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DROME:SYMM

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Aats-met
Protein Name(s) Methionine--tRNA ligase, mitochondrial

Mitochondrial methionyl-tRNA synthetase MtMetRS

External Links
UniProt Q9VFL5
EMBL AE014297
AY069128
RefSeq NP_001262564.1
NP_650348.1
UniGene Dm.1570
ProteinModelPortal Q9VFL5
SMR Q9VFL5
BioGrid 66809
IntAct Q9VFL5
MINT MINT-1023892
PaxDb Q9VFL5
EnsemblMetazoa FBtr0082895
GeneID 41733
KEGG dme:Dmel_CG31322
CTD 41733
FlyBase FBgn0027083
eggNOG COG0143
GeneTree ENSGT00550000075136
InParanoid Q9VFL5
KO K01874
OMA TCFPSEP
OrthoDB EOG76MK87
PhylomeDB Q9VFL5
GenomeRNAi 41733
NextBio 825286
PRO PR:Q9VFL5
Proteomes UP000000803
Bgee Q9VFL5
GO GO:0005759
GO:0005524
GO:0004825
GO:0006431
Gene3D 1.10.730.10
3.40.50.620
InterPro IPR014758
IPR015413
IPR014729
IPR009080
Pfam PF09334
PRINTS PR01041
SUPFAM SSF47323
TIGRFAMs TIGR00398

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0045494

photoreceptor cell maintenance

PMID:22448145[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2: Loss of Aats-met in the Eye Results in Retinal Degeneration

complete
CACAO 5883

GO:0008340

determination of adult lifespan

PMID:22448145[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2J, 3A, 3C: Loss of Aats-met Results in Reduced Lifespan

complete
CACAO 5884

GO:0044429

mitochondrial part

PMID:22448145[1]

IMP: Inferred from Mutant Phenotype

C

Figure 3C-E: Mitochondria are clearly aberrant; they are larger than normal

complete
CACAO 5885

GO:0007629

flight behavior

PMID:22448145[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2: mutants missing Aats-mets are unable to fly.

complete
CACAO 5890

GO:0000166

nucleotide binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009080
InterPro:IPR014758
InterPro:IPR015413

F

Seeded From UniProt

complete

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0004812

aminoacyl-tRNA ligase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009080
InterPro:IPR015413

F

Seeded From UniProt

complete

GO:0004812

aminoacyl-tRNA ligase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0030

F

Seeded From UniProt

complete

GO:0004825

methionine-tRNA ligase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014758

F

Seeded From UniProt

complete

GO:0004825

methionine-tRNA ligase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:6.1.1.10

F

Seeded From UniProt

complete

GO:0004825

methionine-tRNA ligase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q96GW9

F

Seeded From UniProt

complete

GO:0004825

methionine-tRNA ligase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000235847

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009080
InterPro:IPR014758
InterPro:IPR015413

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014758

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

GO:0005759

mitochondrial matrix

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q96GW9

C

Seeded From UniProt

complete

GO:0005759

mitochondrial matrix

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

GO:0006412

translation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0648

P

Seeded From UniProt

complete

GO:0006418

tRNA aminoacylation for protein translation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009080
InterPro:IPR015413

P

Seeded From UniProt

complete

GO:0006431

methionyl-tRNA aminoacylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014758

P

Seeded From UniProt

complete

GO:0006431

methionyl-tRNA aminoacylation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q96GW9

P

Seeded From UniProt

complete

GO:0006431

methionyl-tRNA aminoacylation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000235847

P

Seeded From UniProt

complete

GO:0016874

ligase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

NOT

GO:0005829

cytosol

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000942566

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Bayat, V et al. (2012) Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol. 10 e1001288 PubMed GONUTS page