubMed GONUTS page

[PMID:10798390-15] Littleton, JT & Ganetzky, B (2000) Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron 26 35-43 PubMed GONUTS page

[PMID:27749829-16] 16.0 ^16.1 Luo, J et al. (2017) TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae. Nat. Neurosci. 20 34-41 PubMed GONUTS page

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DROME:TRPA1

Contents

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