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DROME:SYMM
Contents
Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
Gene Name(s) | Aats-met | |
Protein Name(s) | Methionine--tRNA ligase, mitochondrial
Mitochondrial methionyl-tRNA synthetase MtMetRS | |
External Links | ||
UniProt | Q9VFL5 | |
EMBL | AE014297 AY069128 | |
RefSeq | NP_001262564.1 NP_650348.1 | |
UniGene | Dm.1570 | |
ProteinModelPortal | Q9VFL5 | |
SMR | Q9VFL5 | |
BioGrid | 66809 | |
IntAct | Q9VFL5 | |
MINT | MINT-1023892 | |
PaxDb | Q9VFL5 | |
EnsemblMetazoa | FBtr0082895 | |
GeneID | 41733 | |
KEGG | dme:Dmel_CG31322 | |
CTD | 41733 | |
FlyBase | FBgn0027083 | |
eggNOG | COG0143 | |
GeneTree | ENSGT00550000075136 | |
InParanoid | Q9VFL5 | |
KO | K01874 | |
OMA | TCFPSEP | |
OrthoDB | EOG76MK87 | |
PhylomeDB | Q9VFL5 | |
GenomeRNAi | 41733 | |
NextBio | 825286 | |
PRO | PR:Q9VFL5 | |
Proteomes | UP000000803 | |
Bgee | Q9VFL5 | |
GO | GO:0005759 GO:0005524 GO:0004825 GO:0006431 | |
Gene3D | 1.10.730.10 3.40.50.620 | |
InterPro | IPR014758 IPR015413 IPR014729 IPR009080 | |
Pfam | PF09334 | |
PRINTS | PR01041 | |
SUPFAM | SSF47323 | |
TIGRFAMs | TIGR00398 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0045494 |
photoreceptor cell maintenance |
ECO:0000315 |
P |
Figure 2: Loss of Aats-met in the Eye Results in Retinal Degeneration |
complete | |||||
GO:0008340 |
determination of adult lifespan |
ECO:0000315 |
P |
Figure 2J, 3A, 3C: Loss of Aats-met Results in Reduced Lifespan |
complete | |||||
GO:0044429 |
mitochondrial part |
ECO:0000315 |
C |
Figure 3C-E: Mitochondria are clearly aberrant; they are larger than normal |
complete | |||||
GO:0007629 |
flight behavior |
ECO:0000315 |
P |
Figure 2: mutants missing Aats-mets are unable to fly. |
complete | |||||
involved_in |
GO:0006431 |
methionyl-tRNA aminoacylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004825 |
methionine-tRNA ligase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006431 |
methionyl-tRNA aminoacylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000235847 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000942566 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004825 |
methionine-tRNA ligase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000235847 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004812 |
aminoacyl-tRNA ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004825 |
methionine-tRNA ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006418 |
tRNA aminoacylation for protein translation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006431 |
methionyl-tRNA aminoacylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004825 |
methionine-tRNA ligase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004825 |
methionine-tRNA ligase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006431 |
methionyl-tRNA aminoacylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006412 |
translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004812 |
aminoacyl-tRNA ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Bayat, V et al. (2012) Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol. 10 e1001288 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Lu, J et al. (2015) The aminoacyl-tRNA synthetases of Drosophila melanogaster. Fly (Austin) 9 53-61 PubMed GONUTS page