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DROME:SYMM
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | Aats-met | |
| Protein Name(s) | Methionine--tRNA ligase, mitochondrial
Mitochondrial methionyl-tRNA synthetase MtMetRS | |
| External Links | ||
| UniProt | Q9VFL5 | |
| EMBL | AE014297 AY069128 | |
| RefSeq | NP_001262564.1 NP_650348.1 | |
| UniGene | Dm.1570 | |
| ProteinModelPortal | Q9VFL5 | |
| SMR | Q9VFL5 | |
| BioGrid | 66809 | |
| IntAct | Q9VFL5 | |
| MINT | MINT-1023892 | |
| PaxDb | Q9VFL5 | |
| EnsemblMetazoa | FBtr0082895 | |
| GeneID | 41733 | |
| KEGG | dme:Dmel_CG31322 | |
| CTD | 41733 | |
| FlyBase | FBgn0027083 | |
| eggNOG | COG0143 | |
| GeneTree | ENSGT00550000075136 | |
| InParanoid | Q9VFL5 | |
| KO | K01874 | |
| OMA | TCFPSEP | |
| OrthoDB | EOG76MK87 | |
| PhylomeDB | Q9VFL5 | |
| GenomeRNAi | 41733 | |
| NextBio | 825286 | |
| PRO | PR:Q9VFL5 | |
| Proteomes | UP000000803 | |
| Bgee | Q9VFL5 | |
| GO | GO:0005759 GO:0005524 GO:0004825 GO:0006431 | |
| Gene3D | 1.10.730.10 3.40.50.620 | |
| InterPro | IPR014758 IPR015413 IPR014729 IPR009080 | |
| Pfam | PF09334 | |
| PRINTS | PR01041 | |
| SUPFAM | SSF47323 | |
| TIGRFAMs | TIGR00398 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045494 |
photoreceptor cell maintenance |
ECO:0000315 |
P |
Figure 2: Loss of Aats-met in the Eye Results in Retinal Degeneration |
complete | |||||
| GO:0008340 |
determination of adult lifespan |
ECO:0000315 |
P |
Figure 2J, 3A, 3C: Loss of Aats-met Results in Reduced Lifespan |
complete | |||||
| GO:0044429 |
mitochondrial part |
ECO:0000315 |
C |
Figure 3C-E: Mitochondria are clearly aberrant; they are larger than normal |
complete | |||||
| GO:0007629 |
flight behavior |
ECO:0000315 |
P |
Figure 2: mutants missing Aats-mets are unable to fly. |
complete | |||||
|
involved_in |
GO:0006431 |
methionyl-tRNA aminoacylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004825 |
methionine-tRNA ligase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006431 |
methionyl-tRNA aminoacylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000235847 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000942566 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004825 |
methionine-tRNA ligase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000235847 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004812 |
aminoacyl-tRNA ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004825 |
methionine-tRNA ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006418 |
tRNA aminoacylation for protein translation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006431 |
methionyl-tRNA aminoacylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004825 |
methionine-tRNA ligase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004825 |
methionine-tRNA ligase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006431 |
methionyl-tRNA aminoacylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006412 |
translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004812 |
aminoacyl-tRNA ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Bayat, V et al. (2012) Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol. 10 e1001288 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Lu, J et al. (2015) The aminoacyl-tRNA synthetases of Drosophila melanogaster. Fly (Austin) 9 53-61 PubMed GONUTS page
