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PMID:15681611
| Citation |
Rosenzweig, M, Brennan, KM, Tayler, TD, Phelps, PO, Patapoutian, A and Garrity, PA (2005) The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev. 19:419-24 |
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| Abstract |
Thermotaxis is important for animal survival, but the molecular identities of temperature sensors controlling this behavior have not been determined. We demonstrate dTRPA1, a heat-activated Transient Receptor Potential (TRP) family ion channel, is essential for thermotaxis in Drosophila. dTrpA1 knockdown eliminates avoidance of elevated temperatures along a thermal gradient. We observe dTRPA1 expression in cells without previously ascribed roles in thermosensation and implicate dTRPA1-expressing neurons in mediating thermotaxis. Our data suggest that thermotaxis relies upon neurons and molecules distinct from those required for high-temperature nociception. We propose dTRPA1 may control thermotaxis by sensing environmental temperature. |
| Links |
PubMed PMC548941 Online version:10.1101/gad.1278205 |
| Keywords |
Animals; Body Temperature Regulation/physiology; Drosophila/growth & development; Drosophila/physiology; Drosophila Proteins/physiology; Hot Temperature; Ion Channels/physiology; Larva/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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