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PMID:18660806

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Citation

Kwon, Y, Shim, HS, Wang, X and Montell, C (2008) Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat. Neurosci. 11:871-3

Abstract

In animals such as the fruitfly, even minor deviations in environmental temperature can have major impacts on development and lifespan. Here we demonstrated that the ability of Drosophila melanogaster larvae to discriminate between the optimal temperature of 18 degrees C and slightly higher temperatures (19-24 degrees C) depended on the TRPA1 channel, which functioned downstream of a phospholipase C-dependent signaling cascade similar to that used in fly phototransduction. We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range.

Links

PubMed Online version:10.1038/nn.2170

Keywords

Adaptation, Physiological/genetics; Adaptation, Physiological/physiology; Animals; Animals, Genetically Modified; Behavior, Animal; Choice Behavior/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Larva/genetics; Larva/physiology; Motor Activity/genetics; Motor Activity/physiology; Mutagenesis; Signal Transduction/genetics; Signal Transduction/physiology; TRPC Cation Channels/genetics; TRPC Cation Channels/metabolism; Temperature; Type C Phospholipases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:GNAQ

involved_in

GO:0043052: thermotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:RDGC

involved_in

GO:0043052: thermotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CDS

involved_in

GO:0043052: thermotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DGK2

involved_in

GO:0043052: thermotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VNU2

involved_in

GO:0043052: thermotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:TRPA1

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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