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PMID:21393546

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Citation

Shen, WL, Kwon, Y, Adegbola, AA, Luo, J, Chess, A and Montell, C (2011) Function of rhodopsin in temperature discrimination in Drosophila. Science 331:1333-6

Abstract

Many animals, including the fruit fly, are sensitive to small differences in ambient temperature. The ability of Drosophila larvae to choose their ideal temperature (18°C) over other comfortable temperatures (19° to 24°C) depends on a thermosensory signaling pathway that includes a heterotrimeric guanine nucleotide-binding protein (G protein), a phospholipase C, and the transient receptor potential TRPA1 channel. We report that mutation of the gene (ninaE) encoding a classical G protein-coupled receptor (GPCR), Drosophila rhodopsin, eliminates thermotactic discrimination in the comfortable temperature range. This role for rhodopsin in thermotaxis toward 18°C was light-independent. Introduction of mouse melanopsin restored normal thermotactic behavior in ninaE mutant larvae. We propose that rhodopsins represent a class of evolutionarily conserved GPCRs that are required for initiating thermosensory signaling cascades.

Links

PubMed Online version:10.1126/science.1198904

Keywords

Animals; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Eye Proteins/genetics; Eye Proteins/physiology; Larva/genetics; Larva/physiology; Light; Mice; Movement; Mutation; Photoreceptor Cells, Invertebrate/physiology; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/physiology; Rhodopsin/genetics; Rhodopsin/physiology; Rod Opsins/genetics; Rod Opsins/physiology; Signal Transduction; TRPC Cation Channels/genetics; TRPC Cation Channels/metabolism; Temperature; Thermosensing

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:OPS1

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:PIPA

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:GNAQ

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q961H6

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VM10

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:TRPA1

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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