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DROME:SYMM

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Aats-met
Protein Name(s) Methionine--tRNA ligase, mitochondrial

Mitochondrial methionyl-tRNA synthetase MtMetRS

External Links
UniProt Q9VFL5
EMBL AE014297
AY069128
RefSeq NP_001262564.1
NP_650348.1
UniGene Dm.1570
ProteinModelPortal Q9VFL5
SMR Q9VFL5
BioGrid 66809
IntAct Q9VFL5
MINT MINT-1023892
PaxDb Q9VFL5
EnsemblMetazoa FBtr0082895
GeneID 41733
KEGG dme:Dmel_CG31322
CTD 41733
FlyBase FBgn0027083
eggNOG COG0143
GeneTree ENSGT00550000075136
InParanoid Q9VFL5
KO K01874
OMA TCFPSEP
OrthoDB EOG76MK87
PhylomeDB Q9VFL5
GenomeRNAi 41733
NextBio 825286
PRO PR:Q9VFL5
Proteomes UP000000803
Bgee Q9VFL5
GO GO:0005759
GO:0005524
GO:0004825
GO:0006431
Gene3D 1.10.730.10
3.40.50.620
InterPro IPR014758
IPR015413
IPR014729
IPR009080
Pfam PF09334
PRINTS PR01041
SUPFAM SSF47323
TIGRFAMs TIGR00398

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045494

photoreceptor cell maintenance

PMID:22448145[1]

ECO:0000315

P

Figure 2: Loss of Aats-met in the Eye Results in Retinal Degeneration

complete
CACAO 5883

GO:0008340

determination of adult lifespan

PMID:22448145[1]

ECO:0000315

P

Figure 2J, 3A, 3C: Loss of Aats-met Results in Reduced Lifespan

complete
CACAO 5884

GO:0044429

mitochondrial part

PMID:22448145[1]

ECO:0000315

C

Figure 3C-E: Mitochondria are clearly aberrant; they are larger than normal

complete
CACAO 5885

GO:0007629

flight behavior

PMID:22448145[1]

ECO:0000315

P

Figure 2: mutants missing Aats-mets are unable to fly.

complete
CACAO 5890

involved_in

GO:0006431

methionyl-tRNA aminoacylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96GW9

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96GW9

C

Seeded From UniProt

complete

enables

GO:0004825

methionine-tRNA ligase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96GW9

F

Seeded From UniProt

complete

involved_in

GO:0006431

methionyl-tRNA aminoacylation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000235847
SGD:S000003403
UniProtKB:Q8IJ60
UniProtKB:Q96GW9

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000942566
SGD:S000003403

C

Seeded From UniProt

complete

enables

GO:0004825

methionine-tRNA ligase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000235847
SGD:S000003403
UniProtKB:A0A1D8PP08
UniProtKB:P9WFU5
UniProtKB:Q8IJ60
UniProtKB:Q96GW9
UniProtKB:Q9M2T9

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009080
InterPro:IPR014758
InterPro:IPR015413

F

Seeded From UniProt

complete

enables

GO:0004812

aminoacyl-tRNA ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009080
InterPro:IPR015413

F

Seeded From UniProt

complete

enables

GO:0004825

methionine-tRNA ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014758
InterPro:IPR033911

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009080
InterPro:IPR014758
InterPro:IPR015413

F

Seeded From UniProt

complete

involved_in

GO:0006418

tRNA aminoacylation for protein translation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009080
InterPro:IPR015413

P

Seeded From UniProt

complete

involved_in

GO:0006431

methionyl-tRNA aminoacylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014758
InterPro:IPR033911

P

Seeded From UniProt

complete

enables

GO:0004825

methionine-tRNA ligase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.1.1.10

F

Seeded From UniProt

complete

enables

GO:0004825

methionine-tRNA ligase activity

PMID:26761199[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006431

methionyl-tRNA aminoacylation

PMID:26761199[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:26761199[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

involved_in

GO:0006412

translation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0648

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

enables

GO:0004812

aminoacyl-tRNA ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0030

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Bayat, V et al. (2012) Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol. 10 e1001288 PubMed GONUTS page
  2. 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 Lu, J et al. (2015) The aminoacyl-tRNA synthetases of Drosophila melanogaster. Fly (Austin) 9 53-61 PubMed GONUTS page